A5004109275- Helicobacter pylori-related gastroenterology studies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Gastroesophageal reflux and treatments
- Circular RNAs in diseases
- Gastrointestinal motility and disorders
- Gastric Cancer Management and Outcomes
- Eosinophilic Esophagitis
- Esophageal Cancer Research and Treatment
- Extracellular vesicles in disease
- Gastrointestinal disorders and treatments
- Diet and metabolism studies
- Liver physiology and pathology
- Veterinary medicine and infectious diseases
- Esophageal and GI Pathology
- Cancer Cells and Metastasis
- Molecular Biology Techniques and Applications
- Pancreatic function and diabetes
- Pancreatic and Hepatic Oncology Research
- Clostridium difficile and Clostridium perfringens research
- Mycobacterium research and diagnosis
- Pharmacological Effects of Natural Compounds
- RNA modifications and cancer
- Regulation of Appetite and Obesity
- Organ Transplantation Techniques and Outcomes
Keio University
2016-2025
Nanotherapeutics (United States)
2022-2024
Tokyo Medical University
2020-2023
ORCID
2022
University of California, San Francisco
2020
RELX Group (Netherlands)
2020
National Cancer Center
2019
National Cancer Research Institute
2019
Keio University Hospital
2014-2018
Saiseikai Central Hospital
2013-2014
MicroRNA (miRNA), which are stably present in serum, have been reported to be potentially useful for detecting cancer. In the study, we examined expression profiles of serum miRNA several large cohorts identify novel that can used detect early stage breast We comprehensively evaluated using highly sensitive microarray analysis. A total 1280 samples cancer patients stored National Cancer Center Biobank were used. addition, 2836 obtained from non‐cancer controls, 451 with other types cancers,...
A major obstacle to improving prognoses in ovarian cancer is the lack of effective screening methods for early detection. Circulating microRNAs (miRNAs) have been recognized as promising biomarkers that could lead clinical applications. Here, develop an optimal detection method, we use microarrays obtain comprehensive miRNA profiles from 4046 serum samples, including 428 patients with tumors. diagnostic model based on expression levels ten miRNAs constructed discovery set. Validation...
Bladder cancer is the 9th leading cause of death worldwide. The major problem in bladder primarily high recurrence rate after drug treatment and resection. Although conventional screening methods, such as cystoscopy, urinary cytology ultrasound sonography, have become widely used clinical settings, diagnostic performance these modalities unsatisfactory due to low accuracy or invasiveness. Because circulating micro RNA (miRNA) profiles recently been reported an attractive tool for liquid...
Biliary tract carcinomas (BTCs) are among the most aggressive malignancies and have a poor prognosis. Here, we successfully established organoid lines derived from intrahepatic cholangiocarcinoma, gallbladder cancer, neuroendocrine carcinoma of ampulla Vater. These organoids BTCs were cultured stably for >1 year closely recapitulated histopathology, gene expression, genetic alterations evident in primary tumors. Gene expression profiling revealed that SOX2 could be potential prognostic...
Multiple early gastric cancers (EGCs) may develop in 6-14% of patients even after achieving curative endoscopic submucosal dissection (ESD); however, a useful biomarker for predicting recurrence is not available. The present study investigated whether the expression CD44 variant 9 (CD44v9), functional cancer stem cell marker, primary tissue represents an indicator recurrence.Eighty-eight who underwent ESD EGC from 2008 to 2010 were enrolled and monitored 3 years. levels CD44v9 initial EGCs...
Abstract Background Rikkunshito, a standardized J apanese herbal medicine, is thought to accelerate gastric emptying and relieve dyspepsia, although no large‐scale, randomized, placebo‐controlled trials of rikkunshito have been conducted. This study aimed determine the efficacy safety for treating functional dyspepsia ( FD ). Methods patients received 2.5 g or placebo three times day 8 weeks in this multicenter, placebo‐controlled, parallel‐group trial. The primary end point was proportion...
microRNAs (miRNAs) are small non-coding RNAs that can function as endogenous silencers of target genes and play critical roles in human malignancies. To investigate the molecular pathogenesis gastric mucosa-associated lymphoid tissue (MALT) lymphoma, miRNA expression profile was analyzed. microarray analysis with specimens from MALT lymphomas surrounding non-tumor mucosae revealed a hematopoietic-specific miR-142 an oncogenic miR-155 were overexpressed lymphoma lesions. The levels miR-142-5p...
Abstract Lung cancer, the leading cause of cancer death worldwide, is most frequently detected through imaging tests. In this study, we investigated serum microRNAs (miRNAs) as a possible early screening tool for resectable lung cancer. First, used samples from participants with and without to comprehensively create 2588 miRNAs profiles; next, established diagnostic model based on combined expression levels two (miR-1268b miR-6075) in discovery set (208 patients 208 non-cancer participants)....
Abstract Purpose: The high false-positive rate of prostate-specific antigen (PSA) may lead to unnecessary prostate biopsies. Therefore, the United States Preventive Services Task Force recommends that decisions regarding PSA-based screening cancer should be made with caution in men ages 55–69 years, and ≥70 years not undergo PSA screening. Here, we investigated potential serum miRNAs as an accurate diagnostic method patients suspected cancer. Experimental Design: Serum samples 809 cancer,...
