A5101484324- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Earthquake and Tsunami Effects
- Antifungal resistance and susceptibility
- Wave and Wind Energy Systems
- Immunodeficiency and Autoimmune Disorders
- Philosophy, Science, and History
- Coastal and Marine Dynamics
- Fungal Infections and Studies
- Religious Education and Schools
- Critical Theory and Philosophy
Kyoto University
2003-2022
Frontier Medical College
2010
Sapporo City General Hospital
2005
Heidelberg University
2005
German Cancer Research Center
2005
This report shows that highly self-reactive T cells produced in mice as a result of genetically altered thymic cell selection spontaneously differentiate into interleukin (IL)-17–secreting CD4+ helper (Th) (Th17 cells), which mediate an autoimmune arthritis clinically and immunologically resembles rheumatoid (RA). The thymus-produced cells, become activated the periphery via recognition major histocompatibility complex/self-peptide complexes, stimulate antigen-presenting (APCs) to secrete...
A combination of genetic and environmental factors can cause autoimmune disease in animals. SKG mice, which are genetically prone to develop arthritis, fail the under a microbially clean condition, despite active thymic production arthritogenic T cells their persistence periphery. However, environment, single intraperitoneal injection zymosan, crude fungal beta-glucan, or purified beta-glucans such as curdlan laminarin trigger severe chronic arthritis but only transient normal mice. Blockade...
Mice with a mutation of the zeta-associated protein 70 kDa gene (skg mutation) are genetically prone to develop autoimmune arthritis, depending on environment. In set mice mutation, amount as well its tyrosine phosphorylation upon TCR stimulation decreased from +/+, skg/+, skg/skg, skg/- in stepwise manner. The reduction resulted graded alterations thymic positive and negative selection self-reactive T cells Foxp3(+) natural regulatory (Tregs) their respective functions. Consequently,...
Thymic selection and peripheral activation of conventional T (Tconv) regulatory (Treg) cells depend on TCR signaling, whose anomalies are causative autoimmunity. Here, we expressed in normal mice mutated ZAP-70 molecules with different affinities for the CD3 chains, or wild type at graded expression levels under tetracycline-inducible control. Both manipulations reduced signaling intensity to various extents thereby rendered those normally deleted self-reactive thymocytes become positively...
階段式護岸のステップ高は通常0.2～0.3m程度に設定されている．しかしながら，こうした緩勾配階段式護岸の勾配は人の歩行を考えて1/2～1/3程度に取られるため，占有面積が大きくなることや波の遡上高が高くなるなどの問題点を抱えている．階段式護岸設置の主な理由は，人の海岸利用や景観への配慮など親水性向上にある．したがって，実務設計者は，波の遡上高や反射率など防災上必要となる数値的な把握のみでなく，実際に護岸上で繰り広げられる砕波現象，流れや渦の発生など，水理学的特性の把握も求められる．本研究は，CADMAS-SURFを用いた数値計算によって，代表例としてステップの高さが0.2mと1.4mの場合の波の遡上高及び反射率の特性を対象に，波の砕波形態，ステップ上での流れや渦の発生など水理学的な特性との関連を明らかにしている．