A5039685784- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Vasculitis and related conditions
- T-cell and B-cell Immunology
- Lymphoma Diagnosis and Treatment
- Biosimilars and Bioanalytical Methods
- Systemic Sclerosis and Related Diseases
- Atherosclerosis and Cardiovascular Diseases
- Musculoskeletal synovial abnormalities and treatments
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Eosinophilic Disorders and Syndromes
- Immunodeficiency and Autoimmune Disorders
- Immunotherapy and Immune Responses
- Spondyloarthritis Studies and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Cell Adhesion Molecules Research
- Bone and Joint Diseases
- Viral Infections and Immunology Research
- Hepatitis C virus research
- Peripheral Neuropathies and Disorders
- Nutrition and Health in Aging
Osaka Metropolitan University
2022-2025
Tokyo Metropolitan University
2023-2025
Osaka City University
2000-2024
Kyoto University
2015-2024
Memorial Hospital
2024
Metropolitan University
2023
Takao Hospital
2020
Institute for Rheumatic Diseases (Japan)
2020
Kyoto University of Education
2020
Ijinkai Takeda General Hospital
2020
This report shows that interleukin (IL) 17–producing T helper type 17 (Th17) cells predominantly express CC chemokine receptor (CCR) 6 in an animal model of rheumatoid arthritis (RA). Th17 induced vivo normal mice via homeostatic proliferation similarly CCR6, whereas those inducible vitro by transforming growth factor β and IL-6 additionally need IL-1 neutralization interferon (IFN) γ IL-4 for CCR6 expression. Forced expression RORγt, a key transcription cell differentiation, induces not...
This report shows that highly self-reactive T cells produced in mice as a result of genetically altered thymic cell selection spontaneously differentiate into interleukin (IL)-17–secreting CD4+ helper (Th) (Th17 cells), which mediate an autoimmune arthritis clinically and immunologically resembles rheumatoid (RA). The thymus-produced cells, become activated the periphery via recognition major histocompatibility complex/self-peptide complexes, stimulate antigen-presenting (APCs) to secrete...
Objective Interstitial lung disease ( ILD ) accompanied by anti–melanoma differentiation–associated gene 5 (anti– MDA ‐5)–positive dermatomyositis DM is often rapidly progressive and associated with poor prognosis. Because there no established treatment, we undertook this study to prospectively evaluate the efficacy safety of a combined immunosuppressive regimen for anti– ‐5–positive patients . Methods Adult Japanese new‐onset (n = 29) were enrolled at multiple centers from 2014 2017. They...
Abstract Small, soluble metabolites not only are essential intermediates in intracellular biochemical processes, but can also influence neighbouring cells when released into the extracellular milieu 1–3 . Here we identify metabolite and neurotransmitter GABA as a candidate signalling molecule synthesized secreted by activated B plasma cells. We show that cell-derived promotes monocyte differentiation anti-inflammatory macrophages secrete interleukin-10 inhibit CD8 + T cell killer function....
Activation of serum complement triggers Th17 cell–dependent spontaneous autoimmune disease in an animal model. In genetically autoimmune-prone SKG mice, administration mannan or β-glucan, both which activate complement, evoked cell–mediated chronic arthritis. C5a, a chief component activation produced via all three pathways (i.e., lectin, classical, and alternative), stimulated tissue-resident macrophages, but not dendritic cells, to produce inflammatory cytokines including IL-6, synergy...
MicroRNAs (miRNAs) are present in human plasma and known as a non-invasive biomarker for cancer detection. Our study was designed to identify miRNAs specific rheumatoid arthritis (RA) by comprehensive array approach. We performed systematic, array-based miRNA analysis on samples from three RA patients healthy controls (HCs). Plasma with more than four times change or significant (P<0.05) expression, detectable only plasma, were confirmed eight HCs using real-time quantitative PCR....
Abstract Objective Although interleukin‐17 (IL‐17)–producing γ/δ T cells were reported to play pathogenic roles in collagen‐induced arthritis (CIA), their characteristics remain unknown. The aim of this study was clarify whether or CD4+ are the predominant IL‐17–producing cells, and determine what stimulates secret IL‐17 mice with CIA. involvement SKG autoimmune patients rheumatoid (RA) also investigated. Methods affected joints CIA counted by intracellular cytokine staining during 6...
Objectives: Sarcopenia is characterized by loss of muscle strength and mass, leading to falls adverse health outcomes. Our aim was determine the prevalence sarcopenia in patients with rheumatoid arthritis (RA) identify factors associated these patients. Methods: A cross-sectional study 388 consecutive women RA conducted, assessing mass strength, walking speed. Falls bone fractures sustained over prior year were evaluated. The association between characteristics, falls, evaluated using...
Rapidly progressive interstitial lung disease (RP-ILD) with poor prognosis often accompanies anti-melanoma differentiation-associated gene 5 (MDA5)-positive DM. Combined immunosuppressive therapy, including glucocorticoids, calcineurin inhibitors and intravenous cyclophosphamide (IVCY) is reportedly effective in DM RP-ILD, but some patients remain resistant to therapy. We examined the utility of plasma exchange (PE) such intractable cases investigated prognostic factors disease.Thirty-eight...
