A5030765824- Heart Failure Treatment and Management
- Air Quality and Health Impacts
- Cardiac Arrest and Resuscitation
- Cardiac electrophysiology and arrhythmias
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Pharmacogenetics and Drug Metabolism
- Botanical Studies and Applications
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Microplastics and Plastic Pollution
- Problem and Project Based Learning
- Heart Rate Variability and Autonomic Control
- Atrial Fibrillation Management and Outcomes
- Lipoproteins and Cardiovascular Health
- Pharmaceutical Practices and Patient Outcomes
- Electrolyte and hormonal disorders
- Cholinesterase and Neurodegenerative Diseases
- Analytical Methods in Pharmaceuticals
- Potassium and Related Disorders
- Mechanical Circulatory Support Devices
- Innovative Teaching Methods
- Climate Change and Health Impacts
- Diabetes Treatment and Management
University of New Mexico
2016-2025
Barry Callebaut (Belgium)
2022
University of Michigan
2008-2018
Michigan Medicine
1995-2018
Riyadh Armed Forces Hospital
2016
VA Ann Arbor Healthcare System
2016
The Ohio State University
2016
Western University of Health Sciences
2009
Michigan United
2008
Eastern Michigan University
2003
The exponential increase in global plastic usage has led to the emergence of nano- and microplastic (NMP) pollution as a pressing environmental issue due its implications for human other mammalian health. We have developed methodologies extract solid materials from tissue samples by saponification ultracentrifugation, allowing highly specific quantitative analysis plastics pyrolysis-gas chromatography mass spectrometry (Py-GC-MS). As benchmark, placenta were analyzed using fluorescence...
Rising global concentrations of environmental micro- and nanoplastics (MNPs) drive concerns for human exposure health outcomes. Applying pyrolysis gas chromatography-mass spectrometry (Py-GC/MS) methods to isolate quantify MNPs from samples, we compared MNP accumulation in kidneys, livers, brains. Autopsy samples the Office Medical Investigator Albuquerque, NM, collected 2016 2024, were digested Py-GC/MS analysis 12 polymers. Brains exhibited higher than liver or kidney samples. All organs...
Rising global concentrations of environmental microplastics and nanoplastics (MNPs) drive concerns for human exposure health outcomes. Complementary methods the robust detection tissue MNPs, including pyrolysis gas chromatography–mass spectrometry, attenuated total reflectance–Fourier transform infrared spectroscopy electron microscopy with energy-dispersive spectroscopy, confirm presence MNPs in kidney, liver brain. these organs primarily consist polyethylene, lesser but significant other...
There is significant controversy around whether chlorthalidone (CTD) superior to hydrochlorothiazide (HCTZ) in hypertension management. The objective of this analysis was evaluate the effects CTD compared with HCTZ on cardiovascular event (CVE) rates. We performed a retrospective observational cohort study from Multiple Risk Factor Intervention Trial data set National Heart, Lung, and Blood Institute. primary prevention trial where participants were men 35 57 years age enrolled followed...
Although the microbiota in proximal gastrointestinal (GI) tract have been implicated health and disease, much about these microbes remains understudied compared to those distal GI tract. This study characterized across multiple sites over time healthy individuals. As part of a pharmacokinetics oral mesalamine administration, healthy, fasted volunteers (
Abstract Microplastics represent an emerging environmental contaminant, with large gaps in our understanding of human health impacts. Furthermore, factors may modify the plastic chemistry, further altering toxic potency. Ultraviolet (UV) light is one such unavoidable factor for airborne microplastic particulates and a known modifier polystyrene surface chemistry. As experimental model, we aged commercially available microspheres 5 weeks UV radiation, then compared cellular responses A549...
Abstract Smoke from wildland fires has been shown to produce neuroinflammation in preclinical models, characterized by neural infiltrations of neutrophils and monocytes, as well altered neurovascular endothelial phenotypes. To address the longevity such outcomes, present study examined temporal dynamics metabolomics after inhalation exposures biomass-derived smoke. 2-month-old female C57BL/6 J mice were exposed wood smoke every other day for 2 weeks at an average exposure concentration 0.5...
