A5064633776- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Transcranial Magnetic Stimulation Studies
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Health disparities and outcomes
- Mental Health Treatment and Access
- Intergenerational Family Dynamics and Caregiving
- Neurological Disease Mechanisms and Treatments
- Aging, Elder Care, and Social Issues
- Health and Well-being Studies
- COVID-19 and Mental Health
- Aging and Gerontology Research
- Neurobiology of Language and Bilingualism
- Telemedicine and Telehealth Implementation
- Digital Mental Health Interventions
- Advanced MRI Techniques and Applications
- Schizophrenia research and treatment
- Religion, Ecology, and Ethics
- Spatial Neglect and Hemispheric Dysfunction
- Family Caregiving in Mental Illness
- Genetic Associations and Epidemiology
- Folate and B Vitamins Research
- Nutritional Studies and Diet
- Healthcare Decision-Making and Restraints
National Institute of Mental Health and Neurosciences
2015-2024
National Institute of Disaster Management
2023
Madras Institute of Development Studies
2020
Government Medical College
2016
Annamalai University
2015
Cheshire and Wirral Partnership NHS Foundation Trust
2007
Cheshire West and Chester
2007
This paper examines the impact of COVID-19 pandemic on migration. The rapid spread caught countries across world off guard, resulting in widespread lockdowns that clamped down mobility, commercial activities and social interactions. In India, precipitated a severe 'crisis mobility', with migrant labourers many major cities seeking to return their hometowns. Their desperate attempts home by any means available rendered lockdown ineffective several areas, prompting clashes authorities,...
Abstract Introduction Prior estimates of dementia prevalence in India were based on samples from selected communities, inadequately representing the national and state populations. Methods From Longitudinal Aging Study (LASI) we recruited a sample adults ages 60+ administered rich battery neuropsychological tests an informant interview 2018 through 2020. We obtained clinical consensus rating status for subsample ( N = 2528), fitted logistic model this subsample, then imputed all other LASI...
Abstract Anodal transcranial direct current stimulation(tDCS) is known to improve cognition in patients with mild cognitive impairment (MCI) and Alzheimer’s disease(mild AD). We aimed examine the brain functional alterations accompanying improvement performance following anodal tDCS at left dorsolateral prefrontal cortex(DLPFC) a sample of early AD (N=40; MCI, n= 19 & AD, n=21) using magnetic resonance imaging (fMRI) magnetoencephalography(MEG). The showed significant improvements...
Early cell death is a feature of neurodegenerative disorders. Telomere shortening related to premature cellular senescence and could be marker for pathology in neurological diseases. Relative telomere length dementia (N=70), Huntington's disease (N=35), ataxia telangiectasia (N=9), age-group matched control samples (N=105) was measured as relative copy/single copy gene ratios. Individuals with had the lowest ratio (0.21), followed by (0.31) (0.48). The younger group highest (1.07). reduced...
Background/objectives Alzheimer's disease (AD) is a progressive neurodegenerative condition where in early diagnosis and interventions are key policy priorities dementia services research. We studied the functional structural connectivity mild AD to determine nature of changes that coexist with neurocognitive deficits stages AD. Methods Fifteen subjects 15 cognitively healthy controls (CHc) matched for age gender, underwent detailed assessment magnetic resonance imaging (MRI) resting state...
ABSTRACT Background: Intimate partner violence (IPV)/domestic is one of the significant public health problems, but little known about barriers to disclosure in tertiary care psychiatric settings. Methodology: One hundred women seeking inpatient or outpatient services at a setting were recruited for study using purposive sampling. A semi-structured interview was administered collect information from with mental illness experiencing IPV know their help-seeking behaviors, reasons...
There is emerging evidence that there are shared genetic, environmental and developmental risk factors in psychiatry, cut across traditional diagnostic boundaries. With this background, the Discovery biology of neuropsychiatric syndromes (DBNS) proposes to recruit patients from five different (schizophrenia, bipolar disorder, obsessive compulsive Alzheimer's dementia substance use disorders), identify those with multiple affected relatives, invite these families participate study. The will...
Abstract Lithium is an effective, well-established treatment for bipolar disorder (BD). However, the mechanisms of its action, and reasons variations in clinical response, are unclear. We used neural precursor cells (NPCs) lymphoblastoid cell lines (LCLs), from BD patients characterized response to lithium (using “Alda scale” “NIMH Retrospective Life chart method”), interrogate cellular phenotypes related both disease response. NPCs two biologically who differed their were compared with...
Psychiatric illnesses are an important contributor of morbidity and mortality in older adults. There is increase adults with psychiatric disorders paralleling their growth absolute numbers. This leads to challenges mental health care service delivery. Several barriers that exists our community hinder from receiving care. Additionally, lack adequate human resources geriatric compounds the problem. Telemedicine, though not new other fields medicine, relatively practice psychiatry India....
Abstract The Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) is a nationally representative in-depth study cognitive aging and dementia. We present publicly available dataset harmonized measures 4,096 adults 60 years age older India, collected across 18 states union territories. Blood samples were obtained to carry out whole blood serum-based assays. Results are included venous specimen datafile that can be linked LASI-DAD dataset. A global...
Blood tests are in need, the clinical diagnosis of Alzheimer's disease (AD) as minimally invasive and less expensive alternatives to cerebrospinal fluid neuroimaging methods. On these lines, single molecule array (Simoa) analysis amyloid-β (Aβ42), total tau (t-tau), phospho-tau (p-tau 181), neurofilament L (NfL) plasma samples AD subjects, healthy controls (HC), non-AD subjects was conducted. Findings from this study suggest that a panel multiple biomarkers (NfL, Aβ42, t-tau, p-tau 181)...
To evaluate the ApoE gene polymorphism among patients with dementia from southern India.Persons attending a geriatric clinic in hospital setting located India and matched controls were recruited. All subjects evaluated on standard assessments diagnosed according to ICD-10; genotyping was done at apolipoprotein E (ApoE) locus.The study comprised 212 cases 195 controls. The ApoE4 allele significantly more prevalent (λ = 0.18 vs. λ 0.07; p 0.0018), especially Alzheimer's disease subgroup (n...
The sociocultural changes associated with globalization and development have weakened the traditional values family support systems for senior citizens (age 60 years above). There is an increase in prevalence of elder abuse difficulties getting appropriate care support. This has mandated legal measures to protect rights provide them by other stakeholders. Consequent being signatory "Madrid International Plan Action on Ageing, 2002," several countries, including India, introduced legislation...