A5023590306- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Acute Kidney Injury Research
- SARS-CoV-2 and COVID-19 Research
- Mechanical Circulatory Support Devices
- Respiratory Support and Mechanisms
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hemodynamic Monitoring and Therapy
- Trauma and Emergency Care Studies
- Neonatal and Maternal Infections
- Long-Term Effects of COVID-19
- Cardiac Structural Anomalies and Repair
- Blood transfusion and management
- Cardiac Arrest and Resuscitation
- Inflammation biomarkers and pathways
- COVID-19 and healthcare impacts
- Diabetes and associated disorders
- Antibiotics Pharmacokinetics and Efficacy
- Pelvic and Acetabular Injuries
- Antifungal resistance and susceptibility
- S100 Proteins and Annexins
- Venous Thromboembolism Diagnosis and Management
- Single-cell and spatial transcriptomics
- Dialysis and Renal Disease Management
- Blood Coagulation and Thrombosis Mechanisms
Fukuoka University
2015-2025
Osaka University
2024
Fukuoka University Hospital
2016-2023
Tokyo University of Science
2018
Tokyo Medical University Hachioji Medical Center
2016
University of California, San Diego
2016
Definitive guidelines for anticoagulation management during veno-venous extracorporeal membrane oxygenation (VV ECMO) are lacking, whereas bleeding complications continue to pose major challenges.
Sepsis is one of the most significant causes mortality in intensive care units. It indicates crosstalk between inflammation and coagulation. In this study, we aimed to identify prognostic markers among sepsis biomarkers coagulation/fibrinolysis markers. Patients with according Sepsis-3 criteria were enrolled from January 2013 September 2015. Univariate multivariate logistic regression analyses performed an independent predictive marker 28-day on ICU admission. Receiver operating...
C-type lectin-like receptor 2 (CLEC-2) is a platelet-activated expressed on the surface of platelet membranes. Soluble CLEC-2 (sCLEC-2) has been receiving attention as predictive marker for thrombotic predisposition. The present study examined relationship between sCLEC-2 level and degree coagulation disorder in septic patients. Seventy patients were divided into sepsis-induced disseminated intravascular (DIC) (SID) group (n = 44) non-SID 26). levels compared two groups. Because we suspected...
The purpose of this study was to investigate whether polymyxin B hemoperfusion (PMX-HP) improves the survival patients with septic shock. This a retrospective, multicenter conducted on treated during 3-year period. We performed propensity-score analyses Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) database. included data 1723 shock aged 16 years or older. Furthermore, we divided into PMX-HP- and non-PMX-HP-treated groups. primary endpoint all-cause hospital mortality;...
Augmented renal clearance (ARC) of circulating solutes and drugs has been recently often reported in intensive care unit (ICU) patients. However, only few studies on ARC have Japan. The aims this pilot study were to determine the prevalence risk factors for Japanese ICU patients with normal serum creatinine levels evaluate association between estimated glomerular filtration rate (eGFR) calculated using equation. We conducted a prospective observational from May 2015 April 2016 at emergency...
Assessment blood consumption and trauma-associated severe hemorrhage scores are useful for predicting the need massive transfusion (MT) in trauma patients. However, fibrinogen (Fbg) base excess (BE) levels might also be indicators MT. We evaluated accuracy of prediction MT scoring system vs. Fbg BE.The subjects this retrospective single center observational study were patients with injury severity score ≥16 trauma, divided into a non-MT group an group. compared variables, including...
Appropriate critical care delivery for Coronavirus disease 2019 (COVID-19) is a cornerstone in saving lives. Earlier publications worldwide demonstrate higher mortality among patients receiving mechanical ventilation intensive units during "surges" the number of cases. In contrast, lower outcomes are evident Japan using CRISIS [CRoss Icu Searchable Information System] data by national registry, ECMOnet COVID-19. This highlights need scientific analysis medical factors contributing to high...
Abstract Few studies have investigated the relationship between blood type and trauma outcomes according to of injury. We conducted a retrospective multicenter observational study in twelve emergency hospitals Japan. Patients with isolated severe abdominal injury (abbreviated scale for abdomen ≥ 3 that other organs < 3) occurred 2008 2018 were divided into four groups type. The association mortality, ventilator-free days (VFD), total transfusion volume evaluated using univariate...
A healthy 35-year-old man was admitted to a rural hospital with coronavirus disease (COVID-19). During 14 days of hospitalization, he had no symptoms and not given supplemental oxygen. About 3 weeks after discharge, re-admitted the same new-onset continuous fever general weakness. At time his second admission, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) RT-PCR performed on retro-nasal swab result negative. Four patient transferred our intensive care unit (ICU) following...
