A5101892295- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Colorectal and Anal Carcinomas
- Metastasis and carcinoma case studies
- Tendon Structure and Treatment
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- Cardiovascular Health and Disease Prevention
- Surgical Simulation and Training
- Gastrointestinal Tumor Research and Treatment
- Genetic factors in colorectal cancer
- Pancreatitis Pathology and Treatment
- Sports injuries and prevention
- Cardiac Arrest and Resuscitation
- Anatomy and Medical Technology
- Chemotherapy-induced cardiotoxicity and mitigation
- Dysphagia Assessment and Management
- Sarcoma Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Spaceflight effects on biology
Gifu University Hospital
2020-2025
Gifu University
2019-2025
University of Yamanashi
2025
Tohoku University
2022-2024
Daiichi-Sankyo (Japan)
2021-2024
Prefectural University of Hiroshima
2014-2023
Showa University Northern Yokohama Hospital
2016-2023
Aomori Prefectural Central Hospital
2019-2022
Toho University Medical Center Sakura Hospital
2013-2021
Toho University
2013-2021
We investigated whether cardio-ankle vascular index (CAVI), an arterial stiffness marker, independently predicts future cardiovascular events in subjects with metabolic disorders.1562 outpatients underwent CAVI between April 2004 and March 2006 at Toho University, Sakura Medical Center Chiba, Japan. Patients who already had baseline, patients low ankle brachial (＜0.9), atrial fibrillation were excluded. After exclusion, 1080 disorders including diabetes mellitus, hypertension dyslipidemia...
Abstract Background HER2-expressing salivary gland carcinoma (SGC) is associated with poor prognosis. Trastuzumab deruxtecan (T-DXd, DS-8201) has shown evidence of antitumor activity for several solid tumors in multiple studies. This study aimed to present the efficacy and safety T-DXd patients SGC from a pooled analysis. Methods Patients were two phase I, open-label studies T-DXd: two-phase, multiple-dose, first-in-human (NCT02564900) single-sequence crossover drug–drug interaction...
Obesity promotes infiltration of inflammatory cells into various tissues, leading to parenchymal and stromal cell interaction development cellular organ dysfunction. Liver sinusoidal endothelial (LSECs) are the first that contact portal blood substances in liver, but their functions obesity-associated glucose metabolism remain unclear. Here, we find LSECs involved accumulation myeloid via VLA-4-dependent cell-cell adhesion. VLA-4 blockade mice fed a high-fat diet attenuated liver improve...
The objective of this study is to investigate the association body mass index (BMI) with arterial stiffness assessed by cardioankle vascular (CAVI).A retrospective cross-sectional was conducted in 23,257 healthy Japanese subjects (12,729 men and 10,528 women, aged 47.1 ± 12.5 years, BMI 22.9 3.4 kg/m2) who underwent health screening between 2004 2006 Japan. Exclusion criteria were current medication use a past history cardiovascular disease, hypertension, stroke, diabetes, nephritis.Male...
We aimed to investigate the effect of resveratrol (Rsv) on expression genes regulating triglyceride (TG) accumulation and consumption in differentiated 3T3-L1 preadipocytes. preadipocytes were cultured DMEM supplemented with 10% fetal calf serum. Upon reaching confluence, cells induced differentiate for 4 days, 10 days TG accumulation, then incubated Rsv (0, 25 or 50 μM) 3 days. was analyzed by Oil Red-O staining. To understand how regulates consumption, changes gene protein expressions...
Postoperative pancreatic fistula (POPF) is a major complication of surgery. Drain fluid amylase concentration (DAC) considered predictive indicator POPF. However, other indicators related to postoperative drain status exist, and the most reliable for predicting POPF remains unclear. The object this study identify single accurate after distal pancreatectomy (DP).This single-institution retrospective included 122 patients who underwent DP. was conducted between 2010 2022 at Gifu University...
The appropriate treatment strategy for esophageal squamous cell carcinoma (ESCC) in older patients remains unclear. efficacy of preoperative chemotherapy using a divided-dose regimen biweekly docetaxel, cisplatin and 5-fluorouracil (DCF) neoadjuvant (NAC) was compared with upfront surgery (US) aged ≥70 years ESCC. present study retrospectively analyzed the multicenter data who received esophagectomy ESCC between January 2015 December 2021. investigated patient prognosis inverse probability...
