A5087421653- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Immunotherapy and Immune Responses
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Neurofibromatosis and Schwannoma Cases
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Vascular Tumors and Angiosarcomas
- Neuroblastoma Research and Treatments
- Management of metastatic bone disease
- Scoliosis diagnosis and treatment
- Urinary Bladder and Prostate Research
- Liver Disease Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Oral and Maxillofacial Pathology
- Spinal Cord Injury Research
- Cervical and Thoracic Myelopathy
- Musculoskeletal pain and rehabilitation
- Cancer, Lipids, and Metabolism
- Soft tissue tumor case studies
- Bone health and osteoporosis research
- Cardiac tumors and thrombi
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer Immunotherapy and Biomarkers
Fukushima Medical University
2012-2025
Kyoto Prefectural University of Medicine
2019-2025
Kyoto Prefectural Education Center
2023-2025
Kyoto University
2025
PE International (Germany)
2025
Kyoto University Hospital
2025
Hiroshima University
2025
Committee on Publication Ethics
2024-2025
Gwangmyeong Mental Health Welfare Center
2025
Kyushu University
2015-2024
Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue sarcoma with poor prognosis. MPNSTs occur frequently in patients neurofibromatosis type 1 (NF1), which NF1 gene deficiency leads to Ras hyperactivation. activation causes the subsequent of AKT/mTOR and Raf/MEK/ERK pathways regulates cellular functions. However, profiles MAPK are poorly understood. The purposes this study examine correlation between these clinicopathologic or prognostic factors identify candidate target...
BackgroundGiant cell tumor of bone (GCTB) is a rare primary tumor, characterized by osteoclast-like giant cells that express receptor activator nuclear factor-kappa B (RANK), and stromal RANK ligand (RANKL), key mediator osteoclast activation. A RANKL-specific inhibitor, denosumab, was predicted to reduce osteolysis control disease progression in patients with GCTB.Patients methodsSeventeen GCTB were enrolled. Patients treated denosumab at 120 mg every 4 weeks, loading dose on days 8 15. To...
Traumatic spinal cord injury (SCI) brings numerous inflammatory cells, including macrophages, from the circulating blood to lesions, but pathophysiological impact resulting spatiotemporal dynamics of macrophages is unknown. Here, we show that centripetally migrate toward lesion epicenter after infiltrating into wide range cord, depending on gradient chemoattractant C5a. However, lacking interferon regulatory factor 8 (IRF8) cannot and remain widely scattered in injured with profound axonal...
Abstract Background Interactions between tumor and microenvironment determine individual response to immunotherapy. Triple negative breast cancer (TNBC) hepatocellular carcinoma (HCC) have exhibited suboptimal responses immune checkpoint inhibitors (ICIs). Aspartate β-hydroxylase (ASPH), an oncofetal protein associated antigen (TAA), is a potential target for Methods Subcutaneous HCC orthotopic TNBC murine models were established in immunocompetent BALB/c mice with injection of BNL-T3 4 T1...
The efficacy of immune checkpoint inhibitors is limited in refractory solid tumors. T-cell receptor gene-modified T (TCR-T)-cell therapy has attracted attention as a new immunotherapy for cold We first investigated the preclinical and mode action TCR-T cells combined with pullulan nanogel:long peptide antigen (LPA) vaccine mouse sarcoma model that resistant to inhibition. Without lymphodepletion, nanogel:LPA markedly increased number draining lymph node tumor tissue. This change was...
Glyoxal (GO) and methylglyoxal (MGO) are reactive dicarbonyl compounds formed during autoxidation of both carbohydrates lipids. They may react with lysine arginine residues proteins in Maillard or browning reactions, yielding advanced glycation lipoxidation end products. Among these the imidazolium crosslinks, N , (‐di( ϵ ‐lysino))imidazolium (glyoxal‐lysine dimer, GOLD) ‐lysino))‐4‐methyl‐imidazolium (methylglyoxal‐lysine MOLD). We have detected measured GOLD MOLD human serum by...
