A5088597690- Cancer Treatment and Pharmacology
- Glioma Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Multiple Myeloma Research and Treatments
- Renal function and acid-base balance
- Respiratory Support and Mechanisms
- Microtubule and mitosis dynamics
- High Altitude and Hypoxia
- Pain Mechanisms and Treatments
- Cancer-related cognitive impairment studies
- Peripheral Neuropathies and Disorders
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Eicosanoids and Hypertension Pharmacology
- Brain Metastases and Treatment
- Metabolism and Genetic Disorders
- Plant-based Medicinal Research
- Chemotherapy-related skin toxicity
- Medical Imaging Techniques and Applications
- Neurological Disorders and Treatments
- Mitochondrial Function and Pathology
- Systemic Sclerosis and Related Diseases
- Radiation Dose and Imaging
- Antibiotics Pharmacokinetics and Efficacy
- Mesoporous Materials and Catalysis
University of Milano-Bicocca
2018-2024
University of Milan
2024
Ospedale Regionale di Bellinzona e Valli
2020
Ente Ospedaliero Cantonale
2020
Fondazione Audiologica Varese
2017
Agostino Gemelli University Polyclinic
1995
IRCCS Policlinico San Donato
1992
Chemotherapy-induced peripheral neurotoxicity (CIPN) is a severe adverse effect in patients receiving antitumor agents, and no effective treatment available. Although the mechanisms responsible for development of CIPN are poorly understood, recent findings make neuroinflammation an attractive target to be investigated, particularly when neuropathic pain prominent feature such as after bortezomib administration. The aim our study was evaluate intravenous immunoglobulins (IVIg) delivery...
Significance Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating “dying back” featuring distal-to-proximal nerve degeneration seen in cancer patients undergoing chemotherapy. The pathogenenic mechanisms of CIPN are largely unknown. We report that sensory neurons, the CIPN-inducing drug bortezomib caused axonopathy and disrupted mitochondria motility by increasing delta 2 tubulin (D2), only irreversible posttranslational modification marker hyper-stable microtubules. These...
Oxaliplatin (OHP) is an antineoplastic compound able to induce peripheral neurotoxicity. Oxidative stress has been suggested be a key factor in the development of OHP-related Mangafodipir, contrast agent possessing mitochondrial superoxide dismutase (MnSOD)-mimetic activity, tested as cytoprotector chemotherapy-induced neurotoxicity (CIPN). Calmangafodipir (PledOx®) even better therapeutic activity. We investigated BALB/c mouse model CIPN and effects pre-treatment calmangafodipir (2.5, 5, or...
The onset of chemotherapy-induced peripheral neurotoxicity (CIPN) is a leading cause the dose reduction or discontinuation cancer treatment due to sensory symptoms. Paclitaxel (PTX) can painful neuropathy, with negative impact on survivors’ quality life. While recent studies have shown that neuroinflammation involved in PTX-induced (PIPN), pathophysiology this disabling side effect remains largely unclear and no effective therapies are available. Therefore, here we investigated effects human...
Chemotherapy-induced peripheral neurotoxicity is a common dose-limiting side effect of several cancer chemotherapeutic agents, and no effective therapies exist. Here we constructed systems pharmacology model intracellular signaling in neurons to identify novel drug targets for preventing neuropathy associated with proteasome inhibitors. Model predictions suggested the combinatorial inhibition TNFα, NMDA receptors, reactive oxygen species should prevent inhibitor-induced neuronal apoptosis....
Peripheral neurotoxicity is a dose-limiting adverse reaction of primary frontline chemotherapeutic agents, including vincristine. Neuropathy can be so disabling that patients drop out potentially curative therapy, negatively impacting cancer prognosis. The hallmark vincristine axonopathy, yet its underpinning mechanisms remain uncertain. We developed comprehensive drug discovery platform to identify neuroprotective agents against vincristine-induced neurotoxicity. Among the hits identified,...
Human respiratory syncytial virus (RSV) is the leading cause of acute lower tract infection among infants and young children worldwide, with seasonal peaks in January February. This study aimed to characterize RSV samples from a pediatric cohort 2021-2022 season Italy. In total, 104 were collected patients attending "Vittore Buzzi" Children's Hospital Milan, Italy season. RT-PCR next-generation sequencing used discriminate subgroups obtain whole genomes. Maximum likelihood Bayesian...
Chemotherapy-induced peripheral neurotoxicity represents one of the most relevant dose-limiting side effects that can affect cancer patients treated with common antineoplastic agents. Since severity often leads to dose reduction or early cessation chemotherapy, investigation molecular mechanisms underlying chemotherapy-induced is an urgent clinical need in order better understand its physiopathology and find effective strategies for neuroprotection. Several vivo preclinical models have been...
Peripheral neuropathies (PNs) are a type of common disease that hampers the quality life affected people. Treatment, in most cases, is just symptomatic and often ineffective. To improve drug discovery this field, preclinical evidence warranted. In vivo rodent models allow multiparametric approach to test new therapeutic strategies, since they can pathogenetic morphological studies different from clinical setting. However, human readouts warranted promptly translate data bench bedside. A...
Transplantation of pancreatic islets is an intriguing new therapeutic option to face the worldwide spread problem Type-I diabetes. Currently, its clinical use limited by several problems, mainly based on high number required restore normoglycaemia and low survival transplanted tissue. A promising attempt overcome limits such approach was represented Mesenchymal Stem Cells (MSC). Despite encouraging results obtained with murine-derived MSC, little still known about their protective...
Oxaliplatin-induced peripheral neuropathy is characterized by an acute hyperexcitability syndrome triggered/exacerbated cold. The mechanisms underlying oxaliplatin-induced are unclear, but the alteration of ion channel expression and activity plays a well-recognized central role. Recently, we found that oxaliplatin leads to cytosolic acidification in dorsal root ganglion (DRG) neurons. Here, investigated early impact on proton-sensitive TREK potassium channels. Following 6-h treatment, both...
<title>Abstract</title> Peripheral neurotoxicity is a dose-limiting adverse reaction of primary frontline chemotherapeutic agents, including vincristine. Neuropathy can be so disabling that patients drop out potentially curative therapy, negatively impacting cancer prognosis. The hallmark vincristine axonopathy, yet its underpinning mechanisms remain uncertain. We developed comprehensive drug discovery platform to identify neuroprotective agents against vincristine-induced neurotoxicity....
The direct contact of Mesenchymal Stem Cells (MSCs) with Dorsal Root Ganglia sensory neurons is pivotal to prolong the neuronal survival and support their maturation (1). Here we further investigated mechanisms underlying this contact-mediated positive effect, focusing our attention on possible interaction between MSCs neurons, in particular gap junction formation. We set up co-cultures after 30 days analyzed them. electron microscopy analysis evidenced presence junctions only co-cultures....