Recently, augmented renal clearance (ARC), which accelerates glomerular filtration of renally eliminated drugs thereby reducing the systemic exposure to these drugs, has started receive attention. However, clinical features associated with ARC are still not well understood, especially in Japanese population. This study aimed evaluate characteristics and outcomes patients infections intensive care unit (ICU) settings. We conducted a retrospective observational from April 2013 May 2017 at two...
Procalcitonin (PCT) and presepsin (PSEP) are useful biomarkers for diagnosing sepsis; however, elevated PCT PSEP levels may be observed in conditions other than sepsis. We hypothesised that could increase after severe traumatic injuries. Trauma patients with an Injury Severity Score of ≥16 from October 2013 to September 2015 were enrolled our study. examined their positive rates on days 0 1. 1 compared. Risk factors increasing sepsis biomarker identified by multivariate logistic regression...
The purpose of this study was to classify patients with severe COVID-19 into more detailed risk groups using coagulation/fibrinolysis, inflammation/immune response, and alveolar/myocardial damage biomarkers, as well identify prognostic markers for these patients. These biomarkers were measured every day eight intensive care unit days in 54 adult COVID-19. classified survivor (n = 40) non-survivor 14) groups. Univariate multivariate analyses showed that the combined measurement platelet count...
Our previous report indicated that plasminogen activator inhibitor-1 (PAI-1) levels of ≥83 ng/mL in patients with sepsis tended to be associated disseminated intravascular coagulation (DIC), suppressed fibrinolysis, multiple organ dysfunction, and mortality. Therefore, the present study aimed validate whether 83 was a useful cut-off value for using PAI-1 predict poor prognosis sepsis.Patients were included this single-center retrospective study. The classified as having high or low values...
Candidaemia, recognised as a fairly common disease among intensive care unit (ICU) patients, carries poor prognosis. However, studies on the prognostic factors associated with candidaemia in ICU patients are limited, this study aimed to establish best factor for tertiary hospital Japan.We conducted retrospective cohort of emergency at Fukuoka University Hospital, Fukuoka, Japan, from April 2010 March 2015. Demographic and clinical data was collected patients' medical records laboratory...
Abstract Background Sepsis occurs as a result of dysregulated host response to infection. However, cytokine adsorption therapy may restore the balance proinflammatory and anti-inflammatory mediator responses in patients with sepsis. This study aimed determine ability two different types continuous renal replacement (CRRT) hemofilters for polyethyleneimine-coated polyacrylonitrile (AN69ST) (surface-treated) polymethylmethacrylate (PMMA) CRRT. Methods We performed randomized controlled trial...
Abstract The administration of recombinant human soluble thrombomodulin (rhsTM) significantly improves liver inflammation and increases the survival rate patients with acute failure (ALF). However, rhsTM is dose-dependently correlated to risk bleeding. Recently, ultrasound (US) was found enhance effect various drugs. Thus, present study aimed determine enhancement US irradiation on in ALF. (1 mg/kg) MHz, 0.3 W/cm 2 ) were irradiated lipopolysaccharide/D-galactosamine-induced ALF mice model....
Background: The effectiveness of surveillance to identify extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) carriers is controversial during a non-outbreak situation. We performed additional stool cultures for ESBL-E among intensive care unit (ICU) patients already under active by means sputum and urine cultures. aimed assess the efficacy screening in Methods: conducted retrospective cohort study an ICU. Sputum samples were cultured purposes from January September 2013...
To evaluate risk factors for bleeding events in coronavirus disease 2019 (COVID-19) patients on extracorporeal membrane oxygenation (ECMO) and to share the initial results of transcatheter arterial embolization (TAE) hemostasis.Forty-three COVID-19 who received ECMO from May 2020 September 2021 were enrolled this study. Patients with sudden onset anemia immediately underwent computed tomography assess bleeding. We compared laboratory data, duration ECMO, hospitalization period, fatality...
今回,重症新型コロナウィルス2019(Coronavirus disease 2019: COVID-19)患者の凝固線溶異常について,若干の知見を得たので報告する.症例は6症例で,ICU入室から8日間の経過で血小板数が10×104/mm3未満に低下したのは1例のみであった.prothrombin time-international normalized ratio(PT-INR)は経過を通じて概ね正常で,activated partial thromboplastin time(APTT)は経過中5例で正常上限を上回ったが,1例を除き大きく延長する事は無かった.一方,FDPとD-dimerは経過中,正常上限を超えて推移し,2例は第7病日以降に著明な再上昇を来した.以上より,重症COVID-19患者は感染症にも関わらず,凝固線溶異常は「線溶抑制型」でなく,あたかも「線溶亢進型」の様相を呈していた.6例中4例がJapanese Association for Acute Medicine criteria(JAAM)disseminated intravascular...