A5044921718- Thermal Regulation in Medicine
- Climate Change and Health Impacts
- Cardiac Arrest and Resuscitation
- Thermoregulation and physiological responses
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Nosocomial Infections in ICU
- Pancreatic and Hepatic Oncology Research
- Mechanical Circulatory Support Devices
- Cancer Genomics and Diagnostics
- Extracellular vesicles in disease
- Hemodynamic Monitoring and Therapy
- Cancer Research and Treatments
- Pancreatitis Pathology and Treatment
- Intensive Care Unit Cognitive Disorders
- Nutrition and Health in Aging
- Infection Control and Ventilation
- Vascular anomalies and interventions
- Metabolomics and Mass Spectrometry Studies
- Peptidase Inhibition and Analysis
- Venous Thromboembolism Diagnosis and Management
- Clinical Reasoning and Diagnostic Skills
- Non-Invasive Vital Sign Monitoring
- Frailty in Older Adults
- Adipose Tissue and Metabolism
Asahikawa Medical University
2017-2025
Hokkaido University Hospital
2023-2025
Hokkaido University
2025
Sapporo University
2025
Sapporo Higashi Tokushukai Hospital
2019
Sapporo City General Hospital
2015-2017
Asahi Kasei (Germany)
2016
Asahikawa City Hospital
2005
Supplemental doses of antithrombin (AT) are widely used to treat sepsis-induced disseminated intravascular coagulation (DIC) in Japan. However, evidence on the benefits AT supplementation for DIC is insufficient. This multicenter retrospective observational study aimed clarify effect using propensity score analyses. Data from 3,195 consecutive adult patients admitted 42 intensive care units severe sepsis treatment were retrospectively analyzed; 1,784 diagnosed with (n = 715, group; n 1,069,...
Pancreatic cancer is associated with a poor prognosis due to challenges in early detection, severe progression of the primary tumor, metastatic lesions, and resistance antitumor agents. However, previous studies have indicated relationship between microbiome pancreatic outcomes. Our study demonstrated that ferrichrome derived from Lactobacillus casei, probiotic bacteria, exhibited tumor‑suppressive effects colorectal gastric cancer, suppressive were stronger than conventional agents, such as...
Heat-related illness is common, but its epidemiology and pathological mechanism remain unclear. The aim of this study was to report current clinical characteristics, prognostic factors, outcomes heat-related in Japan.We undertook a prospective multicenter observational Japan. Only hospitalized patients with were enrolled from 1 July 30 September 2017 2018.A total 763 the study. Median age 68 years (interquartile range, 49-82 years) median body temperature on admission 38.2°C 36.8-39.8°C)....
Abstract Aim Hypothermia‐associated pancreatitis lacks comprehensive understanding owing to limited studies exploring its mechanism, epidemiology, risk factors, and outcomes. We aimed investigate the frequency, characteristics, predictive factors associated with development of acute in patients accidental hypothermia. Methods This study comprised a post hoc analysis data from multicenter prospective observational (ICE‐CRASH study) conducted 36 tertiary emergency hospitals Japan. Patients...
Rapid assessment of severity is crucial for timely intervention and improved patient outcomes in heatstroke (HS). However, existing biomarkers are limited their accuracy accessibility ER settings. A prospective pilot study was conducted to assess urinary liver fatty acid-binding protein (L-FABP) levels using a point-of-care testing (POCT) upon HS. Severity estimated initial Sequential Organ Failure Assessment (SOFA) scores, were measured modified Rankin Scale (mRS) scores. In 78 severe HS...
Hypothermia is a condition in which body temperature falls below 35 °C, resulting from exposure to low environmental temperatures or underlying medical conditions. Postmortem examinations have revealed increased levels of fatty acids blood and lipid droplet formation renal tubules during hypothermia. However, the causes implications these findings are unclear. This study aimed analyze biological significance phenomena through lipidomics transcriptomics analyses specimens emergency...
Extracorporeal membrane oxygenation (ECMO) indications in patients with accidental hypothermia (AH) and hemodynamic instability before cardiac arrest (CA) are unclear. We aimed to identify a subgroup of these who would benefit from ECMO rewarming. This study was post-hoc analysis the ICE-CRASH (2019–2022), prospective, multicenter, observational throughout Japan. Among 499 (core temperature < 32 °C, age > 18 years), 175 AH were selected. The primary outcome 28-day mortality. examined effect...
Severe sepsis is a major concern in the intensive care unit (ICU), although there very little epidemiological information regarding severe Japan. This study evaluated 3195 patients with 42 ICUs throughout The had mean age of 70 ± 15 years and Acute Physiology Chronic Health Evaluation II score 23 9. estimated survival rates at 28 90 days after ICU admission were 73.6 56.3 %, respectively.
