A5000312995- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Organ Donation and Transplantation
- Liver physiology and pathology
- Neuroendocrine Tumor Research Advances
- Renal Transplantation Outcomes and Treatments
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Treatments and Studies
- Multiple and Secondary Primary Cancers
- Colorectal and Anal Carcinomas
- Pediatric Hepatobiliary Diseases and Treatments
- Congenital Anomalies and Fetal Surgery
- Transplantation: Methods and Outcomes
- Hepatitis C virus research
- Esophageal and GI Pathology
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
- Lymphoma Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
Kyushu University
2012-2024
Aso Iizuka Hospital
2024
Fukuoka City Hospital
2021-2024
Matsuyama Red Cross Hospital
2018-2023
Saiseikai Fukuoka General Hospital
2020
Kyushu University Hospital
2014
Icahn School of Medicine at Mount Sinai
2013
Novem (Netherlands)
2012
Fukuoka Higashi Medical Center
2009-2011
Oita Prefectural Hospital
2010
Adult left lobe (LL) living donor liver transplantation (LDLT) has not generally been recognized as a feasible procedure because of the problem graft size. The objectives this study were to assess feasibility and short- long-term results adult LL LDLT in comparison with right (RL) LDLT. Data on 200 consecutive LDLTs, including five retransplants, retrospectively compared those 112 RL terms survival, complications morbidity. mean weight standard volume ratio grafts was 38.7% whereas that...
Vascular invasion of hepatocellular carcinoma (HCC) has a high incidence recurrence after liver transplantation. Patients with microvascular (MVI) show tumor grade; however, some good prognosis. This retrospective study aimed to investigate whether the degree MVI affects prognosis living-donor transplantation.A total 142 patients HCC who had undergone transplantation were histologically evaluated about number invaded vessels and maximum invading cells. classified into two subgroups: group (n...
The aim of this study was to clarify the value three-dimensional computed-tomography (3D-CT) volumetry for size matching in living-donor liver transplantation (LDLT).3D-CT applied 25 donors who underwent hepatectomy a living relative needing an orthotopic transplantation. Fifteen patients extended left lobectomy, one patient lateral and nine right lobectomy. 3D-CT imaging performed with workstation ZIO M900 (Zio Software Inc., Tokyo, Japan). estimated volume grafts two-dimensional (2D) 3D...
Background and aims: MicroRNAs are small non-coding RNA molecules that post-transcriptionally regulate gene expression. Liver-specific microRNA-122 (miR-122) has been shown to facilitate the replication of hepatitis C virus (HCV) in human hepatoma cells vitro. However, clinical significance hepatic miR-122 on HCV body is unclear. Methods: Hepatic expression was quantified using quantitative reverse-transcription polymerase chain reaction. We investigated correlation between load liver...
Background. The degree of fatty infiltration in hepatic grafts is known to be an important risk factor for primary graft nonfunction cadaveric liver transplantation. However, the effect steatosis living-donor transplantation (LDLT) has not yet been well defined. In this study, we evaluated impact that on outcome LDLT. Methods. Sixty consecutive donors and recipients who underwent LDLT between October 1996 August 2001 at Kyushu University Hospital were subjects study. pathologic findings...
Small residual liver volume after massive hepatectomy or partial transplantation is a major cause of subsequent dysfunction. We hypothesize that the abrupt regenerative response small remnant responsible for deleterious outcome. To slow down speed, NS-398 (ERK1/2 inhibitor) PD98059 (selective MEK was administered 70% 90% (PH). The effects speed on morphology, portal pressure and survival were assessed. In PH model, treatment suppressed replicative hepatocytes during early phase regeneration,...
Shirabe K, Taketomi A, Morita Soejima Y, Uchiyama H, Kayashima Ninomiya M, Toshima T, Maehara Y. Comparative evaluation of expanded criteria for patients with hepatocellular carcinoma beyond the Milan undergoing living‐related donor liver transplantation. Clin Transplant 2011: 25: E491–E498. © 2011 John Wiley & Sons A/S. Abstract: Objective: To clarify predictive impact transplantation (LT) (HCC) in 54 HCC (MC) from a series 109 consecutive (LDLT) recipients HCC. Methods: Among exceeding...
Graft hepatic arteries (HAs) are usually reconstructed with a recipient HA branch (anatomical reconstruction) in living donor liver transplantation (LDLT). Surgeons often encounter difficulties reconstructing HAs, particularly when artery other than an must be used; this is known as extra-anatomical reconstruction. The outcomes of LDLT recipients reconstruction were retrospectively reviewed. Between October 1996 and 2009, we performed primary 335 times, re-LDLT 8 re-reconstruction 5 times...
Abstract Background The effect of splenomegaly in patients with liver cirrhosis and portal hypertension is not fully understood. This study was designed to determine the laparoscopic splenectomy on haemodynamics these patients. Methods Patients who underwent Kyushu University Hospital from January 2006 March 2009 were evaluated retrospectively. Correlations between splenic size haemodynamics, changes levels vasoactive agents endothelin (ET) 1 nitric oxide metabolites (NOx) before 7–10 days...
The purpose of this study was to determine the outcomes living donor liver transplantation (LDLT) for elderly recipients. We reviewed 411 adult-to-adult LDLT cases, including 46 recipients who were 65 years old or older and 365 less than old. group had a higher proportion females (P = 0.04) smaller body surface area < 0.001) more frequently underwent because hepatitis C hepatocellular carcinoma 0.001). Elderly patients advanced disease with lower Model End-Stage Liver Disease (MELD) scores...
A Roux-en-Y choledochojejunostomy (CDJ) has been the sole method of choice for reconstruction bile duct in living-donor liver transplantation (LDLT) using left-lobe grafts. In this study, we evaluated feasibility duct-to-duct (DD) biliary adult-to-adult LDLT Between October 1996 and 2001, 46 LDLTs left lobe were performed at our institution. The DD (hepaticocholedochostomy) over a T-tube was seven last nine recipients (DD group, n=7), whereas conventional CDJ used remaining cases (CDJ n=39)....
<h3>Hypothesis</h3> Few studies have investigated the results of research focused on living-donor adult liver transplantation. Different characteristics between right- and left-lobe grafts not yet been clarified in Left-lobe graft remains an important option, even recipients. <h3>Setting</h3> A single transplantation center with a long history hepatic resection. <h3>Patients</h3> Forty-five donors received (n = 39) right-lobe 6) grafts. The clinicopathological data for donor, graft,...
Background. Living donor liver transplantation (LDLT) has been performed in adult patients. However, there are a few reports on how recipient age affects the outcome of LDLT. This study assessed LDLT patients aged 60 years or older. Methods. A total 267 were enrolled and classified into two groups: those younger than (younger group, n=210) older (older n=57). The 6-month 1-, 3-, 5-year patient survivals incidence complications compared. Multivariate analysis was to identify risk factors....
Ensuring a good match between donor and recipient is critically important to achieve acceptable graft outcomes after living-donor liver transplantation (LDLT). Our objective was evaluate the product of age Model for End-stage Liver Disease score (D-MELD) as predictor survival LDLT.We retrospectively evaluated records 355 adults who underwent LDLT chronic disease explored relationship D-MELD outcome.High MELD advanced were significantly associated with survival; had strongest association...
To ensure donor safety in living liver transplantation (LDLT), the left and caudate lobe (LL) is preferred graft choice. However, patient prognosis may still be poor even if volume (GV) selection criteria are met. Our aim was to evaluate effects of right (RL) donation when LL Consecutive donors (n = 135) with preoperative volumetric GV/standard (SLV) ≥35% RL remnant were retrospectively studied. Patients divided into 2 groups: graft. Recipient's body surface area (BSA), Model for End-Stage...