A5102725876- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Treatments and Studies
- Metastasis and carcinoma case studies
- Abdominal Trauma and Injuries
- Inflammatory mediators and NSAID effects
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Angiogenesis and VEGF in Cancer
- Eicosanoids and Hypertension Pharmacology
- Gastrointestinal disorders and treatments
- Hernia repair and management
- Cancer, Hypoxia, and Metabolism
- Esophageal and GI Pathology
- Abdominal Surgery and Complications
- Gallbladder and Bile Duct Disorders
- Peptidase Inhibition and Analysis
- Esophageal Cancer Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
National Hospital Organization
2013-2023
Beppu Medical Center
2013-2023
Kyushu University
2007-2017
Fukuoka City Hospital
2009-2017
National Kyushu Medical Center
2003-2011
Clinical Research Institute
2004
Long Beach Medical Center
2000-2002
University of California, Irvine
2000-2002
California State University, Long Beach
2000-2001
Harvard University
2001
Surgical risk of laparoscopic gastrectomy for gastric cancer in high patients was evaluated with E-PASS scoring system.This study based on 63 who underwent gastrectomy; 14 belonging to group (ASA≥3) and 49 classified as low (ASA≤2). Fifty six conventional were used comparison.Intra- postoperative complications found 4 3 patients, respectively. We a significant correlation between score complications. significantly higher than the value group. The estimated in-hospital mortality rate...
Abstract Background and Aim: Balloon‐occluded retrograde transvenous obliteration (B‐RTO) is a new alternative treatment for gastric varices (GVx), but the long‐term efficacy not known. We investigated effects of B‐RTO on rebleeding, prevention first bleeding, mortality occurrence risky esophageal (EVx). Methods: was performed in 68 cirrhotic patients with GVx. Twenty had recent transiently treated by endoscopic Histoacryl injection or balloon tamponade. Forty‐eight likely to bleed, no...
Portal venous thrombosis (PVT) is a potentially fatal complication following splenectomy. Its mechanisms and risk factors are poorly understood, especially in patients with cirrhosis portal hypertension. This study investigated for PVT splenectomy such patients.All consecutive who underwent Kyushu University Hospital between 1998 2004 were included this retrospective study. They divided into two groups based on the presence or absence of postoperative PVT. Preoperative operative compared,...
The aim of this study was to determine the role antithrombin III (AT-III) in portal vein thrombosis (PVT) after splenectomy cirrhotic patients.There is no standard treatment for PVT liver cirrhosis.A total 50 consecutive patients who underwent laparoscopic hypersplenism were enrolled into study. From January 2005 December 2005, 25 received prophylactic anticoagulation therapy operation (AT-III [-] group). 2006 July 2006, administration AT-III concentrates (1500 U/d) on postoperative day...
In order to improve the prognosis of gastric cancer patients, timely identification second primary cancers is considered be a crucial clinical problem.We analyzed clinicopathological data 2250 patients with regard both synchronous and metachronous cancers.Of 95 (4.2%) had cancer. Both colorectal lung were frequently detected, followed by in liver, esophagus breast. Regarding time detection for such cancers, 65% detected synchronously, while more than 80% metachronously. The was negatively...
Portal vein thrombosis (PVT) is one of the most critical disorders in liver disease patients. These patients have imbalance coagulation and inhibition resulting from decreased levels inhibitory factors, such as protein C, S, antithrombin III (AT-III). We designed this randomized, double-blind, placebo-controlled trial comparing safety efficacy AT-III for PVT with those who received no treatment.Eligible were diagnosed association thrombus, without tumor thrombus more than 50% cross-sectional...
Nonsteroidal anti-inflammatory drugs (NSAIDs) block prostaglandin synthesis and impair healing of gastrointestinal ulcers growth colonic tumors, in part, by inhibiting angiogenesis. The mechanisms this inhibition are incompletely explained. Here we demonstrate that both nonselective (indomethacin) COX-2-selective (NS-398) NSAIDs inhibit hypoxia-induced vitro angiogenesis gastric microvascular endothelial cells via coordinated sequential events: 1) increased expression the von Hippel-Lindau...
Controversy exists as to the nature of gastric perfusion in portal-hypertensive gastropathy. To investigate portal hemodynamics and mucosal cirrhotic patients with without gastropathy, we subjected 56 hypertension vein catheterization, pneumatic pressure sensor technique, duplex sonography laser Doppler flowmetry. Thirteen had gastropathy: In 10 it was mild, 3 severe. The presence gastropathy seemed be independent age, sex, cause cirrhosis or grade esophageal varices. Portal venous pressure,...
Abstract Background The effect of splenomegaly in patients with liver cirrhosis and portal hypertension is not fully understood. This study was designed to determine the laparoscopic splenectomy on haemodynamics these patients. Methods Patients who underwent Kyushu University Hospital from January 2006 March 2009 were evaluated retrospectively. Correlations between splenic size haemodynamics, changes levels vasoactive agents endothelin (ET) 1 nitric oxide metabolites (NOx) before 7–10 days...
Aim Sarcopenia is an independent predictor of mortality and sepsis after living donor liver transplantation (LDLT). However, the exact mechanisms by which sarcopenia affects poor prognosis or worse immunity against postoperative are unclear, particularly regarding muscular amino acid metabolism, authors aimed to identify role plasma acids in retrospective study. Methods The area psoas muscle 228 recipients LDLT was retrospectively measured dynamic computed tomography. Additionally, levels...
To evaluate and compare laparoscopic splenectomy partial splenic embolization as supportive intervention for cirrhotic patients with hypersplenism to overcome peripheral cytopenia before the initiation of during interferon therapy or anticancer hepatocellular carcinoma.Between December 2000 April 2008, 43 Japanese underwent either a facilitate completion carcinoma. We reviewed peri- post-intervention outcomes details subsequent planned main therapies. For therapy, rate completion, treatment...
Abstract Background and Aim: We intended to determine whether laparoscopic splenectomy (Lap‐Sp) contributes treatment with interferon therapy in hepatitis C virus (HCV)‐cirrhotic patients thrombocytopenia caused by hypersplenism. Methods: From December 2004 August 2008, 100 cirrhotic (54 men 46 women) underwent Lap‐Sp for a clinical application of therapy. All the were Child–Pugh class A or B (average platelet count, 56 × 10 3 /mm ). The HCV genotype was type 1 80 2 20 patients. Results:...
In liver cirrhosis, down-regulation of endothelial nitric oxide synthase (eNOS) has been implicated as a cause increased intrahepatic resistance. We investigated whether Rho-kinase activation is one the molecular mechanisms involved in defective eNOS signaling secondary biliary cirrhosis. Liver cirrhosis was induced by bile duct ligation (BDL). measured mean arterial pressure (MAP), portal venous (PVP), and hepatic tissue blood flow (HTBF) during intravenous infusion saline (control), 0.3,...