A5064216654- Protein Degradation and Inhibitors
- Sarcoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Inflammatory Biomarkers in Disease Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Cancer, Lipids, and Metabolism
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Melanoma and MAPK Pathways
- Gallbladder and Bile Duct Disorders
- Advanced Breast Cancer Therapies
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- Cancer Mechanisms and Therapy
- Nutrition and Health in Aging
- Gastric Cancer Management and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Bone and Joint Diseases
- Congenital Anomalies and Fetal Surgery
Jikei University School of Medicine
2020-2025
Kawasaki Medical School
2020
Kawasaki Hospital
2020
Nishi Niigata Chuo National Hospital
2018-2019
National Hospital Organization
2018
Sado General Hospital
2017
Abstract Intimal sarcoma is an extremely rare, life-threatening malignant neoplasm. Murine double minute 2 (MDM2) amplification observed in >70% of intimal sarcomas. Milademetan, MDM2 inhibitor, may provide clinical benefit this patient population. We conducted a phase Ib/II study patients with MDM2-amplified, wild-type TP53 as substudy large nationwide registry for rare cancers Japan. Milademetan (260 mg) was administered orally once daily 3 days every 14 days, twice 28-day cycle. Of...
The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is a novel inflammation-based biomarker, which has been associated with long-term outcomes in patients hepatocellular carcinoma. We aimed to investigate whether the CALLY can predict prognosis for distal cholangiocarcinoma after pancreaticoduodenectomy.
Frailty, represented by sarcopenia and osteopenia, has been associated with worse survival after hepatectomy in patients hepatocellular carcinoma. Recently, the concept term "osteosarcopenia" have proposed, which outcome several malignancies.This study included 227 who underwent elective hepatic resection for Osteopenia was evaluated computed tomographic measurement of pixel density midvertebral core 11th thoracic vertebra. The skeletal muscle index (SMI) psoas areas at third lumbar...
Activating mutations in mitogen-activated protein kinase 1 (MAP2K1) are involved a variety of cancers and may be classified according to their RAF dependence. Sensitivity combined BRAF MEK treatments is associated with co-mutations MAP2K1 BRAF; however, the significance less frequent largely unknown. The transforming potential drug sensitivity 100 variants were evaluated using individual assays mixed-all-nominated-in-one method. In addition, A375, melanoma cell line harboring V600E mutation,...
Intrahepatic cholangiocarcinoma (ICC) has a poor prognosis even after curative-intent hepatic resection due to high recurrence rate. The aim of this study was investigate preoperative risk factors for early surgery ICC, which may help identify patients who need chemotherapy.
Abstract Introduction The purpose of this study was to investigate the relation between preoperative cachexia index (CXI) and long‐term outcomes in patients with colorectal liver metastases (CRLM) after hepatic resection. Method In all,118 who underwent resection for CRLM were analyzed retrospectively. relationship CXI investigated. calculated based on skeletal muscle index, serum albumin level, neutrophil–lymphocyte ratio. Results multivariate analysis showed that extrahepatic lesion...
The 5-5-500 rule has been proposed to increase the candidates of liver transplantation for patients with hepatocellular carcinoma reasonable recurrence rates. However, clinical significance in who underwent hepatic resection not fully investigated.The study comprised 206 had undergone primary between 2008 and 2018. We retrospectively investigated prognostic disease-free, as well overall, survival further stratification using inflammatory-based biomarkers.132 (64%) were classified within...
Abstract Although the inhibition of acid ceramidase (AC) is known to induce antitumor effects in various cancers, there are few reports pancreatic cancer, and underlying mechanisms remain unclear. Moreover, currently no safe administration method AC inhibitor. Here gene therapy using siRNA shRNA for with its cancer were investigated. The by an adeno‐associated virus 8 (AAV8) vector had antiproliferative inducing apoptosis cells xenograft mouse model. Acid elicits mitochondrial dysfunction,...
Lemmel syndrome is a rare condition that leads to cholangitis and/or pancreatitis due intraduodenal diverticulum. Surgery considered for the treatment of severe or repeated symptoms in patients with this condition. An 81-year-old woman was admitted our hospital, complaining general fatigue, BT 38.8 degree, and right hypochondoralgia. Her hepatobiliary enzyme levels were elevated, enhanced abdominal computed tomography revealed dilation common bile duct After restarting oral intake, her...
To study exocrine function of the remnant pancreas after pancreatoduodenectomy (PD), we propose use an index (PEI) that combines volume and intraoperative amylase activity pancreatic juice. Here, aimed to determine whether PEI can predict non-alcoholic fatty liver disease (NAFLD) following PD. Fifty-seven patients for whom juice was measured during PD were enrolled. NAFLD defined as a liver-to-spleen attenuation ratio <0.9 on plain CT 1 year surgery. We retrospectively evaluated clinical...
Aim: The impact of occult vertebral fracture (OVF) on oncological outcomes after surgery has not been investigated, although its significance in orthopedics much debated recently. We evaluated the prognostic OVF long-term patients with colorectal liver metastases (CRLM) hepatectomy. Methods: included 140 CRLM who underwent was identified using quantitative measurement and preoperative sagittal computed tomography image reconstruction from 11th thoracic vertebra to 5th lumber vertebra....
The aim of this study was to investigate the risk factors surgical site infection (SSI) in patients who underwent liver resection for colorectal metastases (CRLM).A total 151 CRLM were included study. We investigated relationship between patient characteristics and perioperative incidence SSI.Nineteen (13%) these developed SSI. Multivariate analysis revealed that modified Glasgow Prognostic Score (mGPS) (1 or 2, odds ratio 3.86, p=0.03) presence an enterostomy (yes, 3.93, p=0.04) significant...