A5087621587- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- Rheumatoid Arthritis Research and Therapies
- Cytokine Signaling Pathways and Interactions
- Monoclonal and Polyclonal Antibodies Research
- Spondyloarthritis Studies and Treatments
- Cell Adhesion Molecules Research
- Systemic Sclerosis and Related Diseases
- T-cell and B-cell Immunology
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immune cells in cancer
- COVID-19 Clinical Research Studies
- Inflammasome and immune disorders
- Diabetes and associated disorders
- Paraoxonase enzyme and polymorphisms
- Vitamin D Research Studies
- Psoriasis: Treatment and Pathogenesis
- Angiogenesis and VEGF in Cancer
- Inflammatory Biomarkers in Disease Prognosis
- Lymphoma Diagnosis and Treatment
- Gut microbiota and health
- Chemokine receptors and signaling
Universidad de Oviedo
2015-2024
Instituto de Investigación Sanitaria del Principado de Asturias
2018-2024
All India Institute of Medical Sciences Bhopal
2023
Columbia University
2023
Brigham and Women's Hospital
2023
Ulsan College
2023
Institute of Immunology
2023
University of Ulsan
2023
Asan Medical Center
2023
Central University Hospital of Asturias
2012-2021
Abstract Intestinal dysbiosis, characterized by a reduced Firmicutes / Bacteroidetes ratio, has been reported in systemic lupus erythematosus (SLE) patients. In this study, vitro cultures revealed that microbiota isolated from SLE patient stool samples (SLE-M) promoted lymphocyte activation and Th17 differentiation naïve CD4 + lymphocytes to greater extent than healthy control-microbiota. Enