A5056881700- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Organ Donation and Transplantation
- Gallbladder and Bile Duct Disorders
- Renal Transplantation Outcomes and Treatments
- Hepatitis C virus research
- Pancreatitis Pathology and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Nutrition and Health in Aging
- Transplantation: Methods and Outcomes
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Hepatitis B Virus Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Esophageal and GI Pathology
- Liver Diseases and Immunity
- Liver physiology and pathology
- Clinical Nutrition and Gastroenterology
- Congenital Anomalies and Fetal Surgery
- Colorectal Cancer Surgical Treatments
Jikei University School of Medicine
2020-2025
Kyushu University
2015-2024
Korea University
2024
Teikyo University
2024
The University of Texas Southwestern Medical Center
2023
The Jikei University Hospital
2020-2023
Beijing Tsinghua Chang Gung Hospital
2023
Tsinghua University
2023
Methodist Hospital
2023
King's College Hospital
2023
In Brief Objective: To clarify the prognostic value of preoperative blood neutrophil-to-lymphocyte ratio (NLR) in patients undergoing hepatectomy for hepatocellular carcinoma (HCC). Background: Although a high NLR has been reported to be predictor poor survival with various cancers, it not extensively examined HCC. Methods: This retrospective study enrolled 958 who underwent without therapy HCC from 1996 2009. Clinicopathological parameters, including NLR, were evaluated identify predictors...
The aims of this study were to investigate sarcopenia as a novel predictor mortality and sepsis after living donor liver transplantation (LDLT) evaluate the effects early enteral nutrition on patients with sarcopenia. Two hundred four undergoing preoperative computed tomography within month before LDLT retrospectively evaluated. lengths major minor axes psoas muscle simply measured at caudal end third lumbar vertebra, area was calculated. A lower than 5th percentile for healthy donors each...
Because many patients who did not meet the Milan criteria have survived long after undergoing living donor liver transplantation (LDLT), extended for recipient with hepatocellular carcinoma (HCC) are therefore considered to be necessary.A total of 90 consecutive adult LDLT recipients HCC between 1996 and 2007 were reviewed. The recurrence-free survival rates all 86.0%, 81.3%, 81.3% at 1, 3, 5 years, respectively. Fourteen developed a recurrence tumor LDLT. recurrences diagnosed within 1 year...
Initial graft function following liver transplantation is a major determinant of postoperative survival and morbidity. Primary nonfunction (PNF) uncommon; however, it one the most serious life-threatening conditions in immediate period. The risk factors associated with PNF short-term outcome have been previously reported, but there are no reports long-term follow-up after retransplant for PNF. At our institution, 52 transplants had (2.22%) among 2,341 orthotopic 2,130 patients from 1984 to...
Vascular invasion of hepatocellular carcinoma (HCC) has a high incidence recurrence after liver transplantation. Patients with microvascular (MVI) show tumor grade; however, some good prognosis. This retrospective study aimed to investigate whether the degree MVI affects prognosis living-donor transplantation.A total 142 patients HCC who had undergone transplantation were histologically evaluated about number invaded vessels and maximum invading cells. classified into two subgroups: group (n...
Aim The present study investigated the effect of sarcopenia on short‐ and long‐term surgical outcomes identified potential prognostic factors for hepatocellular carcinoma (HCC) following hepatectomy among patients 70 years age older. Methods Patient data were retrospectively collected 296 consecutive who underwent HCC with curative intent. Patients assigned to two groups according (younger than years, older), presence sarcopenia. clinicopathological, outcome, survival analyzed. Results...
Background and Aims We investigated the prognostic value of programmed death ligand 1 (PD‐L1) expression, tumor‐infiltrating CD8‐positive T‐cell status, their combination in hepatocellular carcinoma (HCC). Their association with PD‐L1 expression vascular formation was further explored. Approach Results Using a database 387 patients who underwent hepatic resection for HCC, immunohistochemical staining PD‐L1, CD8, CD34 performed. Additionally, we undertook an enzyme‐linked immunosorbent assay...
Hepatic stellate cells (HSCs) play a central role in hepatic fibrosis and are regulated by Kupffer (KCs). Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+ -M2BP) was recently identified as serum marker for fibrosis. Although WFA+ -M2BP ligand of Mac-2, the function remains unclear.Liver specimens were obtained from five patients with cirrhosis, chronic hepatitis, without kinetics evaluated histologically subpopulations liver such HSCs, KCs, endothelial cells, biliary...
To ensure donor safety in adult-to-adult living liver transplantation, we established a selection criterion for donors which left lobe (LL) was the first choice of graft.Two hundred six consecutive were retrospectively studied. Donors divided into two groups according to graft type: LL (n=137) and right (RL) (n=69).Although mean intraoperative blood loss significantly increased compared with RL, peak postoperative total bilirubin levels duration hospital stay after surgery less than RL...
Background. Although graft local infusion (GLI) treatment via the portal vein or hepatic artery has been pivotal strategy in ABO incompatible (ABOi) living donor liver transplantation (LDLT) Japan, procedure is associated with a high rate of catheter-associated complications. Methods. A new ABOi-LDLT protocol implemented using rituximab, intravenous immune globulin (IVIG), plasma exchange (PE), and splenectomy, without GLI, on four patients, since 2007. Three other treated before 2007,...
Autophagy is a homeostatic mechanism that regulates protein and organelle turnover uses the amino acids from degraded proteins to produce adenosine 5′-triphosphate (ATP). We investigated activity of autophagy-associated pathways in liver regeneration after partial hepatectomy (PHx) liver-specific autophagy-related gene 5 (Atg5) knockout (KO) mice. Liver was severely impaired by 70% PHx, with reduction postoperative mitosis, but compensating increase hepatocyte size. PHx induced intracellular...
Abstract Background & Aims The microvascular invasion of cancer cells (mvi) is a good prognostic factor after hepatic resection ( HR ) and liver transplantation for hepatocellular carcinoma HCC ). This study aimed to predict mvi in patients with . Methods We studied 63 hepatectomized who had without any extrahepatic metastases vascular invasion, which were detected during preoperative evaluation. clinicopathological data these analysed presence mvi. A scoring system was designed using...
Hepatocellular carcinoma (HCC) is primarily treated with hepatic resection and/or locoregional therapy. When HCC recurs and further treatment no longer possible owing to poor liver function, transplantation (LT) or living-donor LT (LDLT) considered. The aim of this study was clarify risk factors for tumor recurrence after LDLT in patients recurrent HCC.The comprised 104 who had undergone because end-stage disease HCC. recurrence-free survival rates the were calculated. Risk identified.The...
The hallmark of primary biliary cirrhosis (PBC) is the presence autoreactive T- and B-cell responses that target epithelial cells (BECs). Biliary cell cytotoxicity dependent upon initiation innate immune followed by chronic adaptive, as well bystander, mechanisms. Critical to these mechanisms are interactions between natural killer (NK) BECs. We have taken advantage ability isolate relatively pure viable preparations liver-derived NK cells, BECs, endothelial studied BECs focused on activate...
Small-for-size syndrome (SFSS) is the most significant cause of graft loss after living donor liver transplantation (LDLT), especially left lobe (LL) LDLT in adults. The safety limit applying LL-LDLT adults without severe SFSS with a high rate lethality needs to be determined. A total 207 LL-LDLTs since September 2005 were evaluated analyze risk factors for SFSS, defined as serum bilirubin concentration ≥20.0 mg/dL LDLT. Although there no differences cumulative survival between medium grafts...