The Japanese Association for Acute Medicine Committee recently proposed a novel classification system the severity of heat-related illnesses. illnesses are simply classified into three stages based on symptoms and management or treatment. Stages I, II, III broadly correspond to heat cramp syncope, exhaustion, stroke, respectively. Our objective was examine whether this is useful in diagnosis by healthcare professionals patients with severe illness organ failure. A nationwide surveillance...
The administration of low-dose intravenous immunoglobulin G (IVIgG) (5 g/day for 3 days; approximate total 0.3 g/kg) is widely used as an adjunctive treatment patients with sepsis in Japan, but its efficacy the reduction mortality has not been evaluated. We investigated whether IVIgG associated clinically important outcomes including intensive care unit (ICU) and in-hospital mortality.This a post-hoc subgroup analysis data from retrospective cohort study, Japan Septic Disseminated...
Appropriate critical care delivery for Coronavirus disease 2019 (COVID-19) is a cornerstone in saving lives. Earlier publications worldwide demonstrate higher mortality among patients receiving mechanical ventilation intensive units during "surges" the number of cases. In contrast, lower outcomes are evident Japan using CRISIS [CRoss Icu Searchable Information System] data by national registry, ECMOnet COVID-19. This highlights need scientific analysis medical factors contributing to high...
This study describes the clinical characteristics and outcomes as well prognostic factors of patients with accidental hypothermia (AH) using Japan's nationwide registry data.The Hypothermia 2018 2019, which included aged 18 years or older a body temperature 35°C less, was multicenter conducted at 87 89 institutions throughout Japan, data collected from December to February 2019 2020, respectively.In total, 1363 were enrolled in registry, 1194 analyzed this study. The median (interquartile...
Background: Currently, it remains controversial whether the Sepsis-3 definition provides most appropriate criteria for clinical use. The purpose of this study was to compare between Sepsis-2 and definitions using Japan’s nationwide registry. Methods: Data were obtained from a multicenter registry conducted at 42 intensive care units (ICUs) throughout Japan, in which patients received treatment severe sepsis or septic shock January 2011 December 2013. Results: A total 2797 diagnosed included...
Abstract In this study, we aimed to develop and validate a machine learning-based mortality prediction model for hospitalized heat-related illness patients. After 2393 patients were extracted from multicentered registry in Japan, subjects divided into the training set development (n = 1516, data 2014, 2017–2019) test 877, 2020) validation. Twenty-four variables including characteristics of patients, vital signs, laboratory at hospital arrival trained as predictor features learning. The...
This multicenter retrospective observational study aimed to evaluate the efficacy of extracorporeal membrane oxygenation (ECMO) support for septic patients with severe respiratory failure using propensity score analyses.The data sepsis from 42 intensive care units between January 2011 and December 2013 were retrospectively collected. Propensity matching analyses undertaken with/without veno-venous ECMO support. The main outcome was in-hospital all-cause mortality.Of 3195 sepsis, 570 had...
Background Despite advances in the diagnosis of pancreatic ductal adenocarcinoma (PDA), histological evaluation small and poorly defined masses pancreas is uncomfortable unsafe. Methods We herein report a case early stage PDA, which multiple KRAS mutations were detected juice preoperatively. A hypoechoic area adjacent to portal vein was through endoscopic ultrasound body. evaluated using plasma, by digital PCR. Results Pancreatic duct biopsy cytology performed with no evidence malignancy;...
Abstract Background Supraphysiologic oxygen administration causes unfavorable clinical outcomes in various diseases, including traumatic brain injury, post–cardiac arrest syndrome, and acute lung injury. Accidental hypothermia is a critical illness that reduces demands, excessive likely to emerge. This study aimed determine whether hyperoxia would be associated with increased mortality patients accidental hypothermia. Methods A post-hoc analysis of nationwide multicenter prospective...
Abstract Background and study aims Needle tract seeding during endoscopic ultrasound fine-needle biopsy (EUS-FNB) remains a concern. We investigated whether such occurred in patient with pancreatic ductal adenocarcinoma (PDA). Patient methods Surgically resected EUS-FNB-derived specimens were genotyped to determine if gastric wall tumor that emerged 3 years after curative resection of an early-stage PDA was clonally related the original tumor. Results The histologically resembled primary...
To assess heat stroke and exhaustion occurrence response during the coronavirus disease 2019 pandemic in Japan.This retrospective, multicenter, registry-based study describes compares characteristics of patients between months July September 2020. Factors affecting were statistically analyzed. Cramér's V was calculated to determine effect size for group comparisons. We also investigated prevalence mask wearing details different cooling methods.No significant differences observed In both...