Abstract Due to their rarity and diversity, sarcomas are difficult diagnose. Consequently, there is an urgent demand for a novel diagnostic test these cancers. In this study, we investigated serum miRNA profiles from 1002 patients with bone soft tissue tumors representing more than 43 histological subtypes, including sarcomas, intermediate tumors, benign determine whether could be used specifically detect sarcomas. Circulating in sarcoma were clearly distinct those other types of tumors....
Cancer cell–derived extracellular vesicles (EVs) have unique protein profiles, making them promising targets as disease biomarkers. High-grade serous ovarian carcinoma (HGSOC) is the deadly subtype of epithelial cancer, and we aimed to identify HGSOC-specific membrane proteins. Small EVs (sEVs) medium/large (m/lEVs) from cell lines or patient serum ascites were analyzed by LC-MS/MS, revealing that both EV subtypes had proteomic characteristics. Multivalidation steps identified FRα,...
Abstract Background and Aims: Although clarithromycin (CLR) is one of the most commonly recommended component drugs Helicobacter pylori eradication regimens, prevalence CLR‐resistant H. has been increasing. It well known that CLR resistance associated with point mutations in 23S rRNA, but an active multidrug efflux mechanism may also play a role its drug resistance. At least four gene clusters have identified as pump systems present study was designed to investigate their clinical isolates ....
Hepatocytes are regarded as the only effective cell source for transplantation to treat liver diseases; however, their availability is limited due a donor shortage. Thus, novel must be developed. We recently reported that mature rodent hepatocytes can reprogrammed into progenitor-like cells with repopulative capacity using small molecule inhibitors. Here, we demonstrate hepatic progenitor obtained from human infant same strategy. These cells, named chemically induced progenitors (hCLiPs),...
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer deaths worldwide. The high mortality rate in HCC largely due to difficulty early detection. In this study, improve patient outcomes, serum samples from 345 patients with HCC, 46 chronic hepatitis (CH), 93 liver cirrhosis (LC), and 1,033 healthy individuals were analyzed microRNA (miRNA) microarrays. We investigated diagnostic potential circulating miRNAs developed a detection model including stage. A was constructed based...
<h3>Importance</h3> Patients with late-stage esophageal squamous cell carcinoma (ESCC) have a poor prognosis. Noninvasive screening tests using serum microRNAs (miRNAs) to accurately detect early-stage ESCC are needed improve mortality. <h3>Objective</h3> To establish model miRNAs distinguish patients from noncancer controls. <h3>Design, Setting, and Participants</h3> In this case-control study, miRNA expression profiles of (n = 566) control without cancer 4965) were retrospectively analyzed...
Background and Purpose- Numerous studies have shown that circulating microRNAs (miRNAs) can be used as noninvasive biomarkers of various diseases. This study aimed to identify serum miRNAs predict the risk stroke. Methods- The cases were individuals who had been diagnosed with cerebrovascular disorder by brain imaging. controls no history stroke undergone a medical checkup. Serum miRNA profiling was performed for all participants using microarray analysis. Samples divided into discovery,...
Abstract The clinical manifestations of COVID‐19 vary broadly, ranging from asymptomatic infection to acute respiratory failure and death. But the predictive biomarkers for characterizing variability are still lacking. Since emerging evidence indicates that extracellular vesicles (EVs) RNAs (exRNAs) functionally involved in a number pathological processes, we hypothesize these components may be key determinants and/or predictors severity. To test our hypothesis, collected serum samples 31...
Oxidative stress is a major cause of the gastrointestinal damage under physical or psychological stress. Ghrelin exhibits gastroprotective effects and they are supposed to be derived from antioxidant effects. In gastroduodenal mucosal injury, plasma ghrelin levels increase in response demand for cytoprotection. However, condition Helicobacter pylori-induced gastric severe atrophy, concentration shifted lower levels. diabetic gastroparesis, regulation secretion impaired with vagal nerve...
The GerdQ scoring system may be a useful tool for managing gastro-oesophageal reflux disease. However, has not been fully validated in Asian countries.To validate the Japanese version of and to compare this Carlsson-Dent questionnaire (CDQ) both general hospital-based populations.The questionnaires, including versions CDQ, questions designed collect demographic information, were sent population via web, conventional mail. optimal cutoff score differences characteristics between CDQ...
Abstract Background Functional dyspepsia (FD) is a heterogeneous disease, and categorized into postprandial distress syndrome (PDS) epigastric pain (EPS). However, many FD patients have overlap of both PDS EPS. The present study was designed to examine whether could be based on the presence concomitant gastrointestinal symptoms. Methods A web survey comprised Gastrointestinal Symptom Rating Scale (GSRS), Rome III criteria FD, demographic information sent public participants who no history...
MicroRNAs (miRNAs) are small noncoding RNAs that function as endogenous silencers of target genes and play critical roles during carcinogenesis. The selective cyclooxygenase-2 (COX-2) inhibitor celecoxib has been highlighted a potential drug for treatment gastrointestinal tumors. aim this study was to investigate the role miRNAs in gastric carcinogenesis feasibility new therapeutic approach cancer. miRNA expression profiles were examined 53 tumors including adenomas (atypical epithelia),...