A5087828930- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Renal and related cancers
- T-cell and B-cell Immunology
- Cell death mechanisms and regulation
- vaccines and immunoinformatics approaches
- RNA Interference and Gene Delivery
- SARS-CoV-2 and COVID-19 Research
- Ferroptosis and cancer prognosis
- Adipose Tissue and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Hematopoietic Stem Cell Transplantation
- MicroRNA in disease regulation
- COVID-19 Clinical Research Studies
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Retinoids in leukemia and cellular processes
- Chronic Myeloid Leukemia Treatments
- Extracellular vesicles in disease
- Cancer Genomics and Diagnostics
- Curcumin's Biomedical Applications
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
National Center for Cancer Care and Research
2017-2025
Hamad Medical Corporation
2017-2025
Qatar University
2024
Hamad bin Khalifa University
2021-2023
Peking University
2021
Peking University Cancer Hospital
2021
Translational Research in Oncology
2019
King Fahad Specialist Hospital
2013-2014
Dasman Diabetes Institute
2010-2014
Weatherford College
2011
B7-H1 molecule increases the apoptosis of tumorreactive T lymphocytes and reduces their immunogenicity. Breast cancer is second most common cause mortality after lung cancer. Direct evidence linking with has been shown in several malignancies; however, its expression breast not investigated. We used immunohistochemistry to investigate 44 specimens study correlation patients' clinicopathological parameters. The was 22 patients restricted tumor epithelium (15 44, 34% cells), but also expressed...
Abstract Introduction B7-H1 (PD-L1, CD274) is a T cell inhibitory molecule expressed in many types of cancer, leading to immune escape tumor cells. Indeed, previous reports we have shown an association expression with high-risk breast cancer patients. Methods In the current study, used immunohistochemistry, immunofluorescence and Western blot techniques investigate effect neoadjuvant chemotherapy on Results Among tested chemotherapeutic agents, doxorubicin was most effective downregulating...
Abstract Background Recent studies have demonstrated a direct involvement of B7-H1, PD-1 and FOXP3 molecules in the immune escape cancer. B7-H1 is an inhibitory molecule that binds to on T lymphocytes, while marker for regulatory cells (T regs ). We previously association B7-H1-expressing infiltrating lymphocytes (TIL) with high-risk breast cancer patients other reported FOXP3+ as bad prognostic factor tumors. Although co-existence between two types has been vitro animal models, their...
Expression profile of the toll like receptors (TLRs) on PBMCs is central to regulation proinflammatory markers. An imbalance in TLRs expression may lead several types inflammatory disorders. Furthermore, dynamic activity and associated impaired production cytokines by peripheral blood mononuclear cells (PBMCs) obese individulas remain poorly understood. Therefore, we determined perturbation (TLR2 TLR4), their adaptor proteins (MyD88, IRAK1 TRAF6) PBMCs/subcutaneous adipose tissue (AT) as...
Abstract B7‐H1, a coinhibitory molecule, plays role in immune escape of tumors. We have shown previously the expression this molecule breast cancer patients and demonstrated its association with high histological grade, progesterone estrogen receptor negative status, all which are known to direct impact on cell proliferation. In present work, we investigated effect proliferation, as measured by Ki‐67 mitotic count, induction B7‐H1. used H&E stained sections score for count 69 patients....
Abstract It has become clear that the initiation and progression of carcinomas depend not only on alterations in epithelial cells, but also changes their microenvironment. To identify these changes, we have undertaken cellular molecular characterization carcinoma-associated fibroblasts (CAF) tumor counterpart (TCF) isolated from 12 breast cancer patients. Normal (NBF) plastic surgery were used as normal control. We present evidence both CAFs TCFs are myofibroblasts show tumor-associated...
We conducted a meta-analysis to evaluate the efficacy of anti-programmed cell death 1 (PD-1)/programmed ligand (PD-L1) monotherapy or immunotherapy combined with chemotherapy and further estimated value PD-L1 expression in predicting response from anti-PD-1/PD-L1 treatments as combination chemotherapy.Clinical trial data were searched electronic databases, which evaluated PD-1/PD-L1 inhibitors non-small lung cancer (NSCLC) correlated levels.Fifteen randomized-controlled trials involving...
The constitutive activation of Janus Kinase/Signal Transducer and Activator Transcription (JAK/STAT) signal transduction is well elucidated in STAT3-mediated oncogenesis related to thyroid cancer considered be a plausible therapeutic target. Hence, we investigated whether curcumin, natural compound, can target the JAK/STAT3 signaling pathway induce cytotoxic effects papillary (PTC) cell lines (BCPAP TPC-1) derived stem-like cells (thyrospheres). Curcumin suppressed PTC survival...
Acute lymphoblastic leukemia (ALL) is a significant cancer of children resulting from the clonal proliferation lymphoid precursors with arrested maturation. Although chemotherapeutic approaches have been achieving successful remission for majority cases childhood ALL, development resistance to chemotherapy has observed. Thus, new therapeutic are required improve patient's prognosis. Therefore, we investigated anticancer potential curcumin in ALL. We tested panel B-precursor ALL (B-Pre-ALL)...
Immune checkpoint inhibitors (ICIs) including anti-PD-1 and anti-PD-L1 antibodies, have significantly changed the treatment outcomes of NSCLC patients with better overall survival. However, 15-40% still fail to respond ICIs therapy. Identification biomarkers associated responses are mandated in order increase efficacy such In this study we evaluated 27 serum-derived exosomal immuno-oncological proteins 44 cytokines/chemokines before after therapy 17 identify surrogate for...
Colon cancer (CRC) is the second leading cause of death and third most diagnosed worldwide. Although curcumin (CUR) has demonstrated a potent anticancer activity, it characterized by its poor solubility, low bioavailability, instability. This study projection from previous investigation where CUR succinylated (CUR.SA) were separately encapsulated in mannosylated-chitosan nanoparticles (CM-NPs) to form CUR-NPs CUR.SA-NPs, respectively. Here, we aim assess anti-CRC activity these two...
Head and neck cancer (HNC) is the sixth most common type, accounting for approximately 277,597 deaths worldwide. Recently, Food Drug Administration (FDA) has approved immune checkpoint blockade (ICB) agents targeting programmed death-1 (PD-1) death-ligand 1 (PD-L1) as a treatment regimen head squamous cell carcinomas (HNSCC). Studies have reported role of inhibitors targeted therapeutic regimens that unleash response against HNSCC tumors. However, overall rates to immunotherapy vary between...