A5071399030- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Oral and Maxillofacial Pathology
- Cancer-related molecular mechanisms research
- Cardiac tumors and thrombi
- Musculoskeletal synovial abnormalities and treatments
- MicroRNA in disease regulation
- Neurofibromatosis and Schwannoma Cases
- Vascular Tumors and Angiosarcomas
- Cancer Genomics and Diagnostics
- Extracellular vesicles in disease
- Tumors and Oncological Cases
- Neuroblastoma Research and Treatments
- Chromatin Remodeling and Cancer
- Orthopedic Infections and Treatments
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- Soft tissue tumor case studies
- Surgical site infection prevention
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Melanoma and MAPK Pathways
- Multiple Myeloma Research and Treatments
Keio University
2016-2025
Keio University Hospital
2019-2024
National Cancer Center Hospital East
2022
National Cancer Centre Japan
2014-2020
National Cancer Center
2013-2020
Kanagawa Prefectural Hospital Organization
2020
Teikyo University Hospital
2020
University of Tokyo Hospital
2020
Chiba Cancer Center
2020
National Cancer Research Institute
2018
Abstract Due to their rarity and diversity, sarcomas are difficult diagnose. Consequently, there is an urgent demand for a novel diagnostic test these cancers. In this study, we investigated serum miRNA profiles from 1002 patients with bone soft tissue tumors representing more than 43 histological subtypes, including sarcomas, intermediate tumors, benign determine whether could be used specifically detect sarcomas. Circulating in sarcoma were clearly distinct those other types of tumors....
<h3>Importance</h3> Epithelioid sarcoma (ES) is an exceedingly rare malignant neoplasm with distinctive pathologic, molecular, and clinical features as well the potential to respond new targeted drugs. Little known on activity of anthracycline-based regimens, gemcitabine-based pazopanib in this disease. <h3>Objective</h3> To report patients advanced ES. <h3>Design, Setting, Participants</h3> Seventeen reference centers Europe, United States, Japan contributed data retrospective analysis...
Abstract The genomic characteristics of dedifferentiated liposarcoma (DDLPS) that are associated with clinical features remain to be identified. Here, we conduct integrated whole exome and RNA sequencing analysis in 115 DDLPS tumors perform comparative well-differentiated components from eight samples. Several somatic copy-number alterations (SCNAs), including the gain 12q15, identified as frequent alterations. CTDSP1/2-DNM3OS fusion genes a subset tumors. Based on association SCNAs...
NTRK fusions in malignant tumors are therapeutic targets of tyrosine kinase inhibitors. Because they occur only a small subset mesenchymal tumors, knowledge regarding the corresponding histology is important to effectively identify patients who could benefit from targeted therapy. In this study, using RNA sequencing, we identified novel NTRK3 involving related partner genes 2 adult bone and soft tissue that met current histologic criteria fibrosarcoma. Case 1 involved left radius 38-year-old...
Aims The diagnosis of a malignant peripheral nerve sheath tumour ( MPNST ) can be challenging, as the morphological criteria and existing immunohistochemical markers are not entirely specific. recent discovery frequent inactivation polycomb repressive complex 2 in s suggests that detection histone 3 trimethylated on lysine 27 (H3K27me3) could diagnostic help. This study aimed to clarify utility this marker. Methods results We performed immunostaining studies, with monoclonal (C36B11)...
Abstract Background Noninvasive detection of early stage cancers with accurate prediction tumor tissue-of-origin could improve patient prognosis. Because miRNA profiles differ between organs, circulating miRNomics represent a promising method for cancers, but this has not been shown conclusively. Methods A serum profile (miRNomes)–based classifier was evaluated its ability to discriminate cancer types using advanced machine learning. The training set comprised 7931 samples from patients 13...
Well-differentiated liposarcoma (WDLPS) and dedifferentiated (DDLPS) are closely related tumors commonly characterized by MDM2/CDK4 gene amplification, lack clinically effective treatment options when inoperable. To identify novel therapeutic targets, we performed targeted genomic sequencing analysis of 19 WDLPS 37 DDLPS tumor samples using a panel 104 cancer-related genes (NCC oncopanel v3) developed specifically for testing to select suitable molecular therapies. The results this indicated...
Epithelioid sarcoma (ES) is an extremely rare soft tissue sarcoma. Recently, the proximal variant has been reported to be a more aggressive subtype; however, as most reports of ES have involved small case series, actual prognostic implications remain unclear. We investigated clinicopathological features patients with identify factors that influence survival.We retrospectively analyzed 44 who had treated at our institutions between 1991 and 2011. Among these patients, 26 were diagnosed...