The purpose of this study was to evaluate the retention and discontinuation reasons seven biological disease-modifying antirheumatic drugs (bDMARDs) in a real-world setting patients with rheumatoid arthritis (RA). 1,037 treatment courses bDMARDs from 2009 2016 [female, 81.8%; baseline age, 59.6 y; disease duration 7.8 factor positivity 81.5%; Disease Activity Score 28 joints using erythrocyte sedimentation rate (DAS28-ESR), 4.4; concomitant prednisolone 43.5% methotrexate 68.6%; Bio-naïve,...
Objective Hypoxia occurs in tumors, infections, and sites of inflammation, such as the affected joints patients with rheumatoid arthritis (RA). It alleviates inflammatory responses increases bone resorption by enhancing osteoclastogenesis. The mechanism which hypoxia response is linked to osteoclastogenesis unclear. This study was undertaken evaluate whether protein lysine‐specific demethylase 1 (LSD1) metabolically integrates a state arthritis. Methods LSD1‐specific inhibitors gene...
Mice with a mutation of the zeta-associated protein 70 kDa gene (skg mutation) are genetically prone to develop autoimmune arthritis, depending on environment. In set mice mutation, amount as well its tyrosine phosphorylation upon TCR stimulation decreased from +/+, skg/+, skg/skg, skg/- in stepwise manner. The reduction resulted graded alterations thymic positive and negative selection self-reactive T cells Foxp3(+) natural regulatory (Tregs) their respective functions. Consequently,...
T cells that mediate autoimmune diseases such as rheumatoid arthritis (RA) are difficult to characterize because they likely be deleted or inactivated in the thymus if self antigens recognize ubiquitously expressed. One way obtain and analyze these is alter cell receptor (TCR) signaling developing change their sensitivity thymic negative selection, thereby allowing production. From mice thus engineered generate mediating arthritis, we isolated arthritogenic TCRs characterized recognized. of...
Abstract Aim Age at disease onset has been implicated as an indicator of activity and severity in rheumatoid arthritis (RA). This study aimed to investigate how old age affects patient treatment prognosis early RA. Methods Data from the Kyoto University Rheumatoid Arthritis Management Alliance (KURAMA) cohort was analyzed. From 2011 2015, a total 2182 patients with RA were enrolled cohort; 239 newly diagnosed followed up for 2 years. The divided into following two groups: young‐onset (YORA)...
Background The aim of this study is to evaluate the retention rates and reasons for discontinuation seven biological disease-modifying antirheumatic drugs (bDMARDs) in a real-world setting elderly patients (65 years age or older) with rheumatoid arthritis (RA). Methods This multi-center, retrospective assessed 1,098 treatment courses 661 bDMARDs from 2009 2018 (females, 80.7%; baseline age, 71.7 years; disease duration 10.5 factor positivity 81.3%; Disease Activity Score 28 joints using...
Difficult-to-treat rheumatoid arthritis (D2T RA) is a multifactorial condition in which disease activity of RA persists despite consecutive treatment with biological or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs). To evaluate the prevalence and predictive risk factors D2T our institution, single-center, retrospective study was conducted. Medical records patients, who visited hospital from 2011 to 2020 had follow-up more than 6 months, were retrospectively reviewed....
Abstract This multi-center, retrospective study aimed to clarify the factors affecting drug retention of Janus kinase inhibitors (JAKi) including baricitinib (BAR) and tofacitinib (TOF) in patients with RA. Patients were as follows; females, 80.6%; age, 60.5 years; DAS28-ESR, 4.3; treated either BAR (n = 166) or TOF 185); bDMARDs- JAKi-switched cases (76.6%). The reasons for discontinuation classified into four major categories. was evaluated at 24 months using Kaplan–Meier method...
Abstract Background Advances in rheumatoid arthritis (RA) treatment, highlighted by biological disease-modifying antirheumatic drugs (bDMARDs) and targeted synthetic DMARDs (tsDMARDs), have altered the paradigm of RA treatment last decade. Therefore, real-world clinical evidence is needed to understand how strategies outcomes changed. Methods Using an observational cohort from 2012 2021, we collected cross-sectional data patients annually analyze a trend management. For who initiated...
Abstract Objectives This multicentre retrospective study aimed to evaluate differences in drug continuation rates and efficacy between first- second-line use of biological disease-modifying antirheumatic drugs (bDMARDs) Janus kinase inhibitors (JAKi) after failure the initial therapy real-world rheumatoid arthritis (RA) settings. Methods Data from an observational registry patients with RA Japan were analysed, encompassing 5,900 treatment courses (4,046 bDMARD/JAKi-naïve cases 1,854 s-line...
Objective Th17 has been shown to have a pivotal role in the development of arthritis. However, IL-17 T cell-independent effector phase not fully examined. We investigated whether is involved arthritis by using K/BxN serum-induced model. Methods serum was transferred into knockout (KO) mice, SCID mice and their control evaluated over time. In order clarify source phase, neutrophils or CD4+ cells collected from KO were injected recipient together with serum. To examine if secrete upon...