A5102922926- Pulmonary Hypertension Research and Treatments
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Cardiac Valve Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Cardiac Structural Anomalies and Repair
- Atrial Fibrillation Management and Outcomes
- Takotsubo Cardiomyopathy and Associated Phenomena
- Lipoproteins and Cardiovascular Health
- Heart Failure Treatment and Management
- Drug-Induced Adverse Reactions
- Diabetes Treatment and Management
- Cardiovascular Issues in Pregnancy
- Tuberculosis Research and Epidemiology
- Urticaria and Related Conditions
- Infective Endocarditis Diagnosis and Management
- Pericarditis and Cardiac Tamponade
- Mechanical Circulatory Support Devices
- Acute Myocardial Infarction Research
Azienda Ospedaliera G. Brotzu
2012-2025
University of Cagliari
2001-2023
Azienda Ospedaliero-Universitaria Cagliari
2023
Azienda di Rilievo Nazionale ed Alta Specializzazione
2023
Casa di Cura San Michele
2022
University of Sassari
2017-2020
European Society of Hypertension
2020
Associazione Nazionale Medici Cardiologi Ospedalieri
2017
Policlinico S.Orsola-Malpighi
2017
University of Florence
2015
Abstract Background and Aims An electrical storm (ES) is a clinical emergency with paucity of established treatment options. Despite initial encouraging reports about the safety effectiveness percutaneous stellate ganglion block (PSGB), many questions remained unsettled evidence from prospective multicentre study was still lacking. For these purposes, STAR designed. Methods This observational enrolling patients suffering an ES refractory to standard 1 July 2017 30 June 2023. The primary...
The clinical course of patients with hypertrophic cardiomyopathy and advanced heart failure (HF) subtended by progressive left ventricular dysfunction has received limited attention. Our aim was to assess the outcome HF impact treatment options including implantable cardioverter-defibrillator transplantation (HT) in evaluated at 2 Italian referral centers >3 decades.All-cause mortality a combined end point death, HT, or appropriate shock were assessed 71 consecutive not related outflow...
Rationale: An initial oral combination of drugs is being recommended in pulmonary arterial hypertension (PAH), but the effects this approach on risk reduction and vascular resistance (PVR) are not known.Objectives: To test hypothesis that a low-risk status would be determined by PVR patients with PAH treated upfront drugs.Methods: The study enrolled 181 treatment-naive (81% idiopathic) follow-up right heart catheterization at 6 months (interquartile range, 144–363 d) after endothelin...
Abstract Aims Electrical storm (ES) is a life-threatening condition requiring rapid management. Percutaneous stellate ganglion block (PSGB) proved to be safe and effective on top of standard therapy, but no data are available about its early use. Methods results We considered all patients enrolled from 1 July 2017 30 April 2024 in the STAR registry (STellate for Arrhythmic stoRm), multicentre, international, observational, prospective registry. aimed assess effectiveness first PSGB only....
Recently, cardiac intensive care units (CICUs) have undergone a significant transformation related to the evolution in management of acute coronary syndrome and influenced by other factors such as epidemiological transition, increasing complexity clinical cases, technological advancement, growth scientific expertise cardiologists. In context this evolution, functional reorganization CICUs Italy has be implemented order meet changing needs population with cardiovascular disease requiring...
Demographic characteristics of pulmonary arterial hypertension (PAH) patients have changed over time, but the effects cardiovascular risk factors on status and vascular resistance (PVR) reduction with initial oral combination therapy are not known. Therefore, we tested relevance comorbidities in this setting.The study enrolled 181 treatment-naive PAH a 6-month (IQR 144-363 days) right heart catheterisation assessment after therapy.Group A included 96 (53.0%) without cardiac comorbidities;...
Although everolimus potentially improves long-term heart transplantation (HTx) outcomes, its early postoperative safety profile had raised concerns and needs optimization.This 6-month, open-label, multicenter randomized trial was designed to compare the cumulative incidence of a primary composite endpoint comprising wound healing delays, pericardial effusion, pleural effusion needing drainage, renal insufficiency events (estimated glomerular filtration rate ≤30/mL/min per 1.73 m) in de novo...
