A5036702560- Breast Cancer Treatment Studies
- Advanced Radiotherapy Techniques
- Breast Lesions and Carcinomas
- Advances in Oncology and Radiotherapy
- Global Cancer Incidence and Screening
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Cancer Studies
- Brain Metastases and Treatment
- Effects of Radiation Exposure
- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Lung Cancer Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Nonmelanoma Skin Cancer Studies
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Radiation Therapy and Dosimetry
- Genetic factors in colorectal cancer
- Sarcoma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Chemotherapy-induced cardiotoxicity and mitigation
- Glioma Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
Ente Ospedaliero Cantonale
2022-2025
Ospedale Sant'Anna
2015-2024
Institute of Oncology Research
2010-2023
European Organisation for Research and Treatment of Cancer
2022
Ospedale Regionale di Bellinzona e Valli
2015-2019
Università della Svizzera italiana
2018
European Organisation for Research and Treatment of Cancer
2014
Ospedale Santa Chiara
2000
The effect of internal mammary and medial supraclavicular lymph-node irradiation (regional nodal irradiation) added to whole-breast or thoracic-wall after surgery on survival among women with early-stage breast cancer is unknown.We randomly assigned who had a centrally medially located primary tumor, irrespective axillary involvement, an externally tumor involvement undergo either in addition regional (nodal-irradiation group) alone (control group). end point was overall survival. Secondary...
The results in terms of side effects vary among the published accelerated partial-breast irradiation (APBI) studies. Here, we report 5-year for cosmetic outcomes and toxicity IRMA trial.We ran this randomized phase III trial 35 centers. Women with stage I-IIA breast cancer treated breast-conserving surgery, age ≥ 49 years, were randomly assigned 1:1 to receive either whole-breast (WBI) or external beam radiation therapy APBI (38.5 Gy/10 fraction twice daily). Patients investigators not...
Uncertainty about the benefit-risk ratio of regional lymph node irradiation led to varying clinical protocols. We investigated long-term late side effects after internal mammary and medial supraclavicular (IM-MS) improve shared decision making.The multicenter European Organization for Research Treatment Cancer trial (ClinicalTrials.gov, NCT00002851) randomly assigned stage I-III breast cancer patients with involved axillary nodes and/or a medially located primary tumor. analyzed both...
Abstract Background To report about initial clinical experience in radiation treatment of carcinoma prostate with volumetric modulated arcs the RapidArc (RA) technology. Methods Forty-five patients a median age 72 ± 3, affected by (T1c: 22 patients, T2a-b: 17 T3a-b: 6 patients. N0: 43 N1-Nx: 2 all M0), PSA 10.0 3.0 ng/mL, were treated feasibility study. All single arc using 6MV photons. Dose prescription ranged between 76 (7 patients) and 78 Gy (38 2Gy/fraction. Plan quality was assessed...
Circulating tumor DNA (ctDNA) correlates with the response to therapy in different types of cancer. However, patients locally advanced rectal cancer (LARC), little is known about how ctDNA levels change neoadjuvant chemoradiation (Na-ChRT) and they correlate treatment response. This work aimed explore value serial liquid biopsies monitoring after Na-ChRT hypothesis that this could become a reliable biomarker identify complete response, candidates for non-operative management.Twenty-five...
The aim of our study is to determine whether deep inspiration breath hold (DIBH) effective for reducing exposure the heart, left coronary artery (LAD) and both lungs in right breast radiotherapy.We have analyzed 10 consecutive patients with right-sided cancer (BC), simulated during free breathing (FB) DIBH modality. For all we contoured PTV organs at risk (right lungs, LAD) on CT scans (FB DIBH). Finally, 5 were treated IMRT VMAT techniques.All able end treatments modalities regardless...
Aim. The purpose of this planning report is to compare dosimetric results deep inspiration breath hold (DIBH) and free breathing (FB) set up in patients with synchronous bilateral breast cancer (SBBC) treated adjuvant radiotherapy. Material methods. Fourteen early stage were conservative surgery. Bilateral treatment volume (PTV) organs at risk (OARs) delineated for DIBH FB datasets on the computed tomography (CT). Volumetric modulated arc therapy (VMAT/RapidArc ®) plans generated two...
To analyze the impact of adjuvant radiotherapy (RT) on ipsilateral breast recurrence (IBR) and overall survival (OS) in patients older than 69 years with early-stage cancer.From January 2007 to June 2015, we analyzed retrospectively 137 women estrogen receptor-positive T1-2 invasive cancer, negative axillary lymph nodes, dividing them into 2 subgroups: 70 79 years.After a median follow-up 43.2 months, 3-year IBR-free treated surgery plus RT was 98.8% 92.1% alone, significant difference (p =...
The incidence of breast cancer is rising worldwide. Recent advances in systemic and local treatments have significantly improved survival rates patients having early cancer. In the last decade, great attention has been paid to prevention detection cardiotoxicity induced by treatments. Systemic therapy-related cardiac toxicities extensively studied. Radiotherapy, an essential component treatment, can also increase risk heart diseases. Consequently, it important balance expected benefits...