A5000267315- Extracellular vesicles in disease
- Genomics and Phylogenetic Studies
- Immune cells in cancer
- Molecular Biology Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Cell Image Analysis Techniques
- RNA and protein synthesis mechanisms
University of Wisconsin–Madison
2023
Mayo Clinic
2020
Mayo Clinic in Arizona
2019
Abstract Background Immunosuppression in glioblastoma (GBM) is an obstacle to effective immunotherapy. GBM-derived immunosuppressive monocytes are central this. Programmed cell death ligand 1 (PD-L1) immune checkpoint molecule, expressed by GBM cells and extracellular vesicles (EVs). We sought determine the role of EV-associated PD-L1 formation monocytes. Methods Monocytes collected from healthy donors were conditioned with EVs induce monocytes, which quantified via flow cytometry....
As exemplified by the global response to SARS-CoV-2 pandemic, whole-genome sequencing played an important role in monitoring evolution of novel viral variants and provided guidance on potential antiviral treatments. The recent rapid extensive introduction spread highly pathogenic avian influenza virus Europe, North America, elsewhere raises need for similarly aid appropriate mitigation activities. To facilitate this objective, we investigate a next-generation platform that uses portable...
As exemplified by the global response to SARS-CoV-2 pandemic, whole genome sequencing played an important role in monitoring evolution of novel viral variants and provided guidance on potential antiviral treatments. The recent rapid extensive introduction spread highly pathogenic avian influenza virus Europe, North America elsewhere raises need for similarly aid appropriate mitigation activities. To facilitate this objective, we investigated a next generation platform that uses portable...
Abstract Glioblastoma (GBM) is the most common and lethal primary brain tumor, novel therapeutic strategies that make a substantial impact on outcomes are sorely needed. Immunotherapies have shown great promise in treatment of number cancers recent year, concerted effort being made to apply these paradigms GBM. However, many GBM patients exhibit profound immunosuppression, likely limiting efficacy such approaches. The mechanisms this immunosuppression poorly understood, but tumor-derived...