A5040387215- Pulmonary Hypertension Research and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Vascular Anomalies and Treatments
- Cardiac pacing and defibrillation studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiovascular Effects of Exercise
- Cardiovascular Issues in Pregnancy
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac tumors and thrombi
- Global Cancer Incidence and Screening
- Apelin-related biomedical research
- Cardiomyopathy and Myosin Studies
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Anesthesia and Sedative Agents
- Cardiac Structural Anomalies and Repair
- Congenital Heart Disease Studies
- Economic and Financial Impacts of Cancer
- Metabolism, Diabetes, and Cancer
- Transplantation: Methods and Outcomes
- Hormonal Regulation and Hypertension
- Colorectal Cancer Screening and Detection
Policlinico San Matteo Fondazione
2017-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2001-2025
Regione del Veneto
2024
AULSS 2 Marca Trevigiana
2020-2024
Hospital Sant Joan de Déu Barcelona
2023
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2023
Humanitas Mater Domini
2023
University of Pavia
2023
University of Bologna
2022
Università Campus Bio-Medico
2021
Rationale: An initial oral combination of drugs is being recommended in pulmonary arterial hypertension (PAH), but the effects this approach on risk reduction and vascular resistance (PVR) are not known.Objectives: To test hypothesis that a low-risk status would be determined by PVR patients with PAH treated upfront drugs.Methods: The study enrolled 181 treatment-naive (81% idiopathic) follow-up right heart catheterization at 6 months (interquartile range, 144–363 d) after endothelin...
Background A novel approach to derive prognostic information from echocardiography in pulmonary arterial hypertension (PAH) is define a phenotype of right heart function combining standard echocardiographic parameters which describe ventricular pump and systemic venous congestion. We tested the hypothesis that combination advanced strain imaging could yield high accuracy. Methods This was prospective observational study with single centre derivation cohort second validation cohort. The...
The correlation between myocardial injury and clinical outcome in COVID-19 patients is gaining attention the literature. aim of present study was to evaluate role cardiac involvement respiratory failure a cohort hospitalized an academic hospital Lombardy, one most affected Italian (and worldwide) regions by epidemic. included 405 consecutive with confirmed admitted medical ward from February 25th March 31st, 2020. Follow-up surviving ended either at discharge or July 30th, Myocardial defined...
Abstract Introduction Regular screening for pulmonary hypertension (PH) is recommended in patients with systemic sclerosis (SSc) the early detection and treatment of arterial (PAH). Whether Doppler echocardiography may predict subsequent development PH still unknown. In this context, there growing awareness potential importance right atrial (RA) function reflecting an initial overload heart due to hypertensive state circulation a matter considerable interest. Aim We tested hypothesis that RA...
Aim: Significant tricuspid regurgitation (TR) may be a confounding factor when assessing right ventricular (RV) function with imaging techniques. Global myocardial work (GMW) has been proposed as non-invasive surrogate of RV pressure–volume loops, and it might provide more accurate evaluation performance than standard echocardiographic parameters, accounting for both afterload efficiency. The aim this study was to assess the relationship between GMW hemodynamic indices prognostic...
Demographic characteristics of pulmonary arterial hypertension (PAH) patients have changed over time, but the effects cardiovascular risk factors on status and vascular resistance (PVR) reduction with initial oral combination therapy are not known. Therefore, we tested relevance comorbidities in this setting.The study enrolled 181 treatment-naive PAH a 6-month (IQR 144-363 days) right heart catheterisation assessment after therapy.Group A included 96 (53.0%) without cardiac comorbidities;...
Objective We investigated whether there are differences in cancer incidence by geographical area of origin North-eastern Italy. Methods selected all incident cases recorded the Veneto Tumour Registry period 2015-2019. Subjects were classified, based on country birth, six areas (Italy, Highly Developed Countries-HDC, Eastern Europe, Asia, Africa, South-central America). Age-standardized rates and rate ratio (IRR) calculated, for sites colorectal, liver, breast cervical separately. Results...
Aims: Oxidative protein folding in the luminal compartment of endoplasmic reticulum (ER) is thought to be accompanied by generation H2O2, as side-product disulfide bond formation. We aimed examine role H2O2 produced lumen, which on one hand can lead redox imbalance and hence contribute ER stress caused overproduction secretory proteins; other hand, an excellent electron acceptor, might serve additional pro-oxidant physiological oxidative folding. Results: Stimulation production hepatic...
The coronavirus disease 2019 (COVID-19) outbreak has led to significant restrictions on routine medical care. We conducted a multicentre nationwide survey of patients with pulmonary arterial hypertension (PAH) determine the consequences governance measures PAH management and risk poor outcome in COVID-19.The present study, which included 25 Italian centres, considered demographic data, number in-person visits, 6-min walk echocardiographic test results, brain natriuretic peptide/N-terminal...
Initial combination therapy with ambrisentan and tadalafil (upfront therapy) offers clinical benefits in pulmonary arterial hypertension (PAH) reduces the risk of failure compared monotherapy naïve patients. The aim study is to assess efficacy a 12-month upfront improving haemodynamics incident PAH patients.This multicentre retrospective analysis real-world Italian data 56 patients newly diagnosed PAH. Clinical evaluations, including demographics, medical history, WHO functional class, 6-min...
The aim of this study was to evaluate the prevalence iron depletion in a prevalent population patients with pulmonary arterial hypertension (PAH) and gain preliminary insights on possibility its treatment oral drugs.Iron status determined 31 consecutive idiopathic PAH. Iron defined as serum <10 mmol/L decreased transferrin saturation irrespective coexistence anaemia. Patients underwent laboratory examinations, 6-min walking test echocardiography same day. A subgroup depleted received one...
Population-based cancer registration methods are subject to internationally-established rules. To ensure efficient and effective case recording, population-based registries widely adopt digital processing (DP) methods. At the Veneto Tumor Registry (RTV), about 50% of all digitally-identified (putative) cases further profiled by means registrars' assessments (RAs). Taking these RAs for reference, present study examines how well registry's DP performs. A series 1,801 incident prevalent cancers...