A5115599104- Amyotrophic Lateral Sclerosis Research
- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Polyomavirus and related diseases
- Neurogenetic and Muscular Disorders Research
- Studies on Chitinases and Chitosanases
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Pluripotent Stem Cells Research
- Bipolar Disorder and Treatment
- Soil Mechanics and Vehicle Dynamics
- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Organ Transplantation Techniques and Outcomes
- Diverse Scientific Research Studies
- Chronic Disease Management Strategies
- Genetics and Neurodevelopmental Disorders
- Otolaryngology and Infectious Diseases
- Macrophage Migration Inhibitory Factor
- Sustainability in Higher Education
- Prion Diseases and Protein Misfolding
- Kruppel-like factors research
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- Physical Education and Training Studies
National Institute of Epidemiology
2025
Indian Council of Medical Research
2025
National Institute of Mental Health and Neurosciences
2013-2024
Hamad Medical Corporation
2024
National Center for Cancer Care and Research
2024
University of Maryland, Baltimore
2021
University of Maryland Medical Center
2021
Pushpagiri Medical College
2021
Manchester University NHS Foundation Trust
2021
SciGenom Labs (India)
2021
Potential biomarkers to aid diagnosis and therapy need be identified for Amyotrophic Lateral Sclerosis, a progressive motor neuronal degenerative disorder. The present study was designed identify the factor(s) which are differentially expressed in cerebrospinal fluid (CSF) of patients with sporadic amyotrophic lateral sclerosis (SALS; ALS-CSF), could associated pathogenesis this disease.Quantitative mass spectrometry ALS-CSF control-CSF (from orthopaedic surgical undergoing spinal...
More than half of the individuals with hypertension remain undiagnosed in India. The National Non-Communicable Disease (NCD) program has implemented opportunistic screening to improve diagnoses. In public health facilities across 18 districts nine states India, we estimated missed opportunity for detection routine settings. each chosen districts, conducted a cross-sectional study one district hospital (DH), community centre (CHC), and three primary centres (PHCs), selected randomly. We...
The survival of motor neurons is dependent upon neurotrophic factors both during childhood and adolescence adult life. In disease conditions, such as in patients with amyotrophic lateral sclerosis (ALS), the mRNA levels trophic like brain-derived factor (BDNF), insulin-like growth factor-1 (IGF-1), fibroblast factor-2 (FGF-2), vascular endothelial are downregulated. This was replicated our vivo experimental system following injection cerebral spinal fluid (CSF) sporadic ALS (ALS-CSF)...
Cerebrospinal fluid from amyotrophic lateral sclerosis patients (ALS-CSF) induces neurodegenerative changes in motor neurons and gliosis sporadic ALS models. Search for identification of toxic factor(s) CSF revealed an enhancement the level enzyme activity chitotriosidase (CHIT-1). Here, we have investigated its upregulation a large cohort samples more importantly role pathogenesis rat model.
The incidence of invasive meningococcal disease in the UK decreased by approximately four times from 1999 to 2014, with reductions serogroup C and B disease. Lower was attributable implementation conjugate vaccine 1999, through direct indirect protection, but no implemented against Meningococcal Carriage surveys 1-3 (UKMenCar1-3), conducted 2000, 2001, were essential for understanding impact vaccination. To investigate decline incidence, we did a large oropharyngeal carriage survey 2014-15,...
Prior studies demonstrate that donor-derived cell-free DNA (dd-cfDNA) in lung transplant recipients may serve as a marker of allograft injury for detecting rejection and infection. Clinical interpretation dd-cfDNA requires understanding its biological variation stable patients order to identify abnormal results suggesting underlying dysfunction. This study establishes the reference change values (RCV) using an analytically validated assay with established analytic coefficient (CVA).The...
ABSTRACT Cellular migration is a ubiquitous feature that brings brain cells into appropriate spatial relationships over time; and it helps in the formation of functional brain. We studied patterns induced pluripotent stem cell-derived neural precursor (NPCs) from individuals with familial bipolar disorder (BD) comparison healthy controls. The BD patients also had morphological abnormalities evident on magnetic resonance imaging. Time-lapse analysis migrating was performed, through which we...
Amyotrophic Lateral Sclerosis (ALS) is a multifactorial neurodegenerative disorder with significant contribution of non-cell autonomous mechanisms to motor neuronal degeneration. Amongst plethora molecules, Fractalkine (C-X3-C motif chemokine ligand 1), and Heat Shock Protein 60 (HSP60), are key modulators microglial activation. The these molecules in Sporadic ALS (SALS) remains unexplored. To investigate this, fractalkine levels were estimated Cerebrospinal fluid (CSF) SALS patients...
Background Improving access to healthcare is crucial for patient experience, clinical safety, timeliness of care, and reducing staff pressure. The National Centre Cancer Care Research (NCCCR), the primary cancer center in Qatar, confronted challenges delivering quality care services. Aim This project aimed identify factors limiting admissions discharges at NCCCR improve average admission discharge rates by 50%. Methods study was conducted Center (NCCCR) Qatar from June 2020 December 2021....
Terminal illness is always a traumatic experience to the patients as well those who are caring them. The studies assessing knowledge and attitude of nurses towards end life care in India limited. A descriptive study was adopted assess on among student staff an exploratory step issues nurses. carried out nurses, 30 each group using standardized tools viz. Self administered questionnaire prepared by researchers Frommelt Attitude Care Dying Scale. collected data were pooled into Microsoft excel...
Myotonic dystrophy type 1 (DM1) is an incurable multisystem disease caused by a CTG-repeat expansion in the DM1 protein kinase (DMPK) gene. The OPTIMISTIC clinical trial demonstrated positive and heterogenous effects of cognitive behavioral therapy (CBT) on capacity for activity social participations patients. Through process reverse engineering, this study aims to identify druggable molecular biomarkers associated with improvement cohort.Based full blood samples collected during OPTIMISTIC,...
Abstract Background: Cerebrospinal fluid from Amyotrophic Lateral Sclerosis patients (ALS-CSF) induces neurodegenerative changes in motor neurons and gliosis sporadic ALS models. Search for identification of toxic factor(s) CSF revealed an enhancement the level enzyme activity chitotriosidase (CHIT-1). Here, we have investigated its upregulation a large cohort samples more importantly role pathogenesis rat model. Methods: CHIT-1 (n=158), non-ALS (n=12) normal (n=48) subjects were measured...