A5084136765- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacological Receptor Mechanisms and Effects
- Immune Response and Inflammation
- Cancer, Stress, Anesthesia, and Immune Response
- Nerve injury and regeneration
- Neurotransmitter Receptor Influence on Behavior
- Lipid Membrane Structure and Behavior
- Anesthesia and Sedative Agents
- S100 Proteins and Annexins
- Botulinum Toxin and Related Neurological Disorders
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Neurotoxicity Research
- Cell Adhesion Molecules Research
- NF-κB Signaling Pathways
- Anesthesia and Pain Management
- Traumatic Brain Injury Research
- Wnt/β-catenin signaling in development and cancer
University at Buffalo, State University of New York
2011-2024
Jacobs (United States)
2019-2024
New York University
2018
State University of New York
2003
University of Rochester
1996-1999
University of Rochester Medical Center
1997
Neuropathic pain is a chronic syndrome that arises from nerve injury. Current treatments only offer limited relief, clearly indicating the need for more effective therapeutic strategies. Previously, we demonstrated proinflammatory tumor necrosis factor-alpha (TNF) key mediator of neuropathic pathogenesis; TNF elevated at sites neuronal injury, in spinal cord, and supraspinally during initial development pain. The inhibition action along pathways outside higher brain centers results transient...
Summary Increasing only the expression of pleiotropic cytokine tumor necrosis factor–alpha exclusively in hippocampus naïve rats induces peripheral hypersensitivity to thermal and mechanical stimulation reminiscent chronic pain behaviors. The manifestation chronic, neuropathic includes elevated levels (TNF). Previously, we have shown that hippocampus, an area brain most notable for its role learning memory formation, plays a fundamental sensation. Using animal model pain, demonstrated...
Aim: Gold nanorods (GNRs), cellular imaging nanoprobes, have been used for drug delivery therapy to immunologically privileged regions in the brain. We demonstrate that nanoplexes formed by electrostatic binding between negatively charged RNA and positively GNRs, silence expression of target housekeeping gene, glyceraldehyde 3-phosphate dehydrogenase (GAPDH) within CA1 hippocampal region rat brain, without showing cytotoxicity. Materials & Methods: Fluorescence with siRNACy3GAPDH dark-field...
<h3>Background and Objectives</h3> Evidence implicates the pleiotropic cytokine tumor necrosis factor alpha (TNFα) in pathogenesis of persistent pain. The present study employs a chronic constriction injury (CCI) model neuropathic pain to examine TNFα production central nervous system (CNS) periphery this model. <h3>Methods</h3> CCI-induced hyperalgesia is assessed by measuring nociceptive threshold using hot-plate test. development correlated levels assessing: bioactive homogenates sciatic...
There is increasing recognition of the involvement immune signaling molecule, tumor necrosis factor (TNF), in pathophysiology stroke and chronic brain dysfunction. TNF plays an important role both modulating synaptic function pathogenesis neuropathic pain. Etanercept a recombinant therapeutic that neutralizes pathologic levels TNF. Brain imaging has demonstrated intracerebral microglial activation neuroinflammation following other forms acute injury. Activated microglia release TNF, which...
Schizophrenia (SZ) is a neurodevelopmental genetic disorder in which maternal immune activation (MIA) and increased tumor necrosis factor-α (TNF-α) may contribute. Previous studies using iPSC-derived cerebral organoids neuronal cells demonstrated developmental malformation transcriptional dysregulations, including TNF receptors their signaling genes, common to SZ patients with diverse backgrounds. In the present study, we examined significance of receptor dysregulations by transiently...
The present study documents a role for brain-derived tumor necrosis factor-α (TNF) in the mechanism of action antidepressant drug desmethylimipramine (desipramine). To establish this role, field stimulation and superfusion rat hippocampal slices was employed to investigate regulation norepinephrine (NE) release by TNF. Chronic desipramine administration transforms TNF-mediated inhibition NE facilitation, dependent upon α<sub>2</sub>-adrenergic receptor activation. i.c.v. microinfusion...
The analgesic properties of α2-agonists are well known. In experimental models, tumor necrosis factor (TNF)-α regulates adrenergic responses in the brain. Constitutive TNF-α, brain regions involved pain perception, is decreased after administration clonidine. We investigated patients undergoing lower-extremity revascularization. Seven were treated with clonidine 0.2 mg per os (low), and three received 0.4 (high) before surgery. Eight placebo served as controls. Continuous spinal anesthesia...
Chemotherapy-induced peripheral neurotoxicity is a common dose-limiting side effect of several cancer chemotherapeutic agents, and no effective therapies exist. Here we constructed systems pharmacology model intracellular signaling in neurons to identify novel drug targets for preventing neuropathy associated with proteasome inhibitors. Model predictions suggested the combinatorial inhibition TNFα, NMDA receptors, reactive oxygen species should prevent inhibitor-induced neuronal apoptosis....
Background This study aimed to describe the neurological improvements in a patient with severe long COVID brain dysfunction following perispinal etanercept administration. Perispinal administration of etanercept, novel method designed enhance its delivery via carriage cerebrospinal venous system, has previously been shown reduce chronic after stroke. Etanercept is recombinant biologic that capable ameliorating two components neuroinflammation: microglial activation and excess bioactivity...
Alpha2 adrenergic agonists have long been employed as analgesics and to sedate patients undergoing surgical procedures. In addition, their therapeutic response synergizes that elicited by opioids. Although this is well known, the role of alpha2 agonists, such clonidine, during various painful procedures remains be elucidated. The goal our study was evaluate effects intrathecal administration clonidine on postoperative pain control time extubation in coronary artery bypass...