A5103268324- Respiratory Support and Mechanisms
- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Sedative Agents
- Cardiac Arrest and Resuscitation
- Airway Management and Intubation Techniques
- Anesthesia and Pain Management
- Renal function and acid-base balance
- Cardiac electrophysiology and arrhythmias
- Nosocomial Infections in ICU
- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Neuroscience of respiration and sleep
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Nitric Oxide and Endothelin Effects
- Intensive Care Unit Cognitive Disorders
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Tracheal and airway disorders
- Heart Rate Variability and Autonomic Control
- Sepsis Diagnosis and Treatment
- Virus-based gene therapy research
- Thermal Regulation in Medicine
- Pediatric Pain Management Techniques
Government of Western Australia Department of Health
2023-2024
University of Nottingham
2024
University at Buffalo, State University of New York
1999-2023
Manchester University NHS Foundation Trust
2022
University of Wisconsin–Madison
2012
VA Western New York Healthcare System
2011
Buffalo VA Medical Center
2006
Buffalo State University
1999-2005
Toronto Western Hospital
2001
Czech Academy of Sciences, Institute of Microbiology
2000
Abstract Objective To estimate the prevalence of long COVID among Western Australian adults, a highly vaccinated population whose first major exposure to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) was during 2022 Omicron wave, and assess its impact on health service use return work or study. Study design Follow‐up survey (completed online by telephone). Setting, participants Adult Australians surveyed 90 days after positive SARS‐CoV‐2 test results (polymerase chain reaction...
We recently reported a biphasic injury pattern of nonlethal acid aspiration pneumonitis in rats. The first phase consisted the immediate effects direct tissue injury, and second was associated with neutrophilic inflammatory response. Using this model, present report examines possible role neutrophils, oxidants, proteases pathogenesis lung injury. Acid induced by instillation saline/HCl, pH = 1.25, into trachea Lung assessed measuring degree alveolar capillary permeability to 125I-labeled...
Experimental aspiration pneumonitis studies in general have focused on the pathogenesis of acidic component lung injury, although injury produced by particulate gastric contents largely has been ignored. The present study compares inflammatory potential small particles to and examines their interaction. Washed filtered rat food particles, 2–30 μ were resuspended saline/HCl, pH = 5.3 or 1.25 at different particle densities instilled intratracheally into anesthetized rats. Nonlethal was...
A prospective cohort study of 489 pediatric patients was performed to investigate the prevalence perioperative respiratory complications and symptomatology in children presenting for myringotomy with upper tract infections (URIs). All undergoing received halothane N2O/O2 anesthesia administered via face mask. Information on symptoms obtained from recovery room records, by standardized questionnaire. There were no significant differences between asymptomatic (1.23%), symptomatic fulfilling...
The Purpose of this stud?/ was to develop a reproducible model acute acid aspiration-induced lung injury in the rat explore pathophysiology aspiration pneumonitis. A biphasic pattern observed with peaks at 1 hr and 4 hr. Histologic studies revealed significant increases neutrophils alveolar interstitial space. These suggest that results injury. We hypothesize first phase from direct physiochemical process or is mediated via afferent (capsaicin sensitive) nerves both. second phase, occurring...
To assess the predictive accuracy of serum procalcitonin in distinguishing bacterial aspiration pneumonia from pneumonitis.Prospective observational study.Intensive care unit a university-affiliated hospital.Sixty-five consecutive patients admitted with pulmonary and seven control subjects intubated for airway protection.None.Quantitative cultures bronchoalveolar lavage fluid were conducted on all participants at time admission. Serial levels measured day 1 3 using enzyme-linked fluorescent...
Background Aspiration pneumonitis is characterized by proteinaceous pulmonary edema and acute infiltration of neutrophils into the alveolar space. This study examined role proinflammatory cytokine, tumor necrosis factor-alpha (TNF-alpha), on pathogenesis injury produced different components that may be present in aspirate, acid, or gastric particles. Methods Rats were injured intratracheal instillation a vehicle containing acid TNF-alpha concentration bronchoalveolar lavage fluid was...
