A5062511223- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Management of metastatic bone disease
- Cancer, Hypoxia, and Metabolism
- Cardiac tumors and thrombi
- Vascular Tumors and Angiosarcomas
- Neuroblastoma Research and Treatments
- Bone health and treatments
- Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Boron Compounds in Chemistry
- Tumors and Oncological Cases
- Soft tissue tumor case studies
- Orthopedic Infections and Treatments
- Neurofibromatosis and Schwannoma Cases
- Knee injuries and reconstruction techniques
- Cell death mechanisms and regulation
- Oral and Maxillofacial Pathology
- Bone and Joint Diseases
- Peptidase Inhibition and Analysis
- Orthopaedic implants and arthroplasty
- Bone fractures and treatments
- RNA Interference and Gene Delivery
- Musculoskeletal synovial abnormalities and treatments
- Medical Imaging and Pathology Studies
Kobe University
2014-2023
Cancer Research Center
2018-2023
Orthopedic One
2023
Kobe University Hospital
2020-2022
Kobe International University
2017-2020
National Clinical Research
2018
Foundation for Physical Medicine and Rehabilitation
2018
Cleveland Clinic
2009-2011
Cleveland Foundation
2009
Kagawa University
2008
The objective of the study was to test hypothesis that platelet-rich plasma (PRP) enhances meniscal tissue regeneration in vitro and vivo. In study, monolayer cell cultures were prepared, 3-(4,5-dimethylthiazol-2yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium inner salt assay 5-bromo-2′-deoxyuridine performed assess proliferative behavior presence PRP. Alcian blue extracellular matrix (ECM) synthesis. To detect fibrocartilage-related messenger ribonucleic acid (mRNA)...
A number of studies have reported that decreased mitochondrial numbers are linked with neoplastic transformation and/or tumor progression, including resistance to apoptosis. Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) is a multi-functional transcriptional coactivator regulates the activities multiple nuclear receptors and factors involved in biogenesis. In this study, we observed mitochondria sarcoma tissues, such as osteosarcoma malignant fibrous...
Abstract Granular cell tumors (GCTs) are rare mesenchymal that exhibit a characteristic morphology and finely granular cytoplasm. The genetic alterations responsible for GCT tumorigenesis had been unknown until recently, when loss‐of‐function mutations of ATP6AP1 ATP6AP2 were described. Thus, we performed whole‐exome sequencing, RNA targeted sequencing 51 samples. From these genomic analyses, identified in genes encoding vacuolar H + ‐ATPase (V‐ATPase) components, including , 33 (65%) GCTs....
Abstract Background Tumor-devitalized autografts treated with deep freezing, pasteurization, and irradiation are biological reconstruction methods after tumor excision for aggressive or malignant bone soft tissue tumors that involve a major long bone. do not require bank, they carry no risk of viral bacterial disease transmission, associated smaller immunologic response, have better shape size match to the site in which implanted. However, disadvantages as well; it is possible assess margins...
Abstract Orthopedic and spine surgeons are in need of supplements or replacements for autograft. We investigated the histological properties three formulations Calcium Sodium Phosphosilicate [calcium sodium phosphosilicate putty with without autograft NovaBone 45S5 Bioglass particulate (NovaBone, LLC, Jacksonville, FL)] using a sheep vertebral bone void model. Bone voids were surgically created L3, L4, L5 each 22 sheep, filled one tested biomaterials left empty as control. Histological...
The AMP-activated protein kinase (AMPK) activator 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) modulates cellular energy metabolism, and promotes mitochondrial proliferation apoptosis. Previous studies have shown that AICAR has anticancer effects in various cancers, however the roles of AMPK and/or on osteosarcoma not been reported. In present study, we evaluated tumor growth apoptosis human both vitro vivo. For experiments, two cell lines, MG63 KHOS, were treated with AICAR,...
Study Design: A prospective cohort study of performance status (PS) and activities daily living (ADL) in patients with spinal metastasis. Objective: To identify the effect surgery on PS ADL Summary Background Data: Spinal metastasis causes severe neurological deficits, resulting drastic loss patients’ ADL. However, spine is not well known. Materials Methods: Seventy were enrolled this study. Forty-six desired underwent (“surgery” group) 24 did desire (“nonsurgery” group). Both groups...
