A5103038675- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Knee injuries and reconstruction techniques
- Orthopedic Infections and Treatments
- Sarcoma Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Hip disorders and treatments
- Lower Extremity Biomechanics and Pathologies
- Bone Tumor Diagnosis and Treatments
- Spinal Fractures and Fixation Techniques
- Osteoarthritis Treatment and Mechanisms
- Bone and Joint Diseases
- Musculoskeletal synovial abnormalities and treatments
- Rheumatoid Arthritis Research and Therapies
- Orthopedic Surgery and Rehabilitation
- Shoulder Injury and Treatment
- Bone Tissue Engineering Materials
- Musculoskeletal pain and rehabilitation
- Scoliosis diagnosis and treatment
- Pelvic and Acetabular Injuries
- Elbow and Forearm Trauma Treatment
- Nerve injury and regeneration
- Oral and Maxillofacial Pathology
- Nerve Injury and Rehabilitation
- Bone fractures and treatments
Kyoto University
2016-2025
Kyoto University Hospital
2016-2025
Neurology, Inc
2025
Ito Hospital
2024
Osaka University of Pharmaceutical Sciences
2023-2024
Kindai University
2024
RELX Group (United States)
2024
The University of Tokyo
2009-2023
NTT Medical Center
2017-2023
Mitsubishi Electric (Japan)
1989-2023
The histology and mechanics of leg lengthening by callus distraction were studied in 27 growing rabbits. Tibial diaphyses subjected to subperiosteal osteotomy, held a neutral position for 10 days then slowly distracted at 0.25 mm/12 hours, using dynamic external fixator. Radiographs showed that the gap became filled with having three distinct zones. Elongation appeared occur central radiolucent zone; this was bounded two sclerotic Histologically, zone consisted longitudinally arranged...
Patient satisfaction has increasingly been recognized as an important measure after total knee arthroplasty (TKA). However, we do not know yet how and why the patients are satisfied or dissatisfied with TKA.We asked: (1) After TKA, which activities were they able to do? (2) Are patient-derived scores related physician-derived scores? (3) Which factors affect patient function?We retrospectively evaluated 375 who had undergone 500 TKAs between February 22, 2000 December 1, 2009. We sent a...
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized by extraskeletal bone formation through endochondral ossification. FOP patients harbor point mutations in ACVR1 (also known as ALK2), type I receptor for morphogenetic protein (BMP). Two mechanisms of mutated (FOP-ACVR1) have been proposed: ligand-independent constitutive activity and ligand-dependent hyperactivity BMP signaling. Here, using patient-derived induced pluripotent stem cells (FOP-iPSCs), we...
Prospective consecutive clinical study to assess the decompressive benefit and outcome of oblique lateral interbody fusion for lumbar degenerative diseases.To evaluate radiologically effect distraction upon neural patency via an anterolateral retroperitoneal approach treatment diseases.Traditional symptomatic stenosis uses direct posterior decompression with or without fusion. Symptoms radiculopathy neurological claudication may also be alleviated indirectly through restoration...
Highlights•We established hiPSCs that express EGFP in chondrocytes when differentiated•We developed a method for generating scaffoldless hyaline cartilage from hiPSCs•The hiPSC-derived neocartilage integrated into adjacent native articular cartilage•The produced neither tumors nor ectopic tissue vivoSummaryDefects ultimately result loss of joint function. Repairing defects requires cell sources. We an approach to generate human induced pluripotent stem cells (hiPSCs). initially generated...
Abstract Induced pluripotent stem cells (iPSCs) are a promising resource for allogeneic cartilage transplantation to treat articular defects that do not heal spontaneously and often progress debilitating conditions, such as osteoarthritis. However, the best of our knowledge, into primate models has never been assessed. Here, we show iPSC-derived organoids survive integrate well remodeled in model chondral knee joints. Histological analysis revealed elicited no immune reaction directly...
