A5066674610- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Tracheal and airway disorders
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Medical Imaging and Pathology Studies
- Congenital Diaphragmatic Hernia Studies
- Myasthenia Gravis and Thymoma
- Cancer Immunotherapy and Biomarkers
- Management of metastatic bone disease
- Transplantation: Methods and Outcomes
- Neurofibromatosis and Schwannoma Cases
- Nutrition and Health in Aging
- Sarcoma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Anatomy and Medical Technology
- Salivary Gland Tumors Diagnosis and Treatment
- Surgical Simulation and Training
- Airway Management and Intubation Techniques
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Research Studies
- Vitamin D Research Studies
- Neuroblastoma Research and Treatments
Jikei University School of Medicine
2015-2025
Aichi Cancer Center
2019-2024
The Jikei University Hospital
2024
Peking University First Hospital
2023
Peking University
2021-2023
Jikei University Kashiwa hospital
2013-2022
Hainan Medical College Hospital
2021
Peking University Cancer Hospital
2021
State Key Laboratory of Respiratory Disease
2021
Guangzhou Medical University
2021
Abstract Purpose: Higher serum 25-hydroxyvitamin D (25(OH)D) levels are reportedly associated with better survival in early-stage non–small cell lung cancer (NSCLC). Therefore, whether vitamin supplementation can improve the prognosis of patients NSCLC was examined (UMIN000001869). Patients and Methods: A randomized, double-blind trial comparing supplements (1,200 IU/day) placebo for 1 year after operation conducted. The primary secondary outcomes were relapse-free (RFS) overall (OS),...
Background A better understanding of the tumor immune microenvironment (TIME) will facilitate development prognostic biomarkers and more effective therapeutic strategies in patients with lung cancer. However, little has been reported on comprehensive evaluation complex interactions among cancer cells, local immunosuppressive elements TIME. Methods Whole-exome sequencing RNA were carried out 113 cancers. We performed single sample gene set enrichment analysis TIME-related sets to develop a...
We investigated the relationship of lymph node metastasis to primary tumor size and microscopic appearance in 92 resected specimens obtained from patients with roentgenographically occult lung cancer (ROLC) located at a site along airway between main bronchus sub-subsegmental bronchi. Most were discovered by mass screening. All treated surgically after bronchoscopic localization cancer. The bronchial tree was serial-sectioned into 2-mm thick blocks margin resection Bronchial wall invasion...
Lung surgeries in patients with bronchial variations have rarely been reported. Here, we describe the case of a patient along lung cancer variant anatomy right upper lobe bronchus. This variation was evaluated by three-dimensional multi-detector computed tomography angiography bronchography and printing model using rapid prototyping. The anterior segment bronchus (S3) arising from middle confirmed before surgery model, which helped to determine extent resection required facilitated...
Thoracoscopic segmentectomies and subsegmentectomies are more difficult than lobectomy because of the complexity procedure; therefore, preoperative decision-making surgical procedure planning essential. In literature, we could successfully perform thoracoscopic anatomical subsegmentectomy right S2b + S3 using a 3D printing model with rapid prototyping. This innovative support is extremely useful for identifying margin.
Programmed death-ligand 1 (PD-L1) expression is a predictor of immune checkpoint inhibitor (ICI) treatment efficacy. The clinical efficacy ICIs for non-small-cell lung cancer (NSCLC) patients harboring major mutations, such as EGFR or ALK limited. We genotyped 190 with advanced adenocarcinomas who received nivolumab pembrolizumab monotherapy, and examined the in NSCLC without mutations. Among enrolled genotyping study, 47 harbored 25 had KRAS 5 HER2 mutation, 6 BRAF 7 rearrangement. status...
Minimally invasive thoracoscopic lobectomy is the recommended surgery for clinical stage I non-small cell lung cancer (NSCLC). The purpose of this study was to identify risk factors, including sarcopenia, postoperative complications in patients undergoing a complete single-lobe NSCLC, as well impact on disease-free survival.We retrospectively investigated 173 with pathologically-diagnosed NSCLC who underwent curative lobectomies between April 2013 and March 2018. Sarcopenia assessed using...
