A5081815398- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Congenital Diaphragmatic Hernia Studies
- Ferroptosis and cancer prognosis
- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Endometrial and Cervical Cancer Treatments
- Tracheal and airway disorders
- Immune Cell Function and Interaction
- Intraperitoneal and Appendiceal Malignancies
- COVID-19 and healthcare impacts
- Hernia repair and management
- Medical Imaging Techniques and Applications
- Appendicitis Diagnosis and Management
- Esophageal and GI Pathology
- Brain Metastases and Treatment
- Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Lung Cancer Research Studies
- Tumors and Oncological Cases
- Lymphoma Diagnosis and Treatment
- Diverticular Disease and Complications
- Cancer Research and Treatments
- Respiratory Support and Mechanisms
Hamad Medical Corporation
2010-2024
National Center for Cancer Care and Research
2020-2024
Hamad General Hospital
2010
University of Edinburgh
1977
Immune checkpoint inhibitors (ICIs) including anti-PD-1 and anti-PD-L1 antibodies, have significantly changed the treatment outcomes of NSCLC patients with better overall survival. However, 15-40% still fail to respond ICIs therapy. Identification biomarkers associated responses are mandated in order increase efficacy such In this study we evaluated 27 serum-derived exosomal immuno-oncological proteins 44 cytokines/chemokines before after therapy 17 identify surrogate for...
Background Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related morbidity and mortality worldwide. Immune checkpoint inhibitors (ICIs) including anti-PD-1 anti-PD-L1 antibodies, have significantly changed treatment outcomes with better overall survival, but only 15-40% patients respond to ICIs therapy. The search for predictive biomarkers responses warranted clinical outcomes. We aim here identify pre-treatment soluble immune molecules as surrogate tissue PD-L1 (TPD-L1)...
Background: Clear cell carcinoma of the endometrium (CCE) has a tendency to occur in mismatch repair protein deficient molecular background.Treatment with immunotherapy can predict favorable response.Case presentation: We are presenting 53-year-old female, diagnosed CCE 17 years ago, who was treated initially hysterectomy and left salpingo-oophorectomy, relapsed few months later, then pelvic mass excision sigmoidectomy.Recently, disease recurred as retroperitoneal lymphadenopathy, which...
Leptomeningeal carcinomatosis (LMC) is a known sequel of metastatic lung cancer and its treatment challenging. Nevertheless, options for LMC due to epidermal growth factor receptor-mutant (EGFR-mutant) adenocarcinoma are expanding. We present 52-year-old male patient with non-small-cell (NSCLC). The was found have L858R mutation in exon 21 the EGFR gene. He initially treated erlotinib, followed by afatinib/cetuximab, chemotherapy. Thereafter, his disease progressed LMC. Although tissue...
Background: There has been significant improvement in treating metastatic non–small-cell lung cancer (mNSCLC) over the past 2 decades. The aim of this study is to describe use tyrosine kinase inhibitors (TKIs) Qatar. This focuses on objective response rate (ORR) and reported adverse drug events (ADEs) TKIs used for management patients with mNSCLC. Methods: a descriptive retrospective cohort study. All cancers (NSCLCs) epidermal growth factor receptor (EGFR) or anaplastic lymphoma (ALK)...
Background Improving access to healthcare is crucial for patient experience, clinical safety, timeliness of care, and reducing staff pressure. The National Centre Cancer Care Research (NCCCR), the primary cancer center in Qatar, confronted challenges delivering quality care services. Aim This project aimed identify factors limiting admissions discharges at NCCCR improve average admission discharge rates by 50%. Methods study was conducted Center (NCCCR) Qatar from June 2020 December 2021....
Lung cancer is the number 1 cause of deaths in United States. The prognosis quite grim with exception stage 1. When faced several failed therapeutic regimens and rapid progression disease, considering alternative therapies such as radiopharmaceutical may be an option. We describe case a 36-y-old man lung adenocarcinoma who had imaging molecular characterization his disease 18F-FDG, 68Ga-DOTATATE, 18F-fluoride PET/CT scans that were able to shed some light on serve guide potential targeted or...
Background There is limited data on the predictive biomarkers of response to immune checkpoint blockade (ICB) treatment non-small cell lung cancer (NSCLC) patients. The main aim this prospective study was understand utility pre-treatment soluble markers as surrogate for tissue PD-L1 and predictors in locally advanced/metastatic NSCLC patients treated with ICBs. Methods conducted at National Center Cancer Care Research (NCCCR), HMC, Qatar. A total 30 Pembrolizumab/Nivolumab were enrolled...
Conference Abstract| February 01 1977 The Relative Distribution of Airflow Resistance in Normal Subjects and Patients with Airway Obstruction A. Kanbour; Kanbour 1Department Medicine, University Edinburgh Search for other works by this author on: This Site PubMed Google Scholar N. J. Douglas; Douglas M. F. Sudlow; Sudlow D. C. Flenley Clin Sci Mol Med (1977) 52 (2): 27P. https://doi.org/10.1042/cs052027Pa Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review...
Thoracic ectopic kidney is a rare congenital anomaly that often missed. We report case of diaphragmatic hernia associated with left thoracic and bowel herniation into the hemithorax. Radiological studies including chest radiology computed tomography confirmed diagnosis.
Acute appendicitis is the most common surgical case met in an emergency department. Immediate surgery results confirmation of diagnosis and control sepsis. To determine whether delay operating upon patients with acute will affect outcome or stage disease, if clinical parameters give indication severity disease medical records were reviewed retrospectively 373 appendectomized above 14 years age who diagnosed department Hamad General Hospital, State Qatar, between June September 2007; 341 as...
Abstract Background: Nonepithelial Ovarian cancers constitute about 10 % of all ovarian cancers. They are divided into Sex-cord stromal tumours (SCST) and Germ cell (GCT). The Aim is to report the experience at National Centre for Cancer Care Research (NCCCR) in Qatar. Method: This a retrospective study reviewing records patients over 7 years who presented with histopathologically diagnosed SCST GCT NCCCR between January 2010 December 2016. Results: 25 women Non-Epithelial Tumours were...