A5088158196- Neuroinflammation and Neurodegeneration Mechanisms
- Nausea and vomiting management
- Advanced Glycation End Products research
- Acute Ischemic Stroke Management
- Antimicrobial Resistance in Staphylococcus
- Colorectal Cancer Surgical Treatments
- Pharmacological Effects and Toxicity Studies
- Chemotherapy-induced organ toxicity mitigation
- Pharmacy and Medical Practices
- Pathogenesis and Treatment of Hiccups
- Bacterial Identification and Susceptibility Testing
- Anesthesia and Pain Management
- Occupational and environmental lung diseases
- Pleural and Pulmonary Diseases
- Sepsis Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Cannabis and Cannabinoid Research
- Fluid Dynamics and Turbulent Flows
- Antibiotic Use and Resistance
- Stoma care and complications
- Dialysis and Renal Disease Management
- Hepatocellular Carcinoma Treatment and Prognosis
- Neurological Disorders and Treatments
- Magnesium in Health and Disease
- Acute Kidney Injury Research
Fukuoka University
2016-2025
Jikei University School of Medicine
2005-2025
Massachusetts General Hospital
2022-2025
Harvard University
2022-2025
Fukuoka University Hospital
2014-2024
Kyushu University Beppu Hospital
2024
Jichi Medical University Saitama Medical Center
2021
National Hospital Organization
2021
Nagasaki Medical Center
2021
National Kyushu Medical Center
2021
The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is a novel immuno-nutritional biomarker based on the levels of CRP, serum albumin, and lymphocyte count. This study examined prognostic value CALLY in patients with colorectal cancer undergoing curative surgery.
Glial scarring is traditionally thought to be detrimental after stroke. But emerging studies now suggest that reactive astrocytes may also contribute neurovascular remodeling. Here, we assessed the effects and mechanisms of metabolic inhibition in a mouse model stroke recovery. Five days onset, were metabolically inhibited with fluorocitrate (FC, 1 nmol). Markers (glial fibrillary acidic protein (GFAP), HMGB1), markers remodeling (CD31, synaptophysin, PSD95), behavioral outcomes (neuroscore,...
Background HMGB1 (high-mobility group box 1) is known to worsen the functional prognosis after cerebral ischemia. Hp (haptoglobin) binds and sequesters HMGB1. Furthermore, Hp-HMGB1 complexes are rapidly cleared by scavenger receptors on macrophages/microglia modulate polarization of toward M2 phenotype. Therefore, may prevent aggravation ischemia promote tissue repair macrophages/microglia. The aim this study was investigate effects ischemic brain damage induced a high systemic level in mice...
Background: Recent studies indicate that minimally invasive surgery is widely accepted as the optimal procedure for colorectal cancer. However, ideal lo-cation of specimen extraction site remains unclear. This study aimed to compare conventional periumbilical midline incision with Pfannenstiel during rectal Methods: retrospective cohort included 76 patients who underwent (double-stapling technique anastomosis) cancer between January 2022 and June 2023. Postoperative short- mid-term outcomes...
Abstract The concept of the neurovascular unit emphasizes importance cell-cell signaling between neural, glial, and vascular compartments. In neurogenesis, for example, brain endothelial cells play a key role by supplying trophic support to neural progenitors. Here, we describe surprising phenomenon where may release trans-differentiation signals that convert astrocytes into progenitor in male mice after stroke. After oxygen-glucose deprivation, microvesicles containing pro-neural factor...
Therapeutic administration of mitochondria has been increasingly explored. However, how these administered impact immune response remains to be fully addressed. In this proof-of-concept study, we show that extracellularly added cultured peritoneal macrophages increase phagocytosis and recycling exocytosis amplifies neuroplasticity mediated by recycled transfer. Macrophage activation markers such as Nos2 , Arg1 Cd163 were unchanged at 3 h post-treatment with mitochondria, but whole or...
Background: Recent studies indicate that minimally invasive surgery is widely accepted as the optimal procedure for colorectal cancer. However, ideal location of specimen extraction site remains unclear. This study aimed to compare conventional periumbilical midline incision with Pfannenstiel during rectal Methods: retrospective cohort included 76 patients who underwent (double-stapling technique anastomosis) cancer between January 2022 and June 2023. The postoperative short- mid-term...
Abstract Extracellular mitochondria are present and act as non-cell-autonomous signals to support energetic homeostasis. While allograft is a promising approach in rescuing neurons, glia, vascular cells CNS injury disease, there profound limitations cellular uptake of together with the efficacy. Here, we modified by coating them cationic DOTAP mixed DOPE via inverted emulsion method improve mitochondrial transfer We initially optimized using control microbeads liposomes followed isolated...
Cannabidiol decreases cerebral infarction and high-mobility group box1 (HMGB1) in plasma ischemic early phase. However, HMGB1 levels delayed phase reach higher concentration with the progressing brain injury. In this study, we investigated therapeutic time window of cannabidiol on functional deficits, glial a 4 h mouse middle artery (MCA) occlusion model. Cannabidiol-treated mice were divided into 3 groups as follows: (a) treated from day 1, (b) 3, (c) 5 after MCA occlusion. Moreover,...
The objective of this study was to evaluate the effects earlier intervention by an antimicrobial stewardship team (AST) on use, resistance rates, and clinical outcomes, without changing weekly schedule.A retrospective conducted at Fukuoka University Hospital between April 2013 March 2016. were compared among three periods (SP): SP1 (patients receiving anti-methicillin-resistant Staphylococcus aureus agents carbapenems for ≥14 days), SP2 specific antimicrobials SP3 regardless duration...
Abstract Background Transplantation of mitochondria is increasingly explored as a novel therapy in central nervous system (CNS) injury and disease. However, there are limitations safety efficacy because vulnerable extracellular environments damaged can induce unfavorable danger signals. Methods Mitochondrial O-GlcNAc-modification was amplified by recombinant O-GlcNAc transferase (OGT) UDP-GlcNAc. O-GlcNAcylated mitochondrial proteins were identified mass spectrometry the antiglycation...
Abstract Background Patients with lung cancer who are treated carboplatin-based chemotherapy regimens often experience chemotherapy-induced nausea and vomiting (CINV). However, knowledge on the effect of regimen cofactors risk CINV is limited. This study aimed to analyze compare incidence between patients undergoing carboplatin plus pemetrexed (CBDCA+PEM) those paclitaxel (CBDCA+PTX) chemotherapy. Methods Pooled data 240 from two prospective observational studies were compared using...
Abstract Considering the cost and invasiveness of monitoring postoperative minimal residual disease (MRD) colorectal cancer (CRC) after adjuvant chemoradiotherapy (ACT), we developed a favorable approach based on methylated circulating tumor DNA to detect MRD radical resection. Analyzing public database, identified promoter regions genes FGD5 , GPC6 MSC . Using digital polymerase chain reaction (dPCR), termed “amplicon sites using specific enzyme” assay as “AMUSE.” We examined 180 114 pre‐...
Abstract Cisplatin (CDDP)-induced nephrotoxicity is a common dose-limiting toxicity, and diuretics are often administered to prevent nephrotoxicity. However, the efficacy optimal administration of in preventing CDDP-induced remain be established. This study aimed evaluate combining furosemide mannitol was post-hoc analysis pooled data from multicenter, retrospective, observational study, including 396 patients who received one or two for CDDP-based chemotherapy, compared using propensity...