A5067291554- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Management of metastatic bone disease
- Orthopaedic implants and arthroplasty
- Foot and Ankle Surgery
- Bone health and treatments
- Orthopedic Surgery and Rehabilitation
- Structural Load-Bearing Analysis
- Structural Behavior of Reinforced Concrete
- Total Knee Arthroplasty Outcomes
- Bone fractures and treatments
- Tendon Structure and Treatment
- Sports injuries and prevention
- Orthopedic Infections and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Cancer Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Knee injuries and reconstruction techniques
- Hip and Femur Fractures
- Vascular Tumors and Angiosarcomas
- Pluripotent Stem Cells Research
- Concrete Corrosion and Durability
- Bone Metabolism and Diseases
- Spinal Fractures and Fixation Techniques
- Shoulder Injury and Treatment
Teikyo University
2016-2025
Albert Einstein College of Medicine
2005-2024
Montefiore Medical Center
2024
Chiba University
2023
The University of Tokyo
2008-2021
Teikyo University Hospital
2017-2021
Otsuka (Japan)
2021
University of Tokyo Hospital
2011-2020
Keio University Hospital
2020
Kanagawa Prefectural Hospital Organization
2020
As locally converted estrogen from testicular testosterone contributes to apparent androgen activity, the physiological significance of receptor (AR) function in beneficial effects androgens on skeletal tissues has remained unclear. We show here that inactivation AR mice using a Cre-loxP system-mediated gene-targeting technique caused bone loss males but not females. Histomorphometric analyses 8-week-old male knockout (ARKO) showed high turnover with increased resorption resulted reduced...
Testicular testosterone produced during a critical perinatal period is thought to masculinize and defeminize the male brain from inherent feminization program induce male-typical behaviors in adult. These actions of appear be exerted not through its androgenic activity, but rather conversion by aromatase into estrogen, with consequent activation estrogen receptor (ER)-mediated signaling. Thus, role androgen (AR) masculinization underlying expression remains unclear because brain. Here, we...
Androgen receptor (AR) null male mice (ARL−/Y) revealed late-onset obesity, which was confirmed by computed tomography–based body composition analysis. ARL−/Y were euphagic compared with the wild-type (ARX/Y) controls, but they also less dynamic and consumed oxygen. Transcript profiling indicated that had lower transcripts for thermogenetic uncoupling protein 1, subsequently found to be ligand-dependently activated AR. We enhanced secretion of adiponectin, is insulin sensitizing, from...
ABSTRACT The molecular mechanisms underlying the development of external genitalia in mammals have been very little examined. Recent gene knockout studies suggested that developmental processes its anlage, genital tubercle (GT), much common with those limb buds. Fgf genes postulated as regulating several downstream during organogenesis. Fgf8 was expressed distal urethral plate epithelium (GT) together other markers such Msx1, Fgf10, Hoxd13 and Bmp4 mesenchyme. To analyze role FGF system GT...
The physiological and beneficial actions of vitamin D in bone health have been experimentally clinically proven mammals. active form [1α,25(OH)(2)D(3)] binds activates its specific nuclear receptor, the receptor (VDR). Activated VDR prevents release calcium from storage to serum by stimulating intestinal absorption renal reabsorption. However, direct action tissue is poorly understood because Ca(2+) homeostasis maintained through tightly regulated ion transport kidney, intestine, bone. In...
Coronal plane alignment of the knee (CPAK) has recently been proposed as a simple and universal classification system to determine suitability particular phenotype specific strategy for replacement surgery. Although racial differences may affect alignment, there are no reports on distribution this system. We aimed clarify CPAK in patients with osteoarthritis who underwent total arthroplasty (TKA) Japan. Consecutive primary TKA were analyzed retrospectively. The knees categorized according...
This study investigated the actions of fibroblast growth factor (FGF)-18, a novel member FGF family, on osteoblasts, chondrocytes, and osteoclasts compared them with those FGF-2 FGF-10. FGF-18 stimulated proliferation cultured mouse primary osteoblastic MC3T3-E1 cells, prechondrocytic ATDC5 although it inhibited differentiation matrix synthesis these cells. up-regulated phosphorylation extracellular signal-regulated kinase in both osteoblasts chondrocytes p38 mitogen-activated protein only...
Androgen has anabolic effects on cardiac myocytes and been shown to enhance left ventricular enlargement function. However, the physiological patho-physiological roles of androgen in growth stress-induced remodeling remains unclear. We aimed clarify whether androgen-nuclear receptor (AR) system contributes angiotensin II (Ang II)-stimulated by using systemic AR-null male mice. AR knock-out (ARKO) mice, at 25 weeks age, age-matched wild-type (WT) mice were treated with or without Ang...
