A5066226581- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Advanced Breast Cancer Therapies
- Breast Lesions and Carcinomas
- Cancer Risks and Factors
- Cancer Genomics and Diagnostics
- Metastasis and carcinoma case studies
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- BRCA gene mutations in cancer
- Immunotherapy and Immune Responses
- Estrogen and related hormone effects
- Brain Metastases and Treatment
- Global Cancer Incidence and Screening
- Cancer Diagnosis and Treatment
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Bioinformatics and Genomic Networks
- Inflammatory Biomarkers in Disease Prognosis
- Retinoids in leukemia and cellular processes
- Cell death mechanisms and regulation
- CAR-T cell therapy research
King Faisal Specialist Hospital & Research Centre
2016-2025
King Saud University
2011
University of Fukui
2008
Saskatchewan Cancer Agency
1999-2005
University of Alabama at Birmingham
2000
Royal University Hospital
1998
Alberta Cancer Foundation
1996
We compared docetaxel plus doxorubicin and cyclophosphamide (TAC) with fluorouracil (FAC) as adjuvant chemotherapy for operable node-positive breast cancer.
B7-H1 molecule increases the apoptosis of tumorreactive T lymphocytes and reduces their immunogenicity. Breast cancer is second most common cause mortality after lung cancer. Direct evidence linking with has been shown in several malignancies; however, its expression breast not investigated. We used immunohistochemistry to investigate 44 specimens study correlation patients' clinicopathological parameters. The was 22 patients restricted tumor epithelium (15 44, 34% cells), but also expressed...
The T-cell inhibitory molecule PD-L1 (B7-H1, CD274) is expressed on tumor cells of a subset breast cancer patients. However, the mechanism that regulates expression in this group patients still not well-identified. We have used loss and gain function gene manipulation approach, multi-parametric flow cytometry, large scale dataset analysis immunohistochemistry tissue sections. Induction epithelial to mesenchymal transition (EMT) human mammary upregulated expression, which was dependent mainly...
Abstract Introduction B7-H1 (PD-L1, CD274) is a T cell inhibitory molecule expressed in many types of cancer, leading to immune escape tumor cells. Indeed, previous reports we have shown an association expression with high-risk breast cancer patients. Methods In the current study, used immunohistochemistry, immunofluorescence and Western blot techniques investigate effect neoadjuvant chemotherapy on Results Among tested chemotherapeutic agents, doxorubicin was most effective downregulating...
Abstract Background Recent studies have demonstrated a direct involvement of B7-H1, PD-1 and FOXP3 molecules in the immune escape cancer. B7-H1 is an inhibitory molecule that binds to on T lymphocytes, while marker for regulatory cells (T regs ). We previously association B7-H1-expressing infiltrating lymphocytes (TIL) with high-risk breast cancer patients other reported FOXP3+ as bad prognostic factor tumors. Although co-existence between two types has been vitro animal models, their...
Abstract B7‐H1, a coinhibitory molecule, plays role in immune escape of tumors. We have shown previously the expression this molecule breast cancer patients and demonstrated its association with high histological grade, progesterone estrogen receptor negative status, all which are known to direct impact on cell proliferation. In present work, we investigated effect proliferation, as measured by Ki‐67 mitotic count, induction B7‐H1. used H&E stained sections score for count 69 patients....
Abstract It has become clear that the initiation and progression of carcinomas depend not only on alterations in epithelial cells, but also changes their microenvironment. To identify these changes, we have undertaken cellular molecular characterization carcinoma-associated fibroblasts (CAF) tumor counterpart (TCF) isolated from 12 breast cancer patients. Normal (NBF) plastic surgery were used as normal control. We present evidence both CAFs TCFs are myofibroblasts show tumor-associated...
Breast cancer in young women is more aggressive with a poorer prognosis and overall survival compared to older diagnosed the disease. Despite recent research, underlying biology molecular alterations that drive nature of breast tumors associated have yet be elucidated. In this study, we performed transcriptomic profile network analyses arising Middle Eastern identify age-specific gene signatures. Moreover, studied progression using cross-species comparative genomics approach coupled copy...
Breast cancer in young Saudi women is a crucial problem. According to the 2002 annual report of National Cancer Registry, breast cancers that developed before age 40 comprise 26.4% all female comparing 6.5% USA. patients often associated with poorer prognosis, but there has been scarcity published data Middle East population.Total 867 seen at King Faisal Specialist Hospital & Research Centre (KFSH&RC) between 1986 and were reviewed. Patients divided two groups: < or = years above years. The...
The actin-bundling protein, fascin, is a member of the cytoskeletal protein family that has restricted expression in specialized normal cells. However, many studies have reported induction this various transformed cells including breast cancer While role fascin regulation cell migration been previously shown, underlying molecular mechanism remained poorly defined. We used variety immunological and functional assays to study whether regulates metastasis-associated molecules. In report we...
A major therapeutic challenge for breast cancer is the ability of cells to evade killing conventional chemotherapeutic agents. We have recently reported actin-bundling protein (fascin) as a regulator metastasis and survival. Survival patients that received chemotherapy xenograft tumour model was used assess effect on fascin-positive -negative cells. Molecular cellular assays were gain in-depth understanding relationship between fascin chemoresistance. showed significant correlation...
