A5083645230- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Neurofibromatosis and Schwannoma Cases
- Neuroblastoma Research and Treatments
- Oral and Maxillofacial Pathology
- Vascular Tumors and Angiosarcomas
- Management of metastatic bone disease
- Cardiac tumors and thrombi
- Spine and Intervertebral Disc Pathology
- Cancer Mechanisms and Therapy
- Spinal Fractures and Fixation Techniques
- Musculoskeletal synovial abnormalities and treatments
- Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Bone health and treatments
- Orthopedic Infections and Treatments
- Soft tissue tumors and treatment
- Knee injuries and reconstruction techniques
- Lymphoma Diagnosis and Treatment
- Tumors and Oncological Cases
- Polyamine Metabolism and Applications
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- CAR-T cell therapy research
- Infectious Diseases and Tuberculosis
Kyushu University
2014-2024
National Hospital Organization Kyushu Cancer Center
2022-2024
Kyushu Rosai Hospital
2024
Fukushima Medical University
2012-2024
Fukuoka University
2012-2021
National Cancer Center
2015-2017
Experimental Pathology Laboratories
2016
National Cancer Center Hospital East
2014-2015
Tokyo National Hospital
2013
Jichi Medical University
2012
Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue sarcoma with poor prognosis. MPNSTs occur frequently in patients neurofibromatosis type 1 (NF1), which NF1 gene deficiency leads to Ras hyperactivation. activation causes the subsequent of AKT/mTOR and Raf/MEK/ERK pathways regulates cellular functions. However, profiles MAPK are poorly understood. The purposes this study examine correlation between these clinicopathologic or prognostic factors identify candidate target...
Abstract Chondrosarcoma is the second most common malignant bone tumor. It characterized by low vascularity and an abundant extracellular matrix, which confer these tumors resistance to chemotherapy radiotherapy. There are currently no effective treatment options for relapsed or dedifferentiated chondrosarcoma, new targeted therapies need be identified. Isocitrate dehydrogenase (IDH) mutations, detected in ~50% of chondrosarcoma patients, contribute transformation catalyzing production...
Prognosis of osteosarcoma (OS) with distant metastasis and local recurrence is still poor. Y-box binding protein-1 (YB-1) a multifunctional protein that can act as regulator transcription translation its high expression YB-1 was observed in OS, however, the role OS remains unclear. cells inhibited by specific small interfering RNAs to (si-YB-1). The effects si-YB-1 cell proliferation cycle transition were analysed vitro vivo. association nuclear clinical prognosis also investigated...
Myxoid liposarcomas (MLSs) are genetically defined by the presence of DDIT3 gene fusions and most commonly arise in extremities young adults. Whether MLSs develop primarily retroperitoneum is controversial, a recent retrospective study found no molecularly confirmed examples. Because tend to metastasize deep soft tissues, purported examples primary retroperitoneal lesions might represent distant metastasis, from extremities. In addition, well-differentiated or dedifferentiated liposarcomas,...
The Akt/mammalian target of rapamycin (mTOR) pathway mediates cell survival and proliferation contributes to tumor progression. Soft tissue leiomyosarcoma continues show poor prognosis, little is known about its mechanisms Here the authors investigated significance activation Akt/mTOR in soft leiomyosarcomas.The phosphorylation status Akt, mTOR, S6, eukaryotic translation initiation factor 4E-binding protein (4E-BP1) expression phosphatase tensin homologue (PTEN) were assessed by...
p14(ARF), p15(INK4b), and p16(INK4a) are tumor suppressor genes that located closely at 9p21 often coinactivated by genetic or epigenetic alterations. Malignant peripheral nerve sheath (MPNST) is a rare sarcoma with poor prognosis. However, the prognostic implications of inactivation in MPNSTs have not been adequately investigated. Here we carried out genetic, epigenetic, expression analysis p16(INK4a), clarified significance their MPNSTs.p14(ARF), protein expressions were assessed...
Aims Phosphaturic mesenchymal tumour, mixed connective tissue variant (PMT‐MCT), is a tumour of uncertain differentiation, characterised by ‘smudgy/grungy’ calcification and vitamin D‐resistant phosphaturic osteomalacia. Fibroblast growth factor (FGF)23 recognised as reliable marker PMT‐MCT, but quantitative evaluation has never been performed. We reviewed cases tumour‐associated osteomalacia or histologically definitive PMT‐MCT without using histological, immunohistochemical genetic methods...
