Mathew Varghese

ORCID: 0000-0001-5670-5710
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About
Contact & Profiles
Research Areas
  • Dementia and Cognitive Impairment Research
  • Mental Health Treatment and Access
  • Health disparities and outcomes
  • Alzheimer's disease research and treatments
  • Functional Brain Connectivity Studies
  • Intergenerational Family Dynamics and Caregiving
  • Schizophrenia research and treatment
  • Child and Adolescent Psychosocial and Emotional Development
  • Family Caregiving in Mental Illness
  • Aging, Elder Care, and Social Issues
  • Advanced Neuroimaging Techniques and Applications
  • Trauma and Emergency Care Studies
  • Bipolar Disorder and Treatment
  • Injury Epidemiology and Prevention
  • Genetic Associations and Epidemiology
  • Healthcare Systems and Reforms
  • Health, Environment, Cognitive Aging
  • Agriculture and Farm Safety
  • COVID-19 Clinical Research Studies
  • Orthopedic Surgery and Rehabilitation
  • Neurological Disease Mechanisms and Treatments
  • Treatment of Major Depression
  • Infectious Diseases and Tuberculosis
  • Emergency and Acute Care Studies
  • Mitochondrial Function and Pathology

National Institute of Mental Health and Neurosciences
2016-2025

St.John's Medical College Hospital
2023-2025

St. Stephen’s Hospital
2009-2024

Institute of Medical Sciences
2024

Manchester University NHS Foundation Trust
2024

Royal Brompton Hospital
2021-2023

National Institute of Mental Health
2019-2023

Institute of Mental Health and Neurosciences
2023

St. John's School
2023

Weill Cornell Medicine
2020-2022

Mental disorders are among the leading causes of non-fatal disease burden in India, but a systematic understanding their prevalence, burden, and risk factors is not readily available for each state India. In this report, we describe prevalence mental disorder states from 1990 to 2017.We used all accessible data multiple sources estimate disorders, years lived with disability (YLDs), disability-adjusted life-years (DALYs) caused by these India 2017, as part Global Burden Diseases, Injuries,...

10.1016/s2215-0366(19)30475-4 article EN cc-by The Lancet Psychiatry 2019-12-23

Background Observational evidence suggests that community-based services for people with schizophrenia can be successfully provided by community health workers, when supervised specialists, in low-income and middleincome countries.We did the COmmunity care People Schizophrenia India (COPSI) trial to compare eff ectiveness of a collaborative intervention standard facility-based care. MethodsWe multicentre, parallel-group, randomised controlled at three sites between Jan 1, 2009 Dec 31,...

10.1016/s0140-6736(13)62629-x article EN cc-by-nc-nd The Lancet 2014-03-05
Gautham Melur Sukumar Gopalkrishna Gururaj Mathew Varghese Vivek Benegal Girish N. Rao and 95 more Arun Kokane Bir Singh Chavan PK Dalal Daya Ram Kangkan Pathak Raj Kumar Singh Lokesh Kumar Singh Pradeep Sharma Pradeep Kumar Saha Chellamuthu Ramasubramanian Ritambhara Mehta Theerthankara Meethal Shibukumar Sonia P. Deuri Mousumi Krishnatreya Vijay Gogoi H. Sobhana Saumik Sengupta Indrajeet Banerjee Sameer Sharma A. Giri Abhay Kavishvar Kamlesh Rushikray Dave Naresh T Chauhan Vinod Kumar Sinha N. Goyal Jayakrishnan Thavody PK Anish Thomas Bina Abhijit Pakhare Pankaj Mittal Sukanya Ray Rajni Chatterji Brogen Singh Akoijam Heramani Singh Gojendro Priscilla Kayina L Roshan Singh Subhash Das Sonia Puri Rohit Garg Amita Kashyap Yogesh Satija Kusum Lata Gaur Divya Sharma R. Sathish M. Selvi Krishnaraj SK Singh Vivek Agarwal Eesha Sharma Sujita Kumar Kar Raghunath Misra Rajashri Neogi Debasish Sinha Soumyadeep Saha A Halder B. A. Aravind Senthil Amudhan S Pradeep Banandur D.K. Subbakrishna Thennaarasu P Marimuthu B Binu Kumar Sanjeev Jain Y.C. Janardhan Reddy T Jagadisha PT Sivakumar Prabhat Chand Kesavan Muralidharan Venkata Senthil Kumar Reddi Naveen Kumar C Krishna Prasad Muliyala T. S. Jaisoorya C Narayanaswamy Janardhanan Mahendra Prakash Sharma L. N. Suman S Paulomi Keshav Kumar Manoj Kumar Sharma M. Manjula Poornima Bhola BN Roopesh M. Thomas Kishore S Veena K Aruna Rose Mary Nitin Anand Shobha Srinath Satish Chandra Girimaji Kommu John Vijayasagar Sekar Kasi D. Muralidhar R. Dhanasekara Pandian Ameer Hamza N Janardhana Eleanor Raj Gobinda Majhi