Introduction: There is evidence for an association between peripheral blood eosinophil count (PBEC) and response to cancer immunotherapy; however, such data limited in metastatic triple-negative breast (mTNBC). Patients & methods: This report presents patients (n = 14) who received a combination of durvalumab paclitaxel mTNBC (NCT02628132). Results: was statistically significant correlation (p 0.028) increase PBEC (>300/mm3) during treatment the therapy. Survival analysis showed...
PURPOSE: This pilot phase II study investigated the efficacy and toxicity of docetaxel with doxorubicin cyclophosphamide (TAC) as first-line chemotherapy for anthracycline-naive patients metastatic breast cancer. PATIENTS AND METHODS: Fifty-four received a total 359 courses consisting 75 mg/m 2 given intravenously (IV) over 1 hour, preceded by IV 50 500 maximum eight 3-week cycles. RESULTS: After an independent panel review, overall objective response rate was 77% (complete response, 6%)....
Breast cancer (BC) is the most common malignancy and leading cause of cancer-related death amongst women worldwide. The risk factors this disease are numerous, their prevalence varies between racial ethnic groups as well geographical regions. Therefore, we sought to delineate association socio-demographic, reproductive life-style related with breast in Arab population. Unmatched case-control study was conducted kingdom Saudi Arabia using 534 cases histologically confirmed 638 controls....
Abstract Triple‐negative breast cancer (TNBC) is a very aggressive subtype with high recurrence rate and no molecular targets for therapies. This characterized by expression/secretion of the proinvasive/metastatic interleukin‐6 (IL‐6) cytokine. In present study, we have shown that tocilizumab inhibits IL‐6/STAT3 signaling suppresses cancer/inflammatory epigenetic IL‐6/STAT3/NF‐κB positive feedback loop. Furthermore, inhibited proliferative migratory/invasiveness capacities as well...
Breast cancer remains the second cause of tumor‐related mortality in women worldwide mainly due to chemoresistance and metastasis. The metastasis are attributed a rare subpopulation with enriched stem‐like characteristics, thus called Cancer Stem Cells (CSCs). We have previously reported aberrant expression actin‐bundling protein (fascin) breast cells, which enhances their chemoresistance, enriches CSC population. intracellular mechanisms that link fascin its downstream effectors not fully...
BRCA1 promoter methylation has been detected in DNA from peripheral blood cells of both breast cancer patients and cancer-free females. However, the pathological significance this epigenetic change white (WBC) remains an open question. In study, we hypothesized that if constitutional reflects elevated risk for developing (BC), WBC harbor methylated females BC should exhibit similar molecular changes. was examined by methylation-specific PCR 155 143 The Human Breast Cancer EpiTect Methyl II...
Understanding the ethnic molecular subtype characteristics of breast cancer (BC) in Saudi women is crucial for providing comprehensive prognostic information and optimizing patient outcomes, making it essential to study their distribution impact on survival. This hospital-based cohort analyzed clinic–pathological data from 1,035 diagnosed with invasive BC followed 12 years, at King Faisal Specialist Hospital & Research Center. Cancers were classified into four subtypes: luminal A, B, human...
BACKGROUND Metaplastic breast cancer (MPBC) is a rare subtype of that difficult to manage and resistant therapy. Immunotherapy becoming promising option for care several types cancers including triple negative cancer. CASE REPORT We present case patient with chemo-refractory metastatic metaplastic-type failures 3 active lines chemotherapy. The achieved complete sustained response chemo-immunotherapy combination acceptable tolerability minimal adverse events. treatment was anti-PD-L1 antibody...
There is a paucity of literature examining the impact timing surgery after neoadjuvant chemotherapy.This study aimed to analyze time taken initiate surgical treatment following completion chemotherapy on patients' outcomes by evaluating their pathological response, overall survival (OS), and disease-free (DFS).This retrospective review 611 patients diagnosed with stage II III breast cancer that received between January 2004 December 2014. The data was collected from prospectively gathered...
Resistance to therapy is a persistent problem that leads mortality in breast cancer, particularly triple-negative cancer (TNBC). MiRNAs have become focus of investigation as tissue-specific regulators gene networks related drug resistance. Circulating miRNAs are readily accessible non-invasive potential biomarkers for TNBC diagnosis, prognosis, and drug-response. Our aim was use systems biology, meta-analysis, network approaches delineate the resistance pathways clinical outcomes associated...
Breast cancer (BC) patient who receives chemotherapy for an extended length of time may experience profound repercussions in terms metastases and clinical outcomes due to the involvement epithelial-to-mesenchymal transition (EMT) mechanism enriched stem cells (CSCs). BC that express high levels lncRNA deleted lymphocytic leukemia-2 (lncRNA DLEU2) type I tyrosine kinase-like orphan receptor ROR1 (ROR1) play roles enhanced ability activation EMT CSC induction. Here we find DLEU2 are...