Adequate bone curettage is crucial for treating epiphyseal chondroblastomas. However, achieving adequate while minimizing damage to the articular cartilage challenging. For lesions at center of distal femoral epiphysis, using an intercondylar approach may have better oncological and functional outcomes than conventional extra‐articular from wall epiphysis. We herein present a case 22‐year‐old male patient with chondroblastoma medial condyle close fossa. Intercondylar was performed site...
Case: Two women (aged 35 and 29 years) with intractable chronic knee infection of tumor prostheses opted for amputation. As only the trochanteric region could be preserved, we resected remaining proximal femur created a 15-cm long stump using unaffected thigh soft tissue to avoid drawbacks ultra–high-thigh amputation conventional hip disarticulation. Both had no contracture, move their voluntarily, ambulated standard transfemoral prosthesis without pelvic belt at 4-year 3-year follow-ups,...
Liposarcoma (LPS) is the most common soft-tissue sarcoma in adults, and well-differentiated liposarcoma (WDLPS) dedifferentiated (DDLPS) are frequent subtypes. These LPSs considered to develop due disturbances adipogenic differentiation of mesenchymal stem cells. However, molecular mechanisms underlying remain unclear. Here, we aimed identify mechanism explore its therapeutic advantages focusing upon their epigenetic alterations, known be important differentiation. First, conducted a...
Abstract Granular cell tumors (GCTs) are rare mesenchymal that exhibit a characteristic morphology and finely granular cytoplasm. The genetic alterations responsible for GCT tumorigenesis had been unknown until recently, when loss‐of‐function mutations of ATP6AP1 ATP6AP2 were described. Thus, we performed whole‐exome sequencing, RNA targeted sequencing 51 samples. From these genomic analyses, identified in genes encoding vacuolar H + ‐ATPase (V‐ATPase) components, including , 33 (65%) GCTs....
Abstract Background Tumor-devitalized autografts treated with deep freezing, pasteurization, and irradiation are biological reconstruction methods after tumor excision for aggressive or malignant bone soft tissue tumors that involve a major long bone. do not require bank, they carry no risk of viral bacterial disease transmission, associated smaller immunologic response, have better shape size match to the site in which implanted. However, disadvantages as well; it is possible assess margins...
Aims Malignant rhabdoid tumours ( MRT s) and epithelioid sarcomas ES are distinctive malignant neoplasms with characteristic clinicopathological features. However, these two tumour types share some phenotypic features, such as epithelioid/rhabdoid cytology, expression of epithelial markers, immunohistochemical loss INI 1. The distinction can be problematic in atypical clinical settings, ancillary diagnostic tools needed. CD 34 is widely cited favouring the diagnosis , but no formal...
Abstract Osteosarcoma (OS) patients with metastasis or recurrent tumors still suffer from poor prognosis. Studies have indicated the efficacy of DNA demethylation therapy for OS, but underlying mechanism is unclear. Here, we aimed to clarify how epigenetic has therapeutic in OS. Treatment four OS cell lines a demethylating agent, 5-aza-2′-deoxycytidine (5-aza-dC) treatment, markedly suppressed their growth, and vivo was further confirmed using two xenografts. Genome-wide methylation analysis...
Although eribulin is used to treat soft tissue sarcomas (STSs), treatment data for rare subtypes are limited. We conducted a post-marketing surveillance study assess safety and efficacy of in STS patients stratified by subtype.Japanese (n = 256) with advanced or metastatic receiving were monitored status, adverse events, diagnostic imaging, clinical outcomes at 3 months 1 year. Interim analysis was performed. Patients will be up 2 years.Interim included 3-month 255), imaging 226), 1-year...
Osteosarcoma (OS) is an aggressive mesenchymal tumor for which no molecularly targeted therapies are available. We have previously identified TRAF2- and NCK-interacting protein kinase (TNIK) as essential factor the transactivation of Wnt signal target genes shown that its inhibition leads to eradication colorectal cancer stem cells. The involvement signaling in pathogenesis OS has been implicated. aim present study was examine potential TNIK a therapeutic OS. RNA interference or...
Sarcoma is a rare cancer with several subtypes; therefore, our understanding of the pathogenesis sarcoma limited, and designing effective treatments difficult. Circulating microRNAs (miRNAs), including exosomal miRNAs, have attracted attention as biomarkers in cancer. However, roles miRNAs exosomes remain unclear. The present analysis tissue serum miRNA expression osteosarcoma, Ewing's dedifferentiated liposarcoma (DDLPS) identified miR‑1246, ‑4532, ‑4454, ‑619‑5p ‑6126 for DDLPS. These were...