A5048106257- Chemical Reactions and Isotopes
- Phagocytosis and Immune Regulation
- Hearing Loss and Rehabilitation
- Lung Cancer Treatments and Mutations
- Cancer Mechanisms and Therapy
- Glioma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Genetic and Kidney Cyst Diseases
- Cancer, Hypoxia, and Metabolism
- Hearing, Cochlea, Tinnitus, Genetics
- Noise Effects and Management
- Anesthesia and Pain Management
- Mobile Learning in Education
- Indian and Buddhist Studies
- Brain Metastases and Treatment
- Spine and Intervertebral Disc Pathology
- Pain Mechanisms and Treatments
- Digital literacy in education
- Hearing Impairment and Communication
- Liver physiology and pathology
- Cultural Heritage Management and Preservation
- Shoulder Injury and Treatment
Gifu University
2010-2024
University of Alabama at Birmingham
2017-2024
Osaka Health Science University
2019-2023
Kyoto University
1999-2023
United Nations University Institute on Globalization, Culture and Mobility
2023
Toyo University
2016-2022
Kansai University of Welfare Sciences
2021
Ehime University
2020
Tokyo Institute of Technology
2010-2019
Gifu University Hospital
2006-2019
Type 2 diabetes mellitus (T2DM) is associated with a high incidence of non-alcoholic fatty liver disease (NAFLD) related to obesity and insulin resistance. Currently, medical interventions for NAFLD have focused on diet control exercise reduce body weight, there requirement effective pharmacological therapies. Sodium-glucose cotransporter (SGLT2) inhibitors are oral antidiabetic drugs that promote the urinary excretion glucose by blocking its reabsorption in renal proximal tubules. SGLT2...
Interleukin (IL)-6 plays a pivotal role in variety of CNS functions such as the induction and modulation reactive astrogliosis, pathological inflammatory responses neuroprotection. Tumor necrosis factor (TNF)-α induces IL-6 release from rat C6 glioma cells through inhibitory kappa B (IκB)-nuclear (NFκB) pathway, p38 mitogen-activated protein (MAP) kinase stress-activated (SAPK)/c-Jun N-terminal (JNK). The present study investigated mechanism TNF-α-induced more detail than has previously been...
Sodium glucose cotransporter 2 (SGLT2) inhibitors, an antidiabetic drug, promotes urinary excretion of by blocking its reabsorption in the renal proximal tubules. It is unclear whether SGLT2 inhibition could attenuate nonalcoholic steatohepatitis (NASH) and NASH-associated hepatocellular carcinoma. We examined preventive effects inhibitor canagliflozin (CANA) Western diet (WD)-fed melanocortin 4 receptor-deficient (MC4R-KO) mice, a mouse model human NASH. An eight-week CANA treatment...
Abstract Glioblastoma (GBM) is a lethal disease with no effective therapies available. We previously observed upregulation of the TAM (Tyro-3, Axl, and Mer) receptor tyrosine kinase family member AXL in mesenchymal GBM showed that knockdown induced apoptosis mesenchymal, but not proneural, glioma sphere cultures (GSC). In this study, we report BGB324, novel small molecule inhibitor AXL, prolongs survival immunocompromised mice bearing GSC-derived GBM-like tumors. show protein S (PROS1),...
Abstract Intratumor spatial heterogeneity facilitates therapeutic resistance in glioblastoma (GBM). Nonetheless, understanding of GBM is largely limited to the surgically resectable tumor core lesion while seeds for recurrence reside unresectable edge. In this study, stratification and edge demonstrates clinically relevant surgical sequelae. We establish regionally derived models that retain their identity a cell autonomous manner. Upon xenotransplantation, edge-derived cells show higher...
This paper examines the influences of professional development activities on important teacher-level factors that are for use Information and Communication Technology (ICT) in education primary school teachers Mongolia. The study utilizes survey data collected 2012 (n = 826) 2016 1161) to identify changes ICT education. result shows six teacher level integration have been improved over time through activities. These competency educational ICT, collaboration integration, benefits autonomy...
This study is motivated by the initiative to implement mobile learning promote world heritage site awareness among young adults living in town of Luang Prabang Lao People’s Democratic Republic (PDR). Mobile still its infant stage Laos. The objective this investigate drivers acceptance Prabang. Structural equation modeling analysis based on 349 students higher education indicates that perceived usefulness, ease use, and enjoyment directly affected their behavioral intention use learning....
Although dysregulated cholesterol metabolism predisposes aging tissues to inflammation and a plethora of diseases, the underlying molecular mechanism remains poorly defined. Here, we show that metabolic genotoxic stresses, convergently acting through liver X nuclear receptor, upregulate CD38 promote lysosomal efflux, leading nicotinamide adenine dinucleotide (NAD
Obesity promotes infiltration of inflammatory cells into various tissues, leading to parenchymal and stromal cell interaction development cellular organ dysfunction. Liver sinusoidal endothelial (LSECs) are the first that contact portal blood substances in liver, but their functions obesity-associated glucose metabolism remain unclear. Here, we find LSECs involved accumulation myeloid via VLA-4-dependent cell-cell adhesion. VLA-4 blockade mice fed a high-fat diet attenuated liver improve...
