A5043596309- Heart Failure Treatment and Management
- Cardiac Health and Mental Health
- Dementia and Cognitive Impairment Research
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Mast cells and histamine
- Extracellular vesicles in disease
- Stroke Rehabilitation and Recovery
- Heart Rate Variability and Autonomic Control
- Emergency and Acute Care Studies
- Immune cells in cancer
- Cardiovascular and exercise physiology
- Cognitive Functions and Memory
- Cardiovascular Health and Risk Factors
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Blood Pressure and Hypertension Studies
- PI3K/AKT/mTOR signaling in cancer
- Food Allergy and Anaphylaxis Research
- BRCA gene mutations in cancer
- Mitochondrial Function and Pathology
- GDF15 and Related Biomarkers
- Phagocytosis and Immune Regulation
- Mindfulness and Compassion Interventions
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Apelin-related biomedical research
Indiana University – Purdue University Indianapolis
2015-2024
National Institutes of Health
2002-2024
National Institute of Neurological Disorders and Stroke
2023
National Institute of Nursing Research
2013-2023
University of Michigan
2012-2023
National Institute on Aging
2023
Jazan University
2022
Indiana University
2021-2022
The Ohio State University
1992-2022
East Carolina University
2021
Mendelian analysis of disorders immune regulation can provide insight into molecular pathways associated with host defense and tolerance.We identified three families a dominantly inherited complex cold-induced urticaria, antibody deficiency, susceptibility to infection autoimmunity. Immunophenotyping methods included flow cytometry, serum immunoglobulins autoantibodies, lymphocyte stimulation, enzymatic assays. Genetic studies linkage analysis, targeted Sanger sequencing, next-generation...
Laulimalide is a cytotoxic natural product that stabilizes microtubules. The compound enhances tubulin assembly, and laulimalide quantitatively comparable to paclitaxel in its effects on the reaction. also active P-glycoprotein overexpressing cells, while isolaulimalide, congener without drug's epoxide moiety, was reported have negligible biochemical activity [Mooberry et al. (1999) Cancer Res. 59, 653−660]. We report here binds at site polymer distinct from taxoid site. found laulimalide,...
The family caregivers of patients with heart failure (HF) report burden and poor quality life, but little is known about changes in their perceptions over time.The aims this study were (1) to evaluate caregiver (perceived time spent difficulty caregiving tasks), perceived control, depressive symptoms, anxiety, life changes, physical emotional health-related life; (2) determine differences between low HF symptoms (New York Heart Association class I II) high III IV); (3) the estimate...
Transforming growth factor-beta (TGFβ) is an enigmatic protein with various roles in healthy tissue homeostasis/development as well the development or progression of cancer, wound healing, fibrotic disorders, and immune modulation, to name a few. As TGFβ causal fibroproliferative disorders featuring localized systemic tissue/organ fibrosis activated stroma observed malignancies, characterizing pathways players mediating its action fundamental. In current study, we found that induces...
Abstract Background Immunosuppression in glioblastoma (GBM) is an obstacle to effective immunotherapy. GBM-derived immunosuppressive monocytes are central this. Programmed cell death ligand 1 (PD-L1) immune checkpoint molecule, expressed by GBM cells and extracellular vesicles (EVs). We sought determine the role of EV-associated PD-L1 formation monocytes. Methods Monocytes collected from healthy donors were conditioned with EVs induce monocytes, which quantified via flow cytometry....
Abstract We report the cloning and sequencing of 18 mutant alleles benA , β‐tubulin gene Aspergillus nidulans that confer resistance to benzimidazole antifungal, antimicrotubule compounds benomyl, carbendazim, nocodazole, thia‐bendazole. In 12 cases, amino acid 6 was changed from histidine tyrosine or leucine. four 198 glutamic aspartic acid, glutamine, lysine. two 200 altered phenylalanine tyrosine. These data, along with previous data indicating 165 is involved in binding R2 group these...
Mast cells, activated by Ag via FcεRI, release an array of proinflammatory mediators that contribute to allergic disorders, such as asthma and anaphylaxis. The KIT ligand, stem cell factor (SCF), is critical for mast expansion, differentiation, survival, under acute conditions, it enhances activation. However, extended SCF exposure in vivo conversely protects against fatal Ag-mediated In investigating this dichotomy, we identified a novel mode regulation the activation phenotype through...
TGF-β plays a central role in the pathogenesis of fibroproliferative disorders. Defining exact underlying molecular basis is therefore critical for development viable therapeutic strategies. Here, we show that expression facilitative glucose transporter 1 (GLUT1) induced by fibroblast lines and primary cells required profibrotic effects TGF-β. In addition, enhanced GLUT1 observed fibrotic areas lungs both patients with idiopathic pulmonary fibrosis mice are subjected to fibrosis-inducing...
Evidence is provided that the fibroproliferative actions of TGF-β are dependent on a metabolic adaptation sustains pathologic growth. Specifically, profibrotic signaling shown to require fatty acid synthase (FASN), an essential anabolic enzyme responsible for de novo synthesis acids. With use pharmacologic and genetic approaches, we show TGF-β-stimulated FASN expression independent Smad2/ 3 mediated via mammalian target rapamycin complex 1. In absence activity or protein, -driven fibrogenic...
IL-33 is elevated in afflicted tissues of patients with mast cell (MC)-dependent chronic allergic diseases. Based on its acute effects mouse MCs, thought to play a role the pathogenesis disease through MC activation. However, manifestations prolonged exposure human function, which best reflect conditions associated disease, are unknown. In this study, we found that long-term and MCs results substantial reduction activation response Ag. This required >72 h for onset 1-2 wk reversion following...
Theories of pain have been developed in several patient populations, but none currently exist for heart failure (HF) that include contributing factors and associated outcomes. We a situation-specific theory HF by adapting the biopsychosocial model pain. Existing theoretical empirical literature samples was utilized to construct new theory. Components, factors, outcomes are presented Areas need additional research emphasized, strengths limitations discussed. This could provide foundation...
Background Incidence of cognitive impairment and its consequences have not been fully examined in heart failure (HF). Objective The aim this study was to examine associations HF with decline, frequencies risks of, time-to-develop mild (MCI) or dementia during 15-year follow-up. Methods For retrospective cohort study, data were retrieved from the National Alzheimer's Coordinating Center. Cognitive decline assessed using Uniform Data Set neuropsychological battery. Development MCI clinically...
Peroxidation of cardiolipin in mitochondria is essential for the execution apoptosis. We suggested that integration oleic acid into generates non-oxidizable species hence protects cells against synthesized mitochondria-targeted triphenylphosphonium ester. Using lipidomics analysis we found pretreatment mouse embryonic with ester resulted decreased contents polyunsaturated cardiolipins and elevation its containing residues. This caused suppression apoptosis induced by actinomycin D. Triacsin...
In heart failure (HF), attention may be decreased because of lowered cerebral blood flow and increased attentional demands needed for self-care.Guided by the Attention Restoration Theory, objective was to test efficacy natural restorative environment (NRE) intervention on improving mood among HF patients healthy adults.A randomized crossover pilot study conducted 20 an age- education-matched comparison group adults NRE compared with active control intervention. Neuropsychological tests were...
Carriers of breast cancer gene (BRCA) mutations are asked to communicate genetic test results their biological relatives increase awareness risk and promote use services. This process is highly variable from family family. Interventions that support communication results, coping, offer decision in families harboring a pathogenic variant may contribute effective management hereditary cancer.The aim this paper was describe the development Family Gene Toolkit, Web-based intervention targeting...