A5046436048- Genetics and Neurodevelopmental Disorders
- Bipolar Disorder and Treatment
- Pluripotent Stem Cells Research
- Neuropeptides and Animal Physiology
- Genomics and Rare Diseases
- Obsessive-Compulsive Spectrum Disorders
- Alzheimer's disease research and treatments
- Pain Mechanisms and Treatments
- Genetic Associations and Epidemiology
- Virus-based gene therapy research
- BRCA gene mutations in cancer
- Receptor Mechanisms and Signaling
- Renal and related cancers
- Tryptophan and brain disorders
- Autism Spectrum Disorder Research
- CRISPR and Genetic Engineering
- Stress Responses and Cortisol
- Neuroscience and Neural Engineering
- Neurotransmitter Receptor Influence on Behavior
- Advanced biosensing and bioanalysis techniques
- Nuclear Receptors and Signaling
- Health, Environment, Cognitive Aging
- Neuroscience and Neuropharmacology Research
- 14-3-3 protein interactions
- Epigenetics and DNA Methylation
National Institute of Mental Health and Neurosciences
2019-2024
All India Institute of Medical Sciences
2024
Laboratory of Molecular Genetics
2020
University of Pennsylvania
2011-2014
Fred Hutch Cancer Center
2006-2009
University at Buffalo, State University of New York
2005-2008
Sir Ganga Ram Hospital
2004
Indian Institute of Technology Roorkee
2002
Retroviral vector-mediated HSC gene therapy has been used to treat individuals with a number of life-threatening diseases. However, some patients SCID-X1 developed retroviral leukemia after treatment. The selective growth advantage gene-modified cells in suggests that the transgene may have played role leukemogenesis. Here we report 2 dogs and 1 macaques myeloid approximately years being transplanted overexpressed homeobox B4 (HOXB4) transduced control gammaretroviral vector did not express...
In Alzheimer's disease, progressive supranuclear palsy, and a number of other neurodegenerative diseases, the microtubule associated protein tau aggregates to form intracellular neurofibrillary tangles glial tangles, abnormal structures that are part disease pathogenesis. Disorders with aggregated called tauopathies. Presently, there no disease-modifying treatments for this class. Tau is encoded by MAPT gene. We propose reducing expression thus amount made could prevent aggregation,...
The Psychiatric Genomics Consortium (PGC) has fueled discoveries of common and rare genetic variation contributing to liability 13 psychiatric neurodevelopmental conditions. This narrative review reflects on major findings from the past half decade research by this international group investigators in five priority areas: discovery variants using GWAS; its interplay with polygenic risk; leveraging genetics go beyond diagnostic boundaries; ascribing functional attributes genomic discoveries;...
The Psychiatric Genomics Consortium (PGC) has fueled discoveries of common and rare genetic variation contributing to liability 13 psychiatric neurodevelopmental conditions. This narrative review reflects on major findings from the past half decade research by this international group investigators in five priority areas: discovery variants using GWAS; its interplay with polygenic risk; leveraging genetics go beyond diagnostic boundaries; ascribing functional attributes genomic discoveries;...
Abstract Lithium is an effective, well-established treatment for bipolar disorder (BD). However, the mechanisms of its action, and reasons variations in clinical response, are unclear. We used neural precursor cells (NPCs) lymphoblastoid cell lines (LCLs), from BD patients characterized response to lithium (using “Alda scale” “NIMH Retrospective Life chart method”), interrogate cellular phenotypes related both disease response. NPCs two biologically who differed their were compared with...
Esophageal involvement by tuberculosis is rare and commonly secondary to mediastinal lymph nodal involvement. Endoscopic ultrasound (EUS) a good modality for evaluation of both esophageal wall nodes. The objectives were study the role EUS in diagnosing tuberculosis, differentiate primary from form, assess response. Retrospective analysis data over 7 years (i.e. 2003 2009) was used. set tertiary care referral institute focused on patients diagnosed with tuberculosis. Interventions used...
The present study documents a role for brain-derived tumor necrosis factor-α (TNF) in the mechanism of action antidepressant drug desmethylimipramine (desipramine). To establish this role, field stimulation and superfusion rat hippocampal slices was employed to investigate regulation norepinephrine (NE) release by TNF. Chronic desipramine administration transforms TNF-mediated inhibition NE facilitation, dependent upon α<sub>2</sub>-adrenergic receptor activation. i.c.v. microinfusion...
In this perspective, we examine the impact of social exclusion on marginalized communities in India within STEM education and careers. The structures inequality are viewed principally along axes caste, gender, their intersectionality. India, although caste-based discrimination is illegal, affirmative action by state constitutionally mandated, caste system kept alive practices society among scientific community. Caste privilege often masquerades as "merit" its underplayed. Dalits (from most...
Though several SAPAP3 gene knockout studies in mice have implicated its role compulsivity, human failed to demonstrate association with obsessive-compulsive disorder (OCD). We examined the between allelic variants of a single nucleotide polymorphism (rs6662980) specific aspects OCD phenotype. A total 200 individuals were genotyped using TaqMan assay. All participants assessed Mini International Neuropsychiatric Interview and Yale-Brown Obsessive-Compulsive Scale, their response serotonin...
ABSTRACT Cellular migration is a ubiquitous feature that brings brain cells into appropriate spatial relationships over time; and it helps in the formation of functional brain. We studied patterns induced pluripotent stem cell-derived neural precursor (NPCs) from individuals with familial bipolar disorder (BD) comparison healthy controls. The BD patients also had morphological abnormalities evident on magnetic resonance imaging. Time-lapse analysis migrating was performed, through which we...
Abstract Bipolar disorder (BD) is a severe mental illness that can result from neurodevelopmental aberrations, particularly in familial BD, which may include causative genetic variants. In the present study, we derived cortical organoids BD patients and healthy (control) individuals clinically dense family Indian population. Our data reveal patient show anomalies, including organisational, proliferation migration defects. The reduction both number of neuroepithelial buds/cortical rosettes...
Abstract Genome-wide association studies across diverse populations may help validate and confirm genetic contributions to risk of disease. We estimated the extent population stratification as well predictive accuracy polygenic scores (PGS) derived from European samples a data set India. analysed 2685 two sets, neurodevelopmental study (cVEDA) hospital-based sample bipolar affective disorder (BD) obsessive-compulsive (OCD). Genotyping was conducted using Illumina’s Global Screening Array....