ABSTRACT While it is well known that Staphylococcus aureus establishes chronic implant‐associated osteomyelitis by generating and persisting in biofilm, research to elucidate pathogen, host specific factors controlling this process has been limited due the absence of a quantitative vivo model. To address this, we developed murine tibia implant model with ex region interest (ROI) imaging analysis scanning electron microscopy (SEM). Implants were coated strains (SH1000, UAMS‐1, USA300LAC)...
MicroRNAs (miRNAs) are present in human plasma and known as a non-invasive biomarker for cancer detection. Our study was designed to identify miRNAs specific rheumatoid arthritis (RA) by comprehensive array approach. We performed systematic, array-based miRNA analysis on samples from three RA patients healthy controls (HCs). Plasma with more than four times change or significant (P<0.05) expression, detectable only plasma, were confirmed eight HCs using real-time quantitative PCR....
Patients with developmental dysplasia of the hip are prone to development degenerative changes in affected hip. The aim this study was evaluate prevalence, morphological features, and clinical relevance acetabular retroversion these patients.We investigated version features acetabulum using pelvic radiographs computed tomography images ninety-six hips fifty-nine patients A diagnosis based on presence a positive cross-over sign radiograph. Using images, we determined anteversion angle at...
Rationale: The management of macrolide-resistant Mycobacterium avium complex (MR-MAC) pulmonary disease is difficult and thought to be analogous that multidrug-resistant tuberculosis (MDR-TB).Objectives: This study aimed clarify the cause MR-MAC, see how its affected outcome, compare prognosis with MDR-TB.Methods: medical records 102 consecutive cases MR-MAC at three tertiary hospitals for mycobacteriosis in metropolitan Tokyo one Aichi prefecture from 2005 2014 were reviewed. data 311...
Although autologous nerve grafting is the gold standard treatment of peripheral injuries, several alternative methods have been developed, including conduits that use supportive cells. However, seeding efficacy and viability cells injected in grafts remain unclear. Here, we focused on a novel completely biological, tissue-engineered, scaffold-free conduit.We developed six from human normal dermal fibroblasts using Bio 3D Printer. Twelve adult male rats with immune deficiency underwent...
MicroRNAs (miRNAs) are endogenous small noncoding RNAs that regulate the activity of target messenger (mRNAs) and cellular processes. MicroRNA-451 (miR-451) is one miRNAs conserved perfectly among vertebrates, it regulates cell proliferation, invasion, apoptosis in tumors. However, role miR-451 autoimmune arthritis unknown. This study was undertaken to identify arthritis.We compared expression neutrophils from patients with rheumatoid (RA) healthy controls. We also evaluated neutrophil...
ABSTRACT MicroRNAs (miRNAs) are endogenous small noncoding RNAs regulating the activities of target mRNAs and cellular processes. Although no miRNA has been reported to play an important role in regulation fracture healing, several miRNAs control key elements tissue repair processes such as inflammation, hypoxia response, angiogenesis, stem cell differentiation, osteogenesis, chondrogenesis. We compared plasma concentrations 134 4 patients with trochanteric fractures healthy controls (HCs),...
Objective Hypoxia occurs in tumors, infections, and sites of inflammation, such as the affected joints patients with rheumatoid arthritis (RA). It alleviates inflammatory responses increases bone resorption by enhancing osteoclastogenesis. The mechanism which hypoxia response is linked to osteoclastogenesis unclear. This study was undertaken evaluate whether protein lysine‐specific demethylase 1 (LSD1) metabolically integrates a state arthritis. Methods LSD1‐specific inhibitors gene...
Patients with Alzheimer's disease (AD) are known to exhibit visuospatial processing impairment, as reflected in eye movements from the early stages of disease. We investigated whether pattern gaze exploration during visual tasks could be useful for detecting cognitive decline at earliest stage.Sixteen AD patients (age: 79.1 ± 7.9 years, Mini Mental State Examination [MMSE] score: 17.7 5.3, mean standard deviation) and 16 control subjects 79.4 4.6, MMSE 26.9 2.4) participated. In memory task,...