Airway stenting is frequently used in the palliative treatment of patients with advanced tumor-induced airway stenosis and fistulas. However, there paucity studies regarding use stents restoring patency. The aim study was to assess efficacy safety hybrid silicon Y covered self-expanding metal (SEMS) reestablishing patency stenoses fistulas.This retrospective included 31 between January 2016 December 2019 inoperable complex malignant fistulas, managed Silicone stents, SEMS. clinical details,...
While segmentectomy is considered a viable option for small peripheral non-small-cell lung cancer, its efficacy central lesions remains uncertain. This study aimed to assess the oncological outcomes of compared ones.
We aimed to identify high-resolution computed tomography (HRCT) features useful distinguish the anaplastic lymphoma kinase gene (ALK) fusion-positive and negative lung adenocarcinomas.We included 236 surgically resected adenocarcinoma lesions, which 27 consecutive ALK (AP) 115 epidermal growth factor receptor mutation-positive 94 double-negative lesions. HRCT parameters including size, air bronchograms, pleural indentation, spiculation, tumor disappearance rate (TDR) were compared. In...
Recurrence of pneumothorax after thoracoscopic surgery is a concerning issue for thoracic surgeons. In this study, we aimed to determine the risk factors recurrence spontaneous surgery.A total 192 patients with aged <50 years who underwent from January 2010 December 2016 were included in study. Pre- and post-operative characteristics obtained medical records, recurrent non-recurrent cases compared.Fourteen (7.3%) experienced recurrence. Pneumothorax was observed more frequently <20 (P=0.041)...
Checkpoint inhibitor-related pneumonitis (CIP) is a lethal immune-related adverse event. However, the development process of CIP, which may provide insight into more effective management, has not been extensively examined. We conducted multicenter retrospective analysis 56 patients who developed CIP. Clinical characteristics, radiological features, histologic and laboratory tests were analyzed. After comprehensive analysis, we proposed acute, subacute, chronic phases CIP summarized each...
Pulmonary function following lung wedge resection is not fully understood. This study aimed to assess the influence of upon postoperative pulmonary function.We retrospectively evaluated at 3, 6, and 12 months postoperatively in 29 patients who underwent resection. The values tests (PFTs) were compared among time points using a paired t-test.The vital capacity (VC) before surgery 6 2,994±793, 2,845±799, 2,941±801, 2,964±839 mL, respectively. VC decreased 3 (P=0.002) recovered by (P=0.003...
Sarcopenia characterized by skeletal muscle loss may influence postoperative outcomes through physical decline and weakened immunity. We aimed to investigate clinical significance of sarcopenia in resected early-stage non-small cell lung cancer (NSCLC).We retrospectively reviewed 315 consecutive patients with pathologic stage I NSCLC who had undergone lobectomy systematic nodal dissection. was defined as the lowest quartile psoas area on 3rd vertebra high-resolution computed tomography...
The fissureless lobectomy or anterior technique is a novel surgical technique, which avoids dissection of the lung parenchyma over pulmonary artery during by open thoracotomy approach direct vision thoracoscopic surgery. This indicated for fused lobes. We present two cases where segmentectomy was performed using simulated three-dimensional (3D) models. 3D model and rapid prototyping provided an accurate anatomical understanding operative field in both cases. believe that construction these...
Immune checkpoint inhibitor (ICI) therapy is an emerging type of treatment for lung cancer (LC). However, hyperprogressive disease (HPD) has been observed in patients treated with ICIs that lacks a prognostic prediction model. There urgent need simple and easily implementable predictive model to predict the occurrence HPD. This study aimed establish novel scoring system based on nomogram HPD.We retrospectively identified 1473 stage III-IV LC or inoperable I-II (1147 training set, 326 testing...