The Komeda miniature rat Ishikawa (KMI) is a naturally occurring mutant caused by an autosomal recessive mutation mri , which exhibits longitudinal growth retardation. Here we identified the as deletion in gene encoding cGMP-dependent protein kinase type II (cGKII). KMIs showed expanded plate and impaired bone healing with abnormal accumulation of postmitotic but nonhypertrophic chondrocytes. Ex vivo culture KMI chondrocytes reproduced differentiation impairment, was restored introducing...
Osteosarcoma is the most prevalent bone malignant tumor in children and adolescents, displays heterogeneous histology high propensity for distant metastasis. Although adjuvant chemotherapy remarkably improved treatment outcome over past few decades, prognosis osteosarcoma patients with pulmonary metastasis still unsatisfactory. To identify novel therapeutic targets osteosarcoma, we investigated gene expression profile of osteosarcomas by cDNA microarray analysis found transactivation...
Introduction. Disorders of the Achilles tendon can be broadly classified into acute and chronic entities. Few studies have established tendinopathy as a precursor to ruptures. In this study, we assessed relationship between rupture, clarifying incidence rupture in setting underlying tendinopathy. Methods. The United Healthcare Orthopedic Dataset from PearlDiver Patient Record Database was used identify patients with ICD-9 codes for and/or number tendinopathy, following prior diagnosis...
Background. Alveolar soft part sarcoma (ASPS) is a rare tumor, and little information available regarding its clinical features appropriate treatments. Methods. A retrospective review of 26 consecutive ASPS patients (12 male, 14 female; mean age 27 years) treated at our institution over 30 years (mean followup; 71 months) was performed. Results. The primary tumor developed in the lower extremity (12), trunk (8), upper (6), with an average size 7.2 cm (range, 2–14 cm). AJCC stage presentation...
Abstract The genomic characteristics of dedifferentiated liposarcoma (DDLPS) that are associated with clinical features remain to be identified. Here, we conduct integrated whole exome and RNA sequencing analysis in 115 DDLPS tumors perform comparative well-differentiated components from eight samples. Several somatic copy-number alterations (SCNAs), including the gain 12q15, identified as frequent alterations. CTDSP1/2-DNM3OS fusion genes a subset tumors. Based on association SCNAs...
BACKGROUND In this era of individualized cancer treatment, data that could be applied to predicting the survival patients with osteosarcoma are still limited because rarity disease and difficulty in accumulating a sufficient number patients. Therefore, multi‐institutional collaboration was implemented develop externally validate nomograms would predict metastasis‐free (MFS) overall (OAS) for nonmetastatic osteosarcoma. METHODS This study retrospectively examined 1070 treated neoadjuvant...
Importance Training on the proper use of personal protective equipment (PPE) is critical for infection prevention among health care workers. Traditional methods, such as face-to-face and video-based training, can strain resources present challenges. Objective To determine effectiveness 360° virtual reality (VR) training PPE donning doffing compared with video in enhancing skills prospective practitioners. Design, Setting, Participants A blinded, prospective, randomized noninferiority...
The Musculoskeletal Tumor Society (MSTS) scoring system developed in 1993 is a widely used disease-specific evaluation tool for assessment of physical function patients with musculoskeletal tumors; however, only few studies have confirmed its reliability and validity.The aim this study was to validate the MSTS upper extremity (MSTS-UE) Japanese tumors use by others research. Does MSTS-UE have: (1) sufficient internal consistency; (2) adequate construct validity; (3) reasonable criterion...
Tenosynovial giant cell tumor (TSGCT) is a rare neoplasm. Although surgical resection the widely accepted primary treatment for TSGCT, recurrences are frequent, and patients’ joint function may be severely compromised. Previous studies reported that CSF1‐COL6A3 fusion genes were identified in approximately 30% of TSGCTs. The aim our study was to comprehensively clarify genomic abnormalities We performed whole exome sequencing combination with target sequence validation on 34 TSGCT samples....
These clinical practice guidelines are intended to provide recommendations based on the best evidence obtained date key issues in improve prognosis, diagnostic and therapeutic processes for patients with soft tissue tumors.The Guidelines Development Committee Systematic Review were composed of a multidisciplinary team specialists who play an important role tumor care. Clinical questions (CQs) determined by choosing decision-making points Algorithms diagnosis treatment tumors. The developed...