Translocation t(11;22) is a karyotypic abnormality detected in over 90% of Ewing's family tumors. This translocation results the EWS-Fli1 fusion gene, which has been shown to be potent, single-step transforming gene. We reported previously that suppression protein altered expression G1 regulatory cyclins and cyclin-dependent kinase inhibitors both at mRNA levels, resulting growth arrest tumor cell lines. These data suggest G1regulatory molecules may targets protein, functions as an aberrant...
Myxoid liposarcoma (MLS) is the second most common subtype of liposarcoma, and metastasis occurs in up to one-third cases. However, mechanisms invasion remain unclear. Tumour-associated macrophages (TAMs) have important roles tumour invasion, metastasis, and/or poor prognosis. The aim this study was investigate relationship between TAMs MLS.Using 78 primary MLS samples, association clinical prognosis macrophage infiltration evaluated by immunochemistry. effects on cell growth, motility,...
Abstract Chondrosarcoma is the second most common malignant bone tumor. It characterized by low vascularity and an abundant extracellular matrix, which confer these tumors resistance to chemotherapy radiotherapy. There are currently no effective treatment options for relapsed or dedifferentiated chondrosarcoma, new targeted therapies need be identified. Isocitrate dehydrogenase (IDH) mutations, detected in ~50% of chondrosarcoma patients, contribute transformation catalyzing production...
Abstract Background After spinal cord injury (SCI), glial scarring is mainly formed around the lesion and inhibits axon regeneration. Recently, we reported that anti-β1 integrin antibody (β1Ab) had a therapeutic effect on astrocytes by preventing induction of scar formation. However, cellular components within are not only but also microglia, whether or β1Ab treatment has any influence microglia remains unclear. Methods To evaluate effects after SCI, applied thoracic contusion SCI to...
Real-world evidence regarding enfortumab vedotin for unresectable or metastatic urothelial carcinoma is scarce, particularly in Japan. We investigated real-world data focusing on patient background, previous treatments, response, survival and adverse events patients receiving vedotin.
Despite the recent advances in cancer treatment, incidence of patients with spinal metastases continues to grow along total number patients. Spinal can significantly impair activities daily living (ADL) and quality life (QOL), compared other types bone metastases, as they are characterized severe pain paralysis caused by skeletal-related events. Reduced ADL also lead treatment limitations certain anticancer agents radiation therapy not compatible treatments; thus, leading a shorter...
A chimeric protein, EWS-Fli1, identified in most Ewing's family tumors (EFTs) has been shown to be associated with the tumorigenicity of EFTs. We have previously reported that p21Waf1/Cip1 expression was inhibited by EWS-Fli1 Histone deacetylase inhibitors (HDACIs) are known up-regulate various cells and show promise as a cancer therapy. Here, we demonstrate possible involvement activities both histone acetylation deacetylation, well potential use HDACIs an antitumor agent for novel HDACI,...
There is increasing evidence that heparan sulfate (HS) plays an essential role in various axon guidance processes. These observations, however, have not addressed whether HS required cell autonomously as axonal coreceptor or environmental factor modulates the localization of molecules terrain which growing axons navigate. Here we demonstrate netrin-1-mediated commissural requires cell-autonomous expression neurons vivo . We used Wnt1 –Cre transgene to drive region-specific ablation Ext1 ,...
Diverse functions of microRNAs (miRNAs), including effects on tumorigenesis, proliferation, and differentiation, have been reported, several miRNAs also demonstrated to play an important role in apoptosis. In this study, we investigated the possible that may development chemoresistance Ewing sarcoma/primitive neuroectodermal tumor (EWS).We screened doxorubicin (Dox)-resistant EWS cells identify any distinct miRNA sequences regulate cells. The were evaluated using a chemosensitivity assay....
Objective Several studies have suggested that an elevated neutrophil–lymphocyte ratio (NLR) is associated with a poorer prognosis in patients pancreatic cancer (PC). The correlations between the NLR and immunohistochemical (IHC) analysis regard to of PC remain be elucidated. By using IHC findings, we determined value as prognostic factor PC. Material methods We collected clinico-pathological data 28 consecutive who underwent surgical resection for January 2008 December 2012 at Jikei...