Background: Recognizing the need for good quality, scientific and reliable information strengthening mental health policies programmes, National Mental Health Survey (NMHS) of India was implemented by Institute Neurosciences (NIMHANS), Bangalore, in year 2015–2016. Aim: To estimate prevalence, socio-demographic correlates treatment gap morbidity a representative population India. Methods: NMHS conducted across 12 Indian states where trained field investigators completed 34,802 interviews...

10.1177/0020764020907941 article EN International Journal of Social Psychiatry 2020-03-04

<h2>Summary</h2><h3>Background</h3> A systematic understanding of suicide mortality trends over time at the subnational level for India's 1·3 billion people, 18% global population, is not readily available. Thus, we aimed to report deaths, and heterogeneity in its distribution between states India from 1990 2016. <h3>Methods</h3> As part Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2016, estimated death rates (SDRs) both sexes each state We used various data sources estimating...

10.1016/s2468-2667(18)30138-5 article EN cc-by The Lancet Public Health 2018-09-12

Abstract Objectives Internet‐based interventions involving elements of cognitive behavior therapy, psychoeducation, relaxation and skills training for caregivers people with dementia have been found to be promising in Western countries. Given these outcomes, the adapted version a multi‐component online caregiver support program World Health Organization, called iSupport, was tested feasibility preliminary effectiveness India. Methods One hundred fifty‐one family members diagnosis Alzheimer's...

10.1002/gps.5502 article EN International Journal of Geriatric Psychiatry 2021-01-25

Abstract Introduction Prior estimates of dementia prevalence in India were based on samples from selected communities, inadequately representing the national and state populations. Methods From Longitudinal Aging Study (LASI) we recruited a sample adults ages 60+ administered rich battery neuropsychological tests an informant interview 2018 through 2020. We obtained clinical consensus rating status for subsample ( N = 2528), fitted logistic model this subsample, then imputed all other LASI...

10.1002/alz.12928 article EN cc-by-nc-nd Alzheimer s & Dementia 2023-01-13

Road Traffic injuries (RTI) are among the top ten leading causes of death in world resulting 1.35 million deaths every year, about 93% which occur low- and middle-income countries (LMICs). Despite several global resolutions to reduce traffic injuries, they have continued grow many countries. Many high-income successfully reduced RTI by using a public health approach implementing evidence-based interventions. As LMICs develop their highway infrastructure, adopting similar scientific towards...

10.1002/cl2.1367 article EN cc-by Campbell Systematic Reviews 2024-01-03

Stigma contributes greatly to the burden of schizophrenia and is a major obstacle recovery, yet, little known about subjective experiences those directly affected in low middle income countries. This paper aims describe stigma discrimination people living with (PLS) three sites India identify factors influencing negative discrimination. The study used mixed methods was nested randomised controlled trial community care for schizophrenia. Between November 2009 October 2010, data on four...

10.1016/j.socscimed.2014.10.035 article EN cc-by Social Science & Medicine 2014-10-18

The National Mental Health Survey (NMHS) of India was undertaken with the objectives (1) estimating prevalence and patterns various mental disorders in representative Indian population (2) identifying treatment gap, healthcare utilisation, disabilities impact disorders. This paper highlights findings pertaining to depressive (DD) from NMHS.

10.1136/bmjopen-2018-027250 article EN cc-by-nc BMJ Open 2019-06-01

Stigma associated with schizophrenia significantly affects family caregivers, yet few studies have examined the nature and determinants of stigma its relationship to their knowledge about condition. This paper describes experiences reported by primary caregivers people living (PLS) in India. The study used mixed methods was nested a randomised controlled trial community care for schizophrenia. Between November 2009 October 2010, data on caregiver functional outcomes were collected from...