Sacubitril was recently approved by the Food and Drug Administration for use in combination with valsartan treatment of patients heart failure reduced ejection fraction. As a prodrug, sacubitril must be metabolized (hydrolyzed) to its active metabolite sacubitrilat (LBQ657) exert intended therapeutic effects. Thus, understanding determinants activation will lead improvement pharmacotherapy. The objective this study identify enzyme(s) responsible sacubitril, determine impact genetic variation...
In vivo drug dissolution in the gastrointestinal (GI) tract is largely unmeasured. The purpose of this clinical study was to evaluate and systemic absorption BCS class IIa ibuprofen under fed fasted conditions by direct sampling stomach small intestinal luminal content. Expanding current knowledge will help establish physiologically relevant vitro models predictive dissolution. A multilumen GI catheter orally inserted into healthy human subjects. Subjects received a single oral dose (800 mg...
<b>Objective.</b> To qualitatively compare students' attitudes and perceptions regarding team-based learning (TBL) lecture. <b>Design.</b> Students were exposed to TBL lecture in an elective pharmacotherapeutics course a randomized, prospective, cross-over design. After completing the course, students provided their through written self-reflection narrative questions on end-of-course evaluation. Student responses reviewed using grounded theory coding method. <b>Assessment.</b> Students'...
Deleterious consequences of exposure to traffic emissions may derive from interactions between carbonaceous particulate matter (PM) and gaseous components in a manner that is dependent on the surface area or complexity particles. To determine validity this hypothesis, we examined pulmonary neurological inflammatory outcomes C57BL/6 apolipoprotein E knockout (ApoE−/−) male mice after acute chronic vehicle engine-derived matter, generated as ultrafine (UFP) fine (FP) sizes, with additional...
Abstract Utilizing a mobile laboratory located &gt;300 km away from wildfire smoke (WFS) sources, this study examined the systemic immune response profile, with focus on neuroinflammatory and neurometabolomic consequences, resulting inhalation exposure to naturally occurring wildfires in California, Arizona, Washington 2020. After 20-day (4 h/day) period stationed New Mexico, WFS-derived particulate matter (WFPM) resulted significant neuroinflammation while activity peripheral (lung,...
Background Wildland fires have become progressively more extensive over the past 30 years in United States, routinely generating smoke that deteriorates air quality for most of country. We explored neurometabolomic impact biomass-derived on older (18 months) female C57BL/6J mice, both acutely and after 10 weeks recovery from exposures. Methods Mice were exposed to wood (WS) 4 hours/day, every other day, 2 (7 exposures total) an average concentration 448 µg particulate matter (PM)/m 3 per...
Given that opioid misuse/abuse and overdose have reached epidemic proportions in the United States, expansion of naloxone access programs are desperately needed. The objective this study was to describe emerging trends rescue kit (NRK) prescription patterns by pharmacists New Mexico as an example a unique health care delivery system.The presents cross-sectional analysis data on NRK prescriptions who received pharmacist prescriptive authority certification since 2013. Data were obtained from...
Hawthorn, an herbal supplement, is currently being evaluated for the treatment of heart failure. The flavonoid components hawthorn may be responsible hawthorn's beneficial effects in However, these also affect P‐glycoprotein function and cause interactions with drugs that are substrates, such as digoxin, which used to treat Therefore, purpose this study was determine effect on digoxin pharmacokinetic parameters. A randomized, crossover trial 8 healthy volunteers performed evaluating 0.25 mg...
Background:The association of hyponatremia with cognitive impairment and mobility in heart failure (HF) patients is unknown.The purpose this study was to determine if associated as measured by simple, validated, time-sensitive tests. Material/Methods:This a prospective reduced preserved ejection fraction (HFrEF, HFpEF) seen outpatient HF clinics.Hyponatremia defined sodium level £136 mEq/L.Cognitive function using the Montreal Cognitive Assessment (MoCA) tool, Timed Up Go test (TUG-t)....