A5101583134- Cancer and Skin Lesions
- Oral and Maxillofacial Pathology
- Ear and Head Tumors
- Salivary Gland Tumors Diagnosis and Treatment
- Hedgehog Signaling Pathway Studies
- Sarcoma Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Lymphoma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Monoclonal and Polyclonal Antibodies Research
- Skin and Cellular Biology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cervical Cancer and HPV Research
- Nail Diseases and Treatments
- Soft tissue tumor case studies
- Medical Imaging and Pathology Studies
- Teratomas and Epidermoid Cysts
- Nonmelanoma Skin Cancer Studies
- Tumors and Oncological Cases
- Cutaneous Melanoma Detection and Management
- Molecular Biology Techniques and Applications
- Autoimmune Bullous Skin Diseases
- Breast Lesions and Carcinomas
- Mindfulness and Compassion Interventions
- Chronic Lymphocytic Leukemia Research
Kumamoto University Hospital
2013-2024
San-ikukai Hospital
2022-2023
Kumamoto University
2003-2022
Kōchi University
2015
Kumamoto City Hospital
2012
Kyushu University
2001
Matsuyama Red Cross Hospital
2001
GTx (United States)
1997
Yamaguchi University
1976
Minor salivary gland tumours showing a predominant papillary-cystic structure are rare, and constitute mixture of various types neoplasm; thus, the histopathological assessment these poses significant diagnostic challenge. We aimed to delineate histological characteristics further mutational aspects with particular focus on sialadenoma papilliferum (SP) intraductal papillary mucinous neoplasm (IPMN).We retrieved 28 minor glands, performed re-evaluation mutation analyses several key...
Sixty-four cases of malignant lymphoma involving the liver were examined. Of these, 20 histologically confirmed to be primary hepatic B-cell lymphoma. Twelve these diffuse large (DLBCL) and eight mucosa-associated lymphoid tissue (MALT) 12 DLBCL, six immunohistologically positive for CD10 and/or Bcl6 (indicating a germinal center phenotype), Bcl2, five CD25. Eight DLBCL (66.7%) two MALT (25%) had serum anti-hepatitis C virus (HCV) antibodies HCV RNA. The incidence infection was significantly...
Aims Phosphaturic mesenchymal tumour, mixed connective tissue variant (PMT‐MCT), is a tumour of uncertain differentiation, characterised by ‘smudgy/grungy’ calcification and vitamin D‐resistant phosphaturic osteomalacia. Fibroblast growth factor (FGF)23 recognised as reliable marker PMT‐MCT, but quantitative evaluation has never been performed. We reviewed cases tumour‐associated osteomalacia or histologically definitive PMT‐MCT without using histological, immunohistochemical genetic methods...
Although epidermoid cysts of the palms and soles have long been assumed to develop following implantation an epidermal fragment as a result penetrating injury, pathogenic mechanism is still controversial, discovery more common aetiological agent awaited. Clinical, histological, immunohistochemical molecular biological studies were performed on 119 palmoplantar location, in order examine role eccrine ducts, human papillomavirus (HPV), pathogenesis this disorder. Characteristic histological...
Abstract Background Widespread use of mammography in breast cancer screening has led to the identification increasing numbers patients with ductal carcinoma situ (DCIS). DCIS an area focal invasion 1 mm or less diameter is defined as microinvasion, DCIS-Mi. Identification biological differences between and DCIS-Mi may aid understanding nature causes progression invasiveness. Methods In this study, using resected tissues, we compared pure (52 cases) (28 regard pathological findings...
Hepatoid adenocarcinoma (HAC) is a rare neoplasm with aberrant hepatocellular differentiation. HAC occurs in extrahepatic organs such as the gastrointestinal tract, testes, ovaries, and lungs frequently produces alpha-fetoprotein. A 69-year-old patient was diagnosed clinically T2aN0M0, stage IB, non-small cell lung carcinoma. Because tumor showed tight adhesion to chest wall, we performed left upper lobectomy, combined resection of 3rd 4th ribs, lymph node dissection. Pathological...
Ectopic adrenocorticotropic hormone (ACTH) production by the pancreatic neuroendocrine tumor (p-NET) is relatively rare, and patients with this show poor prognosis. In study, we present case of a 64-year-old woman who presented ectopic ACTH syndrome due to p-NET multiple liver metastases. Computed tomography revealed that she had masses in solid mass head pancreas. Endocrinological examinations markedly elevated plasma (735.0 pg/mL) cortisol (34.7 μg/dL) levels associated hypokalemia (2.7...
Background We recently proposed that certain palmoplantar epidermoid cysts may be related to eccrine ducts and human papillomavirus (HPV) 60 play a role in their pathomechanism. However, the origin of is still controversial. Objectives To examine contribution HPV development cysts. Methods Five four ridged warts had developed on soles patient were studied histologically, immunohistochemically by DNA–DNA situ hybridization. Using serial sections obtained from its entire body,...
We report a case of microsecretory adenocarcinoma the hard palate. The patient is 37‐year‐old woman with 15 mm submucosal tumor, which was incidentally found by her primary care dentist, in Preoperative magnetic resonance imaging revealed tumor exhibiting high signal on T2‐weighted image, gradually enhanced dynamic study. Histologically, border ill‐defined without fibrous capsule and adjoined minor salivary gland permeative infiltration at periphery. comprised intercalated duct‐like cells...
Presented herein is the first case of malignant adenomyoepithelioma (malignant AME) breast combined with invasive lobular carcinoma (ILC) in a 53-year-old woman. Histologically, tumor was composed nodular proliferation biphasic epithelial and myoepithelial carcinoma, partially surrounded by ILC. Interestingly, ILC metastasized to axillary lymph nodes, while hematogenously lung kidney. On immunohistochemistry consisted cytokeratin (CK) 8/18-positive/CK5/6-positive/smooth muscle actin...
An 83-year-old Japanese man presented with multiple verrucous papules clustering on a plaque located the frontal aspect of scrotum. Histologically, there were three distinct epithelial changes compatible condyloma acuminatum, Bowen's disease, and extramammary Paget's disease (EMPD). By in situ hybridization, zone acuminatum was positive for HPV 6 well demarcated from 31-positive disease. EMPD negative targeted 6/11/16/18/31/33 probes. Immunohistochemically, cells expressing cytokeratin 7...
Presented herein is the second case of sialadenoma papilliferum bronchus in a 75‐year‐old man. The bronchial tumor had an exophytic papillary lesion protruding into lumen ostial region right superior lobe on chest CT and bronchoscopy. Grossly, resected was pedunculated, 5 × 3 mm size consisted both glandular component submucosa. Histologically, structures were lined by ciliated or non‐ciliated columnar epithelium metaplastic non‐keratinizing stratified squamous epithelium. submucosal...
Sialadenoma papilliferum (SP) is a rare benign tumor of the salivary glands, and only 3 unequivocal cases SP arising in bronchus have been reported. We herein describe histomorphologic molecular features 4 bronchial discuss differential diagnosis this entity relationship with its clinicopathologic mimics, particular, glandular papilloma mixed squamous cell (GP/MP). encountered 2 male female patients (mean: 66.8 y old). All tumors arose central were characterized by combination surface...