A5102935911- Orthopedic Surgery and Rehabilitation
- Peripheral Nerve Disorders
- Elbow and Forearm Trauma Treatment
- Shoulder Injury and Treatment
- Nerve Injury and Rehabilitation
- Rheumatoid Arthritis Research and Therapies
- Musculoskeletal synovial abnormalities and treatments
- Bone and Joint Diseases
- Botulinum Toxin and Related Neurological Disorders
- Spondyloarthritis Studies and Treatments
- Peripheral Neuropathies and Disorders
- Sarcoma Diagnosis and Treatment
- Shoulder and Clavicle Injuries
- Cell Adhesion Molecules Research
- Systemic Lupus Erythematosus Research
- Central Venous Catheters and Hemodialysis
- Myofascial pain diagnosis and treatment
- Immune Cell Function and Interaction
- Congenital limb and hand anomalies
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Vascular Procedures and Complications
- Osteoarthritis Treatment and Mechanisms
- Advanced Electron Microscopy Techniques and Applications
- Hemostasis and retained surgical items
Kawasaki Hospital
2009-2024
Matsuyama Red Cross Hospital
2023
Toho University
2021-2022
Keio University
1999-2018
Tokyo Dental College Ichikawa General Hospital
2017-2018
Tokyo Women's Medical University
2012-2017
Keio University Hospital
2016
Suzuki (Japan)
2015
Kawasaki Municipal Hospital
2010-2014
Tokyo University of Science
2002-2009
Osteosarcoma is the most prevalent bone malignant tumor in children and adolescents, displays heterogeneous histology high propensity for distant metastasis. Although adjuvant chemotherapy remarkably improved treatment outcome over past few decades, prognosis osteosarcoma patients with pulmonary metastasis still unsatisfactory. To identify novel therapeutic targets osteosarcoma, we investigated gene expression profile of osteosarcomas by cDNA microarray analysis found transactivation...
To establish a method for predicting the response to chemotherapy osteosarcoma (OS), we performed expression profile analysis using cDNA microarray consisting of 23,040 genes. Hierarchical clustering based on profiles 19 biopsy samples OS demonstrated two major clusters, one which consisted exclusively typical OS, i.e. conventional central in long bone patients second decade. A set genes was identified characterize this subgroup, some have previously indicated relation carcinogenesis....
Objective. To describe current trends in the numbers of rheumatoid arthritis (RA)-related surgeries. Methods. The number operations was determined for patients with RA a large observational cohort [Institute Rheumatology, Rheumatoid Arthritis (IORRA)] enrolled from 2001 to 2012. Results. total peaked 2002 and gradually decreased thereafter, but began increase again 2008. knee replacements has since 2003, while wrist foot arthroplasties artificial finger prosthesis surgeries have increased...
Abstract Controlled regeneration of bone or cartilage has recently begun to facilitate a host novel clinical treatments. An osteoblast line, which we isolated is able form new matrix in vivo within 2 days and exhibits mature phenotype both vitro vivo. Using these cells, show that cuboidal bones can be generated into predesigned shaped‐bone with high‐density trabeculae when used combination modified poly‐ DL ‐lactic‐co‐glycolic acid (PLGA)‐collagen sponge. PLGA coated collagen gel serves as...
We have reviewed 38 surgically treated cases of spontaneous posterior interosseous nerve palsy in patients with a mean age 43 years (13 to 68) order identify clinical factors associated its prognosis. Interfascicular neurolysis was performed at 13 months (1 187) after the onset symptoms. The follow-up 21 (5.5 221). Medical Research Council muscle power more than grade 4 considered be good result. A further 12 ten were conservatively and assessed similarly. Of 30 available outcome data,...
There is no definition for fascicular constrictions of the spontaneous anterior interosseous nerve palsy (sAINP) and posterior (sPINP). One surgeon has evaluated his findings in our 32 patients sAINP/sPINP using either photographs or video tapes proposed a definition. All had interfascicular neurolysis, 87 case reports "fascicular constriction" were also evaluated. Fascicular constriction was defined as every instance thinning fascicle regardless to its extent. Thinning result extrinsic...
