A5041701717- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Sarcoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Pleural and Pulmonary Diseases
- Medical Imaging and Pathology Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Bone Tumor Diagnosis and Treatments
- Tracheal and airway disorders
- Metastasis and carcinoma case studies
- Oral and Maxillofacial Pathology
- Esophageal Cancer Research and Treatment
- Immunotherapy and Immune Responses
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Anesthesia and Pain Management
- Nausea and vomiting management
- Congenital Diaphragmatic Hernia Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
Katsushika Medical Center
2025
Aichi Cancer Center
2019-2024
Osaka University
2014-2024
Akita University Hospital
2022-2024
Jikei University School of Medicine
2023-2024
Wake Forest University
2024
Hokkaido University
2016-2024
Tokyo-Kita Medical Center
2023-2024
Shimane University
2008-2023
Kyoto University
2012-2023
Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue sarcoma with poor prognosis. MPNSTs occur frequently in patients neurofibromatosis type 1 (NF1), which NF1 gene deficiency leads to Ras hyperactivation. activation causes the subsequent of AKT/mTOR and Raf/MEK/ERK pathways regulates cellular functions. However, profiles MAPK are poorly understood. The purposes this study examine correlation between these clinicopathologic or prognostic factors identify candidate target...
This phase III, multicenter, randomized, open-label study investigated the efficacy and safety of nivolumab versus chemotherapy (gemcitabine [GEM] or pegylated liposomal doxorubicin [PLD]) in patients with platinum-resistant ovarian cancer.
Background A better understanding of the tumor immune microenvironment (TIME) will facilitate development prognostic biomarkers and more effective therapeutic strategies in patients with lung cancer. However, little has been reported on comprehensive evaluation complex interactions among cancer cells, local immunosuppressive elements TIME. Methods Whole-exome sequencing RNA were carried out 113 cancers. We performed single sample gene set enrichment analysis TIME-related sets to develop a...
Here, we examined phytoestrogens, isoflavones (genistein, daidzein, glycitein, biochanin A and ipriflavone), flavones (chrysin, luteolin apigenin), flavonols (kaempferol quercetin), a coumestan, flavanone chalcone (coumestrol, naringenin phloretin, respectively) by means of DNA microarray assay. total 172 estrogen responsive genes were monitored with customized their expression profiles for the above phytoestrogens compared that 17β‐estradiol (E 2 ) using correlation coefficients, or R...
Diverse functions of microRNAs (miRNAs), including effects on tumorigenesis, proliferation, and differentiation, have been reported, several miRNAs also demonstrated to play an important role in apoptosis. In this study, we investigated the possible that may development chemoresistance Ewing sarcoma/primitive neuroectodermal tumor (EWS).We screened doxorubicin (Dox)-resistant EWS cells identify any distinct miRNA sequences regulate cells. The were evaluated using a chemosensitivity assay....
A precise preoperative diagnosis of 'very early' lung carcinoma may identify patients who can undergo curative surgery with limited resections.Data from a multi-institutional project were collected on 1737 had undergone resections (segmentectomy or wedge resection) for T1N0M0 non-small-cell carcinomas. As it was expected, this study predominantly including ground glass nodules. Computed tomography used to obtain the ratio consolidation maximal tumour diameter determine invasive potential...
In many countries, gastric cancer is not diagnosed until an advanced stage. An Internet-based e-learning system to improve the ability of endoscopists diagnose at early stage was developed and evaluated for its effectiveness.The study designed as a randomized controlled trial. After receiving pre-test, participants were randomly allocated either or non-e-learning group. Only those in group gained access system. Two months after both groups received post-test. The primary endpoint difference...
The association between the presence of sarcopenia and systemic inflammatory response is unclear in patients with esophageal cancer. This study was performed to investigate relationship clarify effect these factors on prognosis cancer.This included 163 patients' body composition assessed before esophagectomy using multifrequency bioelectrical impedance. were investigated surgery.Sarcopenia significantly associated a high C-reactive protein-to-albumin (CRP/Alb) ratio (p=0.046). Patients worse...
The nitric oxide synthase (NOS) gene is thought to be associated with essential hypertension (EH), because NO implicated in endothelium‐mediated vasodilation. We investigated the possible association between alleles of simple tandem repeat DNA polymorphism endothelial constitutive NOS (cNOS) and EH Japanese subjects. In all, 100 patients 123 subjects normal blood pressure were studied. Polymerase chain reaction was used amplify CA site cNOS based on number determined. allele frequencies...
p14(ARF), p15(INK4b), and p16(INK4a) are tumor suppressor genes that located closely at 9p21 often coinactivated by genetic or epigenetic alterations. Malignant peripheral nerve sheath (MPNST) is a rare sarcoma with poor prognosis. However, the prognostic implications of inactivation in MPNSTs have not been adequately investigated. Here we carried out genetic, epigenetic, expression analysis p16(INK4a), clarified significance their MPNSTs.p14(ARF), protein expressions were assessed...
Early detection of non-small-cell lung cancer (NSCLC) and accurate prognostic risk assessment could improve patient outcome. We examined the significance urinary N1, N12-diacetylspermine (DiAcSpm) in stratification NSCLC patients. A DiAcSpm/cutoff ratio (DASr) was established for 260 patients, 99 benign disease 140 healthy volunteers, using colloidal gold aggregation methods. The DASr compared between patients controls, examined. median significantly higher than that controls (0.810 vs...
Programmed death-ligand 1 (PD-L1) expression is a predictor of immune checkpoint inhibitor (ICI) treatment efficacy. The clinical efficacy ICIs for non-small-cell lung cancer (NSCLC) patients harboring major mutations, such as EGFR or ALK limited. We genotyped 190 with advanced adenocarcinomas who received nivolumab pembrolizumab monotherapy, and examined the in NSCLC without mutations. Among enrolled genotyping study, 47 harbored 25 had KRAS 5 HER2 mutation, 6 BRAF 7 rearrangement. status...
Background and Objectives: Panel-based next-generation sequencing (NGS) has been carried out in daily clinical settings for the diagnosis treatment guidance of patients with non-small cell lung cancer (NSCLC). The success genomic tests including NGS depends large part on preparing better-quality DNA or RNA; however, there are no established operating methods RNA samples. Materials Methods: We compared following two quantitative methods, QubitTM NanoDropTM, using 585 surgical specimens, 278...
CD8+tumor infiltrating lymphocytes (TILs) are often observed in non-small cell lung cancers (NSCLC). However, the characteristics of CD8+ TILs, especially T-cell populations specific for tumor antigens, remain poorly understood. High throughput single-cell RNA sequencing and receptor (TCR) were performed on TILs from three surgically-resected cancer specimens. Dimensional reduction clustering was using Uniform Manifold Approximation Projection. TIL TCR cancer/testis antigen KK-LC-1 predicted...