Skeletal related events due to metastatic bone tumors markedly affect the activities of daily living (ADL) and quality life (QOL) in cancer patients. We focused on multidisciplinary therapy for tumors. This study aimed evaluate outcomes surgical treatment extremities.We retrospectively reviewed 114 patients who underwent extremities between 2008 2019 69 were reassessed more than 6 months after surgery. The most common primary tumor was renal, followed by lung, thyroid, breast cancers....
Squamous cell carcinoma (SCC) is the main histological type of oral cancer. Its growth rate and incidence metastasis to regional lymph nodes influenced by various factors, including hypoxic conditions. We have previously reported that transcutaneous CO2 induces mitochondrial apoptosis decreases lung reoxygenating sarcoma cells. However, previous studies not determined sequential mechanism which suppresses epithelial tumors, SCCs. Moreover, there no report lymphogenous using human lines...
Mitochondria play an essential role in cellular energy metabolism and apoptosis. Previous studies have demonstrated that decreased mitochondrial biogenesis is associated with cancer progression. In biogenesis, peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) regulates the activities of multiple nuclear receptors transcription factors involved proliferation. Previously, we showed overexpression PGC-1α leads to proliferation induces apoptosis human malignant...
Osteosarcoma (OS) is a primary malignancy of the bone, with tendency to metastasize early. Despite intensive chemotherapy and surgical resection, more than 30% patients develop distant metastases, prognosis metastases essentially poor. Members protein kinase D (PKD) family are serine/threonine kinases, have been studied in various cancers. Among three different isoforms this family, PKD1 one best understood for its role human malignancies; however, musculoskeletal tumors has not studied. In...
Previous studies have not clearly identified a prognostic factor for desmoid tumours (DT). Whole-exome sequencing (WES) and/or RNA (RNA-seq) were performed in 64 cases of DT to investigate the molecular profiles combination with clinicopathological characteristics. CTNNB1 mutations specific hotspots 56 (87.5%). A copy number loss chromosome 6 (chr6) was 14 (21.9%). Clustering based on mRNA expression predictive patients' prognoses. The risk score generated by three-gene set (IFI6, LGMN, and...
This retrospective multicenter study aimed to analyze the clinical features and prognosis of 24 patients diagnosed with LGMS between 2002 2019 in Japanese sarcoma network. Twenty-two cases were surgically treated two radical radiotherapy (RT). The pathological margin was R0 14 cases, R1 7 R2 1 case. best overall response who underwent RT one complete partial response. Local relapse occurred 20.8% patients. relapse-free survival (LRFS) 91.3% at 2 years 75.4% 5 years. In univariate analysis,...
Survivin is a member of the inhibitor apoptosis family, which known to inhibit mitochondrial apoptosis. highly expressed in cancers and plays an important role cancer cell survival, increased survivin expression unfavorable prognostic marker patients. YM155, novel small-molecule suppressant, selectively suppresses expression, resulting induction various malignancies. However, roles human malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma (MFH/UPS) have not been studied. In...
Abstract Background Cancer stem cells (CSCs) are considered to be responsible for tumor initiation, formation, and poor prognosis of cancer patients. However, the rarity CSCs in clinical samples makes it difficult elucidate characteristics CSCs, especially osteosarcoma (OS). The aim this study is verify whether possible generate CSC-like by transducing defined factors into an OS cell line. Methods We retrovirally transduced Octamer-binding transcription factor 3/4 ( OCT3/4 ), Kruppel-like 4...
Two cases of deep-seated neurilemmoma that arose from plantar branches the posterior tibial nerve and caused chronic heel pain are described. At initial examination, one case was misdiagnosed as tarsal tunnel syndrome other overlooked fasciitis; both were treated for long periods prior to operation. Deep-seated neurilemmomas in foot can easily be or fasciitis because rarity, absence palpable mass, similarity symptoms those frequently encountered disorders. Magnetic resonance imaging provides...