BACKGROUND The Akt/mammalian target of rapamycin (mTOR) pathway, downstream from phosphatidylinositol 3‐kinase (PI3K), mediates cell survival and proliferation. Although this pathway reportedly contributes to the progression synovial sarcoma, its prognostic impact has not been clarified. METHODS authors analyzed clinicopathologic data phosphorylation status Akt (a serine/threonine kinase also known as protein B), mTOR, eukaryotic translation initiation factor 4E binding (4E‐BP1), S6...
Phosphaturic mesenchymal tumor, mixed connective tissue variant (PMT-MCT) causes tumor-induced osteomalacia (TIO). Most cases follow a benign clinical course, with rare occurrences of malignant transformation. We report case PMT-MCT and review previous to identify predictive factors for A 13-yr-old female, who presented hypophosphatemic rickets, elevated serum intact fibroblast growth factor 23 (FGF23) levels, nodule in the back, received diagnosis TIO because PMT histopathology. After...
Solitary fibrous tumors (SFTs) are soft tissue of intermediate malignancy that rarely metastasize. Although unresectable SFTs reported to have a poor prognosis, the authors' knowledge there is currently no effective therapy. Molecular target therapy promising approach for patients with tumors, but molecular biology insufficient support such The current study investigated activation receptor tyrosine kinases (RTKs) and Akt-mammalian rapamycin (Akt-mTOR) pathway in as therapeutic targets.The...
Abstract Background Tumor-devitalized autografts treated with deep freezing, pasteurization, and irradiation are biological reconstruction methods after tumor excision for aggressive or malignant bone soft tissue tumors that involve a major long bone. do not require bank, they carry no risk of viral bacterial disease transmission, associated smaller immunologic response, have better shape size match to the site in which implanted. However, disadvantages as well; it is possible assess margins...
Background/Aim: Despite the well-publicized clinical outcomes after unplanned excision (UE) and re-excision (re-excision) in patients with soft-tissue sarcoma (STS), there is little information about real-life referral patterns for UE, such as patient profile, details of procedures, subsequent management UE. We aimed to investigate characteristics UE who were referred sarcoma-specific centers. Patients Methods: Between May 2022 June 2023, we registered 97 underwent centers Japan. excluded...
Chronic expanding hematoma is a rare persistent that can sometimes be misdiagnosed as malignant tumor due to its clinical and radiological features. A 42-year-old Japanese man with large mass in his leg, suggestive of malignancy, presented our hospital. He had been aware the leg swelling for last eight years. magnetic resonance imaging scan demonstrated two components. One was large, well-defined cystic (13×9cm) showing high intensity on T1- T2-weighted images, other solid (3.5×2.5cm,...
Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue sarcoma with poor prognosis. Hypoxia-inducible factor 1 (HIF-1) plays crucial role in the cellular response to hypoxia and regulates expression of multiple genes involved progression various cancers. However, importance HIF-1α MPNSTs unclear.The was examined immunohistochemically 82 MPNST specimens. Cell culture assays human cells under normoxic hypoxic conditions were used evaluate impact anti-HIF-1α-specific siRNA...
Tumor prostheses for the lower limb following resection of musculoskeletal tumors is useful salvage management; however, as compared with routine total joint replacement, an increased incidence deep periprosthetic infection tumor prosthesis has been observed. The risk factors remain unclear. This study examines and outcomes infection. was a retrospective observational including 121 patients (67 males 54 females) who underwent after between 1 January 2000 30 November 2018. Among prostheses, 7...
Signal transducer and activator of transcription (STAT) 3 mediates a broad range biological processes, including cell survival proliferation, STAT3 has generally been regarded as pro-oncogenic factor. We investigated the phosphorylation status protein expression suppressor cytokine signaling (SOCS3) by immunohistochemistry in 145 formalin-fixed, paraffin-embedded samples soft tissue leiomyosarcoma (LMS), 129 primary tumors. Eight benign smooth muscle tumors were also examined. Thirteen...