The coronavirus disease 2019 (COVID-19) outbreak has led to significant restrictions on routine medical care. We conducted a multicentre nationwide survey of patients with pulmonary arterial hypertension (PAH) determine the consequences governance measures PAH management and risk poor outcome in COVID-19.The present study, which included 25 Italian centres, considered demographic data, number in-person visits, 6-min walk echocardiographic test results, brain natriuretic peptide/N-terminal...
Patients suffering from acute coronary syndromes (ACS) present a high risk of recurrence and new adverse cardiovascular events after hospital discharge. Elevated plasma LDL-cholesterol (LDL-C) levels have been shown to be causal factor for the development heart disease, robust clinical evidence has documented that decrease LDL-C correlates linearly with reduction in events. Recent studies also demonstrated safety efficacy an early significant patients ACS.In this position paper, ANMCO...
Abstract Extended risk stratification and optimal management of patients with a permanently increased sudden cardiac death (SCD) are becoming increasingly important. There several clinical conditions where the arrhythmic is present albeit only transient. As an example, depressed left ventricular function have high SCD that may be transient if there will significant recovery function. It important to protect while receiving titrating dose recommended drugs lead improved In other conditions,...
Obesity is a chronic and relapsing disease characterized by the interaction between individual predispositions an obesogenic environment. Recent advances in understanding mechanisms of energetic homoeostasis paved way to more effective therapeutic approaches compared with traditional treatments. Since obesity complex disease, it necessitates multi-disciplinary approach whose implementation remains challenging. Nonetheless, emerging pharmacological interventions appear promising. Currently,...
Atherosclerosis often affects the coronary arterial tree. Frequently disease does not translate in significant narrowing of vessels, thus determining only a non-obstructive disease. This condition that is described as artery (NobsCAD) should be distinguished from absence (i.e. smooth arteries) it carries specific prognostic value. The detection and reporting NobsCAD prompt preventive measures can individualized upon degree underlying burden accompanying clinical condition, other...
Rheumatoid arthritis (RA) exhibit a cardiovascular (CV) risk that is 1.5-2.0 times higher compared to the general population. This CV excess likely caused by involvement of chronic inflammation and immune dysregulation. Therefore, conventional algorithms imaging techniques fail fully account for this provide suboptimal stratification, hence limiting clinical management in setting.Compelling evidence has suggested role adaptations (Framingham, SCORE, AHA, etc) or development RA-specific...
Background and aim Cardiac resynchronization therapy (CRT) reduces mortality morbidity in chronic heart failure symptomatic patients with broad QRS who are already undergoing optimal medical treatment. However, approximately one-third of implanted do not show any benefit from this Right ventricle (RV) dysfunction leads to a worse outcome failure, but its role predicting the response CRT has shown conflicting results. The purpose our study was investigate how RV function, assessed by cardiac...
Extended risk stratification and optimal management of patients with a permanently increased sudden cardiac death (SCD) is becoming increasingly important. There are several clinical conditions where the arrhythmic present albeit only transient. As an example, depressed left ventricular function have high SCD that may be transient when there significant recovery function. It important to protect while receiving recommended measures drugs either lead or not improved In other can observed even...
Patients suffering from acute coronary syndrome (ACS) present a high risk of recurrence and new adverse cardiovascular events after hospital discharge. Elevated plasma LDL-cholesterol (LDL-C) levels have been shown to be causal factor for the development heart disease, robust clinical evidence has documented that LDL-C decrease linearly correlates with reduction in events. Recent studies also demonstrated safety efficacy an early significant patients ACS. In this position paper, Italian...
Sodium-glucose cotransporter 2 (SGLT2) inhibitors, dapagliflozin, and empagliflozin, first developed as glucose-lowering agents for the treatment of Type diabetes, have been demonstrated to improve prognosis in patients with heart failure reduced ejection fraction (HFrEF) regardless presence diabetes. Since these drugs only recently included among four pillars HFrEF treatment, cardiologists are still unfamiliar their use this setting. This article provides an up-to-date practical guide...