Abstract Non-alcoholic steatohepatitis (NASH) is characterized by steatosis with lobular inflammation and hepatocyte injury. Pirfenidone (PFD) an orally bioavailable pyridone derivative that has been clinically used for the treatment of idiopathic pulmonary fibrosis. However, it remains unknown whether PFD improves liver fibrosis in a mouse model human NASH-like phenotypes. In this study, we employed melanocortin 4 receptor-deficient (MC4R-KO) mice as phenotypes to elucidate effect action...
Major depressive disorder (MDD) presumably includes heterogeneous subgroups with differing pathologies. To obtain a marker reflecting such subgroup, we analyzed the cerebrospinal fluid (CSF) levels of fibrinogen, which has been reported to be elevated in plasma patients MDD. Three fibrinogen-related proteins were measured using aptamer-based analyses and CSF samples 30 MDD controls. The numbers an excessively high level (>99 percentile controls) was significantly increased (17 23%)....
Despite an aggressive multimodal therapeutic regimen, glioblastoma (GBM) continues to portend a grave prognosis, which is driven in part by tumor heterogeneity at both the molecular and cellular levels. Accordingly, herein authors sought identify metabolic differences between GBM core cells edge and, so doing, elucidate novel actionable targets centered on metabolism.
Purpose: Dysregulated cholesterol metabolism is critical in the pathogenesis of AMD. Cellular senescence contributes to development numerous age-associated diseases. In this study, we investigated link between burden and cellular photoreceptors. Methods: Retinas from rod-specific ATP binding cassette subfamily A member 1 (Abca1) G (Abcg1) (Abca1/g1-rod/-rod) knockout mice fed with a high-fat diet were analyzed for signs senescence. Real-time quantitative PCR immunofluorescence used...
When intrathecally or epidurally administered, alpha2-adrenoceptor agonists produce potent antinociception by affecting the activity of primary afferent fibres and spinal cord neurons. Recent reports have indicated that in dorsal root ganglion neurons, tetrodotoxin-resistant Na+ channels play important roles conduction nociceptive sensation. We therefore investigated effects on currents.Using whole-cell patch-clamp technique, we recorded currents from rat neurons.Both clonidine...
The development of efficacious therapies targeting metastatic spread breast cancer to the brain represents an unmet clinical need. Accordingly, improved understanding molecular underpinnings central nervous system and progression metastases (BCBM) is required. In this study, burden disease in BCBM was investigated, as well role aldehyde dehydrogenase 1A3 (ALDH1A3) cascade leading development. Initial analysis survival trends for determined improvement rates; however, has failed positively...
Although paclitaxel is a commonly used anticancer drug, peripheral neuropathy may develop as side effect. Worsening of the symptoms with time cause patients who receive to give up their chemotherapy. Duloxetine, serotonin- and norepinephrine-reuptake inhibitor, has been treat neuropathic pain. We report case 68-year-old man gastric cancer, underwent gastrectomy then received 8 cycles chemotherapy involving weekly administrations paclitaxel. Under this treatment, he complained severe...
The purpose of this study was to investigate the effects interactive learning materials on learners’ self-regulated processes and satisfaction. A two-group experimental design employed for 285 primary school teachers involved in teacher training. Teachers group utilised along with training videos guidelines their self-development at level. control conducted only guidelines. result analysed using theory explaining how one’s self-regulation affect Five were identified study: internal...
Background and objective To examine a possible mechanism for their antinociceptive actions, we compared the effects of two clinically used ultra-short-acting β1-blockers, landiolol esmolol, on tetrodotoxin-resistant sodium (TTX-r Na+) channels in rat dorsal root ganglion neurons, which are important nociception. Methods In small (<30 μm) neurons from Sprague–Dawley rats, recordings whole-cell membrane currents were made using patch-clamp technique. esmolol TTX-r Na+ currents, evoked every 10...
This study aimed to evaluate the relationship between diameters of auditory and eighth cranial nerves improvements in post-implant performance. Twenty prelingually deafened children (aged from 2.0 6.0 years) who received Nucleus 24 cochlear implant participated this study. All subjects had used their for at least 1 year after device connection. The were retrospectively measured on preoperative T2-weighted axial magnetic resonance image (MRI). In 17 20 subjects, could be identified MRI. mean...
Tramadol is a useful analgesic which acts as serotonin and noradrenaline reuptake inhibitor in addition to μ-opioid receptor agonist. Cytoplasmic modulates the small GTPase activity through serotonylation, closely related human platelet activation. We recently reported that combination of subthreshold collagen CXCL12 synergistically activates platelets. herein investigated effect mechanism tramadol on synergistic effect. attenuated stimulated aggregation (300 μM tramadol, 64.3% decrease,...
Abstract Rapamycin slows cystogenesis in murine models of polycystic kidney disease (PKD) but failed clinical trials, potentially due to insufficient drug dosing. To improve efficiency without increasing dose, kidney-specific delivery may be used. Mesoscale nanoparticles (MNP) selectively target the proximal tubules rodents. We explored whether MNPs can cystic and rapamycin-encapsulated-MNPs (RapaMNPs) slow cyst growth Pkd1 knockout (KO) mice. MNP was intravenously administered adult KO...