422 Background: Salvage surgery is defined as an operation for patients with residual or recurrent tumors after definitive chemoradiotherapy (dCRT) > 50 Gy. Although salvage has been considered to improve prognosis, it associated a high incidence of postoperative morbidity and mortality. A previous meta-analysis by Faiz et al. reported anastomotic leakage, pulmonary disorder rates, 90 day-mortality rates 18.6%, 30.2%, 8.8%, respectively. The aim this study was assess the efficacy safety...
Minimally invasive left pancreatectomy (MILP) is increasingly performed worldwide, necessitating the need for improved understanding of vascular anatomy during surgery. However, effect differences in on surgical outcomes remains unclear. In this study, we aimed to evaluate anatomical variations and identify factors that influence open minimally surgery (MIS) outcomes. This was a single-center retrospective study involving 123 patients who underwent (LP). We analyzed correlation between...
The right top pulmonary vein (RTPV) is a rare anatomical variant that arises independently of the superior lobe. It drains behind main bronchus or intermedius and into left atrium another vein. This anomaly poses challenges during subcarinal lymph node dissection in thoracic surgery, such as esophagectomy, owing to risk vascular injury. RTPV mainly located intermediate bronchus; however, reports focusing on these sites are lacking. Herein, we present case esophageal cancer with an was...
Schwannomas arise from Schwann cells of the peripheral nerve sheath. are usually benign, and most them located in head, neck, or distal extremities. The retroperitoneal region is an unusual location for schwannomas. seen adults very rare pediatric population. A 6-year-old boy was referred to our institution with a right abdominal mass. His main complaint intermittent myoclonus his lower limb. Abdominal computed tomography (CT) magnetic resonance imaging scans revealed round-shaped solid mass...
ABSTRACT Introduction Patients with neurogenic bladder secondary to spinal cord injury are at increased risk of developing urothelial carcinoma due urinary tract infections. The contribution HIV infection is unknown in this group patients. Case Presentation A spina bifida male patient macrohematuria and recurrent was detected covered soft tissue thickening clinically diagnosed cT3N2M1. He also infection. Despite the treatment Gemcitabine Cisplatin, he developed infective endocarditis a...
6079 Background: T-DXd is an antibody-drug conjugate composed of anti-HER2 antibody, cleavable tetrapeptide-based linker, and membrane-permeable topoisomerase I inhibitor payload. has been approved for use in the US Japan both breast cancer gastric demonstrated safety efficacy additional solid tumors indications first-in-human (FIH) (J101; NCT02564900) drug-drug interaction (DDI) (A104; NCT03383692) phase 1 studies. Here we present combined subgroup analysis salivary duct carcinoma. Methods:...
Fluorouracil (5FU) is converted to its active metabolite fluoro‑deoxyuridine monophosphate (FdUMP) through the orotate phosphoribosyl transferase (OPRT)‑ribonucleotide reductase (RR) pathway and thymidine phosphatase (TP)‑thymidine kinase (TK) inhibits thymidylate synthase (TS), leading inhibition of (dTMP) synthesis a de novo pathway. We investigated mechanism 5FU resistance strategies overcome it by focusing on metabolism. Colon cancer cell lines SW48 LS174T 5FU‑resistant SW48/5FUR...
The objective of this retrospective, single-institution study was to assess the safety and feasibility reconstruction using subtotal stomach (SS) with esophagectomy for patients esophageal cancer (EC). Although several different gastric-tube-making anastomotic methods have been reported, incidence rate leakage EC surgery is generally reported over 10%. Complications should be avoided, patient quality life (QOL) maintained postoperatively. We used SS hand-sutured cervical esophagus-subtotal...
Abstract Identifying a strategy with strong efficacy against non-inflamed tumours is vital in cancer immune therapy. ERY974 humanized IgG4 bispecific T cell-redirecting antibody that recognizes glypican-3 and CD3. Here we examine the combination effect of chemotherapy (paclitaxel, cisplatin, capecitabine) treatment xenograft model. monotherapy shows minor antitumour on NCI-H446 xenografted tumours, as infiltration ERY974-redirected cells limited to tumour-stromal boundary. However, therapy...