A5039726944- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Advanced X-ray and CT Imaging
- Particle Detector Development and Performance
- Radiation Dose and Imaging
- Radiation Detection and Scintillator Technologies
- Medical Imaging Techniques and Applications
- Astrophysics and Cosmic Phenomena
- Gamma-ray bursts and supernovae
- Radiation Effects in Electronics
- Digital Radiography and Breast Imaging
- Field-Flow Fractionation Techniques
- Particle Accelerators and Free-Electron Lasers
- Dark Matter and Cosmic Phenomena
- Nanoparticle-Based Drug Delivery
- Nuclear Physics and Applications
- Prostate Cancer Diagnosis and Treatment
- Gas Dynamics and Kinetic Theory
- Radiation Shielding Materials Analysis
- Radiomics and Machine Learning in Medical Imaging
- Boron Compounds in Chemistry
- Graphene and Nanomaterials Applications
- Lung Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Advances in Oncology and Radiotherapy
Institute of Oncology Research
2023
Istituto Imaging della Svizzera Italiana
2020-2023
Ente Ospedaliero Cantonale
2018-2022
Ospedale Regionale di Bellinzona e Valli
2020
Paul Scherrer Institute
2011-2017
University of California, Los Angeles
2015
University of Haifa
2015
The University of Adelaide
2015
Loma Linda University
2015
ETH Zurich
2013
Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build next generation instrument, factor 5-10 improvement sensitivity 100 GeV 10 TeV range extension energies well below above TeV. will consist two arrays (one north, one south) for full sky coverage be operated as open observatory....
Clinically relevant intensity modulated proton therapy (IMPT) treatment plans were measured in a newly developed anthropomorphic phantom (i) to assess plan accuracy the presence of high heterogeneity and (ii) measure robustness case uncertainties (range spatial). The new consists five different tissue substitute materials simulating types was cut into sagittal planes so as facilitate verification co-planar fields. GafChromic films positioned phantom, 3D-IMPT distal edge tracking (DET)...
The 'worst case scenario' (also known as the minimax approach in optimization terms) is a common to model effect of delivery uncertainties proton treatment planning. Using 'dose-error-bar distribution' previously reported by our group an example, we have investigated more detail one underlying assumptions this method. That is, dose distributions calculated for limited number worst patient positioning scenarios (i.e. shifts sampled on spherical surface) represent that can occur during under...
To investigate the effect of metal implants in proton radiotherapy, dose distributions different, clinically relevant treatment plans have been measured an anthropomorphic phantom and compared to planning predictions. The phantom, which is sliced into four segments cranio-caudal direction, composed tissue equivalent materials contains a titanium implant vertebral body cervical region. GafChromic® films were laid between different measure 2D delivered dose. Three four-field then applied:...
A split feasibility formulation for the inverse problem of intensity-modulated radiation therapy (IMRT) treatment planning with dose-volume constraints (DVCs) included in algorithm is presented.It involves a new type sparsity constraint that enables inclusion percentage-violation model and its handling by continuous (as opposed to integer) methods.We propose an iterative algorithmic framework solving such applying feasibility-seeking CQ-algorithm Byrne combined automatic relaxation method...
Treatment planning for particle therapy is currently an active field of research due uncertainty in how to modify physical dose order create a uniform biological response the target. A novel treatment plan optimization strategy based on measurable nanodosimetric quantities rather than biophysical models proposed this work. Simplified proton and carbon plans were simulated water phantom investigate feasibility. Track structures mixed radiation produced at different depths target volume with...
The track structure of ionizing radiation predominantly determines the biological effects after irradiation. A new detector to register 3D segments in low pressure gas was proposed a previous work. device combines operational principle thick electron multipliers (THGEM), working reverse polarity, and resistive plate chambers. In this work, further developed. Optimization THGEM thickness, hole pitch cathode resistivity were studied. prototype built tested with microbeam providing different...
The spatial distribution of radiation-induced ionisations in sub-cellular structures plays an important role the initial formation radiation damage to biological tissues. Using nanodosimetry approach, physical characteristics track structure can be measured and correlated DNA damage. In this work, a novel nanodosimeter is presented, which detects positive ions produced by interacting with gas-sensitive volume order obtain high resolution image structure. characterisation detector prototype...
Aim. The purpose of this planning report is to compare dosimetric results deep inspiration breath hold (DIBH) and free breathing (FB) set up in patients with synchronous bilateral breast cancer (SBBC) treated adjuvant radiotherapy. Material methods. Fourteen early stage were conservative surgery. Bilateral treatment volume (PTV) organs at risk (OARs) delineated for DIBH FB datasets on the computed tomography (CT). Volumetric modulated arc therapy (VMAT/RapidArc ®) plans generated two...
Purpose: To investigate the applicability of feasibility‐seeking cyclic orthogonal projections to field intensity modulated proton therapy (IMPT) inverse planning. Feasibility constraints only, as opposed optimization a merit function, is less demanding algorithmically and holds promise parallel computations capability with non‐cyclic algorithms such string‐averaging or block‐iterative strategies. Methods: A virtual 2D geometry was designed containing C‐shaped planning target volume (PTV)...
Using optimal settings for x-ray scans is crucial obtaining three-dimensional images of high quality while keeping the patient dose low. Our work compares and image (IQ) three intraoperative imaging systems [O-arm cone-beam computed tomography (CBCT), ClarifEye C-arm CBCT, Airo tomography] used spinal surgery.
To evaluate the performance of low dose cone beam CT (CBCT) acquisition protocols for image-guided radiotherapy prostate cancer.
Abstract Introduction: The RapidPlan is a radiotherapy planning tool that uses dataset of approved plans to predict the dose distribution and automatically generates dose–volume constraints for optimisation new plan. This study compares three strategies model building treatment prostate cancer with 10-MV photon beam. Methods: Three models were compared: Model 6X , Model10X Model6Xrefined . Model6X already used in our department was trained on based 6-MV beam manually optimised by an...