Cisplatin, a widely used anticancer drug, preferentially damages outer hair cells (OHCs) of the inner ear. In this study, an antibody microarray was to identify early changes in protein expression rat cochlea induced by cisplatin. Only small hearing thresholds (4−34 dB elevation) were detected two days after cisplatin treatment (12 mg/kg). OHC function, measured otoacoustic emissions, slightly depressed (10 dB), and little or no receptor cell loss observed. However, large 19 proteins...
Summary Background Anti‐drug antibodies are associated with treatment failure to anti‐TNF agents in patients inflammatory bowel disease (IBD). Aim To assess whether immunogenicity a patient's first agent would be the second, irrespective of drug sequence Methods We conducted UK‐wide, multicentre, retrospective cohort study report rates and second therapies 1058 IBD who underwent therapeutic monitoring for both infliximab adalimumab. The primary outcome was agent, defined at any timepoint as...
Hyperoxia increases pulmonary damage after acid aspiration.We hypothesize that free radicals play a role in acute lung injury. To examine this hypothesis, we injured rats by intratracheal instillation of acidic isotonic sodium chloride solution (NS) (pH 1.25); NS + gastric particles (particle pH 5.3); or 1.25). Animals were exposed to 98% oxygen air for 5 h. Superoxide (HO2) generation was measured either an aliquot white blood cells (WBCs) recovered from bronchoalveolar lavage (BAL) blood....
Halothane, enflurane, and isoflurane were evaluated for antifibrillatory efficacy compared with lidocaine, propranolol, procainamide, verapamil in a canine acute left anterior descending (LAD) coronary artery occlusion/reperfusion model basal pentobarbital anesthesia. Of the antiarrhythmic drugs, only prevented ventricular fibrillation during occlusion reperfusion. Halothane 1% inspired after 15 min showed similar protection. Enflurane 2.5% resulted significant protection but caused...
Summary A patient suffering from severe psychiatric depression underwent a course of electroconvulsive therapy. marked rise in systemic arterial pressure, heart rate and plasma catecholamines response to therapy was attenuated by β‐receptor blockade using propranolol. The significance mechanism this attenuation are discussed.
The analgesic properties of α2-agonists are well known. In experimental models, tumor necrosis factor (TNF)-α regulates adrenergic responses in the brain. Constitutive TNF-α, brain regions involved pain perception, is decreased after administration clonidine. We investigated patients undergoing lower-extremity revascularization. Seven were treated with clonidine 0.2 mg per os (low), and three received 0.4 (high) before surgery. Eight placebo served as controls. Continuous spinal anesthesia...
Previously we have demonstrated that prolonged exposure to 100% ambient oxygen leads a marked loss in functional lung volume and compliance, hypoxemia, surfactant system abnormalities similar acute respiratory distress syndrome (ARDS). However, 50% administration is believed be safe most clinical settings. In the present study, evaluated effects of 24-h rabbits immediately following experimental gastric acid aspiration. Mild but no changes mortality, volume, metabolism, or edema formation...
The effect of halothane anesthesia on the influenza A specific immune response and pathogenesis infection was evaluated in mice. Three-wk-old CD-1 mice were anesthetized with either 2% for 2 h or ketamine (100 mg/kg intraperitoneally) subsequently inoculated intranasally a sublethal dose type A/PR/8/34 virus. Bronchoalveolar lavage performed animals from each group at 4 postinoculation daily thereafter 14 days. Total differential white blood cell counts measured fluid lungs examined...
Volatile anesthetics inhibit phagocytic cell function, yet little is known about their effects on target tissues or the tissue response to stimulated phagocytes. Experiments were performed determine how exposure halothane and isoflurane changes rat pulmonary artery endothelial (RPAEC) viability in toxic oxygen metabolites produced by cells. RPAECs grown monolayer culture. The monolayers treated with phorbol myristate acetate (PMA) -stimulated human neutrophils at an effector-to-target ratio...