Ravi Kumar Nadella
A5026501849- Bipolar Disorder and Treatment
- Genetics and Neurodevelopmental Disorders
- Genetic Associations and Epidemiology
- Autism Spectrum Disorder Research
- Obsessive-Compulsive Spectrum Disorders
- Genomics and Rare Diseases
- Circadian rhythm and melatonin
- Child and Adolescent Psychosocial and Emotional Development
- Psychological and Temporal Perspectives Research
- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Eating Disorders and Behaviors
- Adolescent and Pediatric Healthcare
- Ion Transport and Channel Regulation
- Ion channel regulation and function
- Family Caregiving in Mental Illness
- Receptor Mechanisms and Signaling
- Health disparities and outcomes
- Pluripotent Stem Cells Research
- Genomic variations and chromosomal abnormalities
- Electroconvulsive Therapy Studies
- Intergenerational Family Dynamics and Caregiving
- Treatment of Major Depression
- Genetic and Kidney Cyst Diseases
- Diabetes and associated disorders
National Institute of Mental Health and Neurosciences
2017-2024
The Royal Melbourne Hospital
2023-2024
Butabika Hospital
2022
Yashoda Hospital
2022
Hôpitaux Universitaires Henri-Mondor
2019
Inserm
2019
Institut Pasteur
2019
University of Helsinki
2019
Helsinki University Hospital
2019
University of Tartu
2019
Abstract Lithium is an effective, well-established treatment for bipolar disorder (BD). However, the mechanisms of its action, and reasons variations in clinical response, are unclear. We used neural precursor cells (NPCs) lymphoblastoid cell lines (LCLs), from BD patients characterized response to lithium (using “Alda scale” “NIMH Retrospective Life chart method”), interrogate cellular phenotypes related both disease response. NPCs two biologically who differed their were compared with...
Aim Severe mental illnesses (SMI), such as bipolar disorder and schizophrenia, are highly heritable, have a complex pattern of inheritance. Genome‐wide association studies detect part the heritability, which can be attributed to common genetic variation. Examination rare variants with next‐generation sequencing may add understanding architecture SMI. Methods We analyzed 32 ill subjects from eight multiplex families 33 healthy individuals using whole‐exome sequencing. Prioritized were...
Objective To confirm prior findings that the larger maximum monthly increase in solar insolation springtime, younger age of onset bipolar disorder. Method Data were collected from 5536 patients at 50 sites 32 countries on six continents. Onset occurred 456 locations 57 countries. Variables included insolation, birth‐cohort, family history, polarity first episode and country physician density. Results There was a significant, inverse association between location, onset. This effect reduced...
Adverse childhood experiences are linked to the development of a number psychiatric illnesses in adulthood. Our study examined pattern adverse and their relation age onset major conditions individuals from families that had ⩾2 first-degree relatives with (multiplex families), identified as part an ongoing longitudinal study.Our sample consisted 509 215 families. Of these, 268 were affected, i.e., diagnosed bipolar disorder (n = 61), obsessive-compulsive 58), schizophrenia 52), substance...
Dysfunction in inwardly rectifying potassium channel Kir4.1 has been implicated SeSAME syndrome, an autosomal-recessive (AR), rare, multi-systemic disorder. However, not all neurological, intellectual disability, and comorbid phenotypes syndrome can be mechanistically linked solely to dysfunction.We therefore performed whole-exome sequencing identified additional genetic risk-elements that might exert causative effects either alone or concert with a family diagnosed syndrome.Two variant...
ABSTRACT Cellular migration is a ubiquitous feature that brings brain cells into appropriate spatial relationships over time; and it helps in the formation of functional brain. We studied patterns induced pluripotent stem cell-derived neural precursor (NPCs) from individuals with familial bipolar disorder (BD) comparison healthy controls. The BD patients also had morphological abnormalities evident on magnetic resonance imaging. Time-lapse analysis migrating was performed, through which we...
Abstract Objectives Bipolar disorder (BD) is a neuropsychiatric with complex pattern of inheritance. Although many genetic studies have been conducted on BD, its correlates remain uncertain. This study was aimed at identifying the underpinnings in an Indian family, which has under comprehensive clinical evaluation and follow‐up for over 12 years. Methods We analysed four‐generation family several members diagnosed BD employing combination linkage exome analysis . Results obtained suggestive...
Abstract We aimed to characterize potential transdiagnostic neurocognitive endophenotypes in a large cohort of multiplex families affected with two or more individuals having major psychiatric illness(MPI) i.e., schizophrenia(SCZ), bipolar disorder(BPAD), substance use disorders(SUD) and obsessive-compulsive disorder(OCD). recruited 640 that included 256 MPI, 227 their unaffected first-degree relatives(FDR) 157 population healthy-controls(PHC). Neurocognitive battery assessments executive...
The association of the Val66Met (rs6265) polymorphism in brain-derived neurotrophic factor (BDNF) gene with bipolar disorder (BD) and response to lithium treatment has been suggested, though inconsistently. considerable diversity allele frequency across different populations contributes this. There is no data from South Asia till date. Hence, we examined this BD cases India, its response.BD patients (N = 301) were recruited clinical services National Institute Mental Health Neurosciences...
The glutamate transporter gene SLC1A1 has been shown to have an association with obsessive-compulsive disorder (OCD), and serotonin reuptake inhibitor (SRI) treatment response. One polymorphism (rs3056) in associated altered brain volumes OCD. We investigated the of this OCD its relationship various clinical parameters, including age onset, disease severity, insight, factor analyzed symptom dimensions OCD, SRI Three hundred seventy seven patients (DSM–IV) aged between 18 60 years were...
Abstract Accelerator program for discovery in brain disorders using stem cells (ADBS) is an ongoing longitudinal study investigating the neurobiological aspects of five psychiatric (Alzheimer’s dementia, bipolar disorder, obsessive-compulsive substance use disorder or schizophrenia) India. The uses several techniques (brain-imaging, psychophysics, neuropsychology, next-generation sequencing, cellular models), and in-depth clinical assessments a cohort from multiple-affected families. This...
Whole Exome Sequencing (WES) studies provide important insights into the genetic architecture of serious mental illness (SMI). Genes that are central to shared biology SMIs may be identified by WES in families with multiple affected individuals diverse SMI (F-SMI). We performed 220 from 75 F-SMI and 60 unrelated controls. Within pedigree prioritization employed criteria rarity, functional consequence, sharing ≥ 3 members. Across sample, gene gene-set-wide case-control association analysis...
Background: Obsessive-compulsive disorder (OCD) is a heterogeneous illness, and emerging evidence suggests that different symptom dimensions may have distinct underlying neurobiological mechanisms. We aimed to look for familial patterns in the occurrence of these sample families with at least two individuals affected OCD. Methods: Data from 153 (total number diagnosed DSM-5 OCD = 330) recruited as part Accelerator Program Discovery Brain Disorders using Stem Cells (ADBS) was used current...