A cDNA microarray analysis indicated that Semaphorin3B. (20Sema3B), a gene whose product is involved in axon guidance and axonal repulsion, inducible by p53. Introduction of exogenous p53 into glioblastoma cell line lacking wild-type (20U373MG) dramatically induced expression Sema3B mRNA. An electrophoretic mobility shift assay reporter confirmed potential binding site present the promoter region had p53-dependent transcriptional activity. Expression endogenous was response to genotoxic...
Abstract Introduction Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic synovitis that progresses to destruction of cartilage and bone. Bone marrow (BM) cells have been shown contribute this pathogenesis. In study, we compared differentially expressed molecules in BM from RA osteoarthritis (OA) patients analyzed abnormal regulatory networks identify the role RA. Methods Gene expression profiles (GEPs) BM-derived mononuclear 9 10 OA were obtained DNA...
Objective. The aim of this study was to evaluate the associations between potential risk factors and occurrence established vertebral fractures in Japanese patients with rheumatoid arthritis (RA). Methods. A total 10,469 RA were enrolled a prospective, observational from 2000 2011. Self-reported verified using patient's medical records radiographs. Cox proportional hazards models used analyze independent contributions various for fracture occurrence. Results. During mean follow-up 5.8 years,...
Simple decompression of the ulnar nerve at elbow has not been shown to reduce strain in cadavers. In this study, was measured intraoperatively 11 patients with cubital tunnel syndrome, before and after simple decompression. Statistical analysis performed using a paired Student’s t-test. Mean 30.5% (range 9% 69%) 5.5% −2% 11%), respectively; difference statistically significant ( p < 0.01) statistical power 96%. reduced all by an average 24.5%. Our results suggest that pathophysiology...
Embryonal tumors such as Wilms' tumor (WT), embryonal rhabdomyosarcoma (eRMS) and hepatoblastoma have been thought to a common pathogenetic mechanism. H19 was found be inactivated in WT eRMS either by loss of heterozygosity or hypermethylation the maternal allele. We show here that expression gene is allelic 7 out 8 "sporadic" hepatoblastomas. Furthermore, we analyzed IGF2 gene. Loss imprinting detected linked inactivation 2 However, sporadic cases demonstrated monoallelic with Our results...
Journal Article Construct validity, reliability, response rate, and association with disease activity of the quick disabilities arm, shoulder hand questionnaire in assessment rheumatoid arthritis Get access Kensuke Ochi, Ochi Department Orthopaedic Surgery, Institute Rheumatology, Tokyo Women's Medical University, Shinjuku, Tokyo, JapanDepartment School Medicine, Keio Japan Correspondence to: MD, PhD, 10-22 Kawada-cyo, Shinjuku-ku, 162-0054, Japan. Current address:Department University 35...
Objective. Extensor tendon ruptures in the rheumatoid wrist are usually restored by extensor reconstruction surgery. However, factors significantly correlated with outcomes of have not been defined. We examined showing a statistically significant correlation postoperative active motion after reconstruction. Methods. Spontaneous 66 wrists patients (mean age, 52.6 yrs) arthritis (RA) were evaluated. All underwent surgery arthroplasty or arthrodesis. Active ranges affected fingers evaluated at...
Recent reports have suggested that fascicular constriction located proximal to the elbow may be primary aetiology of spontaneous anterior interosseous nerve palsy (sAINP), and recommended interfascicular neurolysis ranging from forearm distal upper arm (wide incision surgery: WIS) for its treatment. On basis these reports, it was hypothesised that, if sAINP constriction, limited (minimal MIS) should similar results those WIS. Twenty-five surgically treated cases were retrospectively...
<b>Background</b> The biomechanical properties of the capitohamate (CH) ligament are equivalent to those scapholunate (SL) interosseous ligament. We reconstructed SL using CH bone-ligament-bone substitute for chronic injury <b>Patients and Methods</b> Beginning in 2008, 15 wrists 14 patients with an average age 38 years underwent this procedure a minimum follow-up 2 years. Thirteen had joint gap more than 3 mm, two complete disruption severe dorsal intercalated segment instability (DISI)...