A5054561183- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Liver physiology and pathology
- Hepatitis C virus research
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Transplantation: Methods and Outcomes
- Cancer, Lipids, and Metabolism
- Pluripotent Stem Cells Research
- Nutrition and Health in Aging
- Renal Transplantation Outcomes and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Neuroendocrine Tumor Research Advances
- Clinical Nutrition and Gastroenterology
- Inflammatory Biomarkers in Disease Prognosis
- Renal cell carcinoma treatment
- Tissue Engineering and Regenerative Medicine
- Cancer Immunotherapy and Biomarkers
- Hepatitis B Virus Studies
- Immune Cell Function and Interaction
- Sarcoma Diagnosis and Treatment
Kyushu University
2016-2025
National Kyushu Medical Center
2024-2025
Fukuoka City Hospital
2023
University of Pittsburgh
2015-2022
Kyushu University Beppu Hospital
2020-2021
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital
2011-2018
Japanese Red Cross Hiroshima College of Nursing
2012
Fundación Juan March
2009
In Brief Objective: To clarify the prognostic value of preoperative blood neutrophil-to-lymphocyte ratio (NLR) in patients undergoing hepatectomy for hepatocellular carcinoma (HCC). Background: Although a high NLR has been reported to be predictor poor survival with various cancers, it not extensively examined HCC. Methods: This retrospective study enrolled 958 who underwent without therapy HCC from 1996 2009. Clinicopathological parameters, including NLR, were evaluated identify predictors...
The availability of an autologous transplantable auxiliary liver would dramatically affect the treatment disease. Assembly and function in vivo a bioengineered human derived from induced pluripotent stem cells (iPSCs) has not been previously described. By improving methods for decellularization, recellularization, differentiation different cellular lineages iPSCs organ-like environment, we generated functional engineered mini livers performed transplantation rat model. Whereas previous...
Background and Aims We investigated the prognostic value of programmed death ligand 1 (PD‐L1) expression, tumor‐infiltrating CD8‐positive T‐cell status, their combination in hepatocellular carcinoma (HCC). Their association with PD‐L1 expression vascular formation was further explored. Approach Results Using a database 387 patients who underwent hepatic resection for HCC, immunohistochemical staining PD‐L1, CD8, CD34 performed. Additionally, we undertook an enzyme‐linked immunosorbent assay...
Cancer-related inflammation has been correlated with cancer prognosis. This study evaluated inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR) and lymphocyte-to-monocyte (LMR), programmed death ligand (PD-L) 1 expression, tumour microenvironment in relation to prognosis clinicopathological features of patients hepatocellular carcinoma (HCC) undergoing curative hepatic resection. Patients who had liver resection for HCC 2000–2011 were...
Differentiation of stem cells to hepatocyte-like (HLCs) holds great promise for basic research, drug and toxicological investigations, clinical applications. There are currently no protocols the production HLCs from cells, such as embryonic or induced pluripotent that produce fully mature hepatocytes with a wide range hepatic functions. This report describes standard method assess maturation cell-derived moderately high-throughput format, by analysing liver gene expression quantitative...
The Ras/B-Raf/C-Raf/MEK/ERK signaling cascade is critical for the control of many fundamental cellular processes, including proliferation, survival, and differentiation. This study demonstrated that small interfering RNA-dependent knockdown diacylglycerol kinase eta (DGKeta) impaired pathway activated by epidermal growth factor (EGF) in HeLa cells. Conversely, overexpression DGKeta1 could activate a DGK activity-independent manner, suggesting DGKeta serves as scaffold/adaptor protein. By...
There are unprecedented epidemics of obesity, such as type II diabetes and non-alcoholic fatty liver diseases (NAFLD) in developed countries. A concerning percentage American children being affected by obesity NAFLD. Studies have suggested that the maternal environment utero might play a role development these later life. In this study, we documented inhibiting SIRT1 signaling human fetal hepatocytes rapidly led to an increase intracellular glucose lipids levels. More importantly, both de...
The aim of this study was to investigate the effects preoperative oral supplementation with branched-chain amino acids (BCAAs) on postoperative bacteremia after living donor liver transplantation (LDLT) for chronic failure. Two hundred thirty-six patients who underwent adult-to-adult LDLT were evaluated in retrospective study. divided into 2 groups: those received BCAAs before (the BCAA group; n = 129) and did not non-BCAA 107). Before indication determined, prescribed by a hepatologist...