10.1016/j.socscimed.2017.01.061 article EN cc-by Social Science & Medicine 2017-02-02

Background: Common mental disorders, such as mood, anxiety, and substance use are significant contributors to disability globally, including India. Available research is, however, limited by methodological issues heterogeneities. Aim: The present paper focuses on the 12-month prevalence treatment for disorders in Materials Methods: As part of World Health Organization Mental (WMH) Survey Initiative, India, study was conducted at eleven sites. However, current household sample 24,371 adults...

10.4103/psychiatry.indianjpsychiatry_333_16 article EN cc-by-nc-sa Indian Journal of Psychiatry 2017-01-01

Elderly have increased risk for cognitive impairment and dementia. Yoga therapy may be helpful in elderly to improve function.We examined the benefits of yoga-based intervention compared with waitlist control group on function residents homes.Single blind controlled study block randomization homes.Study sample included yoga (n=62) (n=58). A total 87 subjects (yoga=44, waitlist=43) completed period 6 months. received daily sessions 1 month, weekly until 3(rd) month encouraged continue...

10.4103/0019-5545.116308 article EN cc-by-nc-sa Indian Journal of Psychiatry 2013-01-01

Yoga as a life-style practice has demonstrated beneficial effects. The role of yoga in the elderly for such benefits merits investigation.The aim this study is to examine effects intervention on quality-of-life (QOL) and sleep quality living old age homes.Single blind controlled with block randomization homes.A total 120 subjects from nine homes were randomized group (n=62) waitlist (n=58). Subjects given daily 1 month weekly until 3 months encouraged without supervision 6 months. received...

10.4103/0019-5545.116310 article EN cc-by-nc-sa Indian Journal of Psychiatry 2013-01-01

Understanding the burden and pattern of mental disorders as well mapping existing resources for delivery health services in India, has been a felt need over decades. Recognizing this necessity, Ministry Health Family Welfare, Government commissioned National Mental Survey (NMHS) year 2014–15. The NMHS aimed to estimate prevalence India identify current treatment gaps, patterns health-care seeking, service utilization patterns, along with an understanding impact disability due these...

10.1371/journal.pone.0205096 article EN cc-by PLoS ONE 2018-10-25

Despite their higher prevalence, the Common Mental Disorders (CMDs) are under-recognized and under-treated resulting in huge disability. India, home to one-fifth of global population, could offer insights for organizing better services CMDs. However, prevalence resultant disability general population is unknown, consequently, gaps management or plan enormous, by default overlooked.Estimating current disability, socioeconomic impact, treatment gap CMDs a nationally representative sample from...

10.4103/indianjpsychiatry.indianjpsychiatry_865_21 article EN cc-by-nc-sa Indian Journal of Psychiatry 2022-01-01

Understanding the differences between various instruments for assessing depression will help researchers and health practitioners to choose a more appropriate tool develop framework enhance resilience mental problems in older population. The current study aimed compare 10-item Center Epidemiological Studies-Depression (CES-D) scale with Composite International Diagnostic Interview-Short Form (CIDI-SF) measuring depressive symptoms Indians. Data came from first wave of Longitudinal Aging...

10.1186/s12888-025-06671-0 article EN cc-by-nc-nd BMC Psychiatry 2025-03-14

Dementia and depression are mental health problems that commonly encountered in neuropsychiatric practice the elderly. Approximately, half of patients with late-onset have cognitive impairment. The prevalence dementias has been reported to be between 9 68%. Depression both proposed a risk factor for dementia as well prodrome dementia. This article is selective literature review complex relationship two conditions covering definitions, epidemiology, related concepts, treatment, emerging...

10.4103/0972-2327.74248 article EN cc-by-nc-sa Annals of Indian Academy of Neurology 2010-01-01

Arsenic, a contaminant of groundwater and irrigated crops, is global public health hazard. Exposure to low levels arsenic through food extends well beyond the areas with high content in water.

10.1001/jamanetworkopen.2023.12810 article EN cc-by-nc-nd JAMA Network Open 2023-05-12

Introduction India, with its rapidly aging population, faces an alarming burden of dementia. We implemented DSM-5 criteria in large-scale, nationally representative survey data India to characterize the prevalence mild and major Neurocognitive disorder. Methods The Harmonized Diagnostic Assessment Dementia for Longitudinal Aging Study (LASI-DAD) (N = 4,096) is a cohort study using multistage area probability sampling methods. Using neuropsychological testing informant reports, we defined...

10.1371/journal.pone.0297220 article EN cc-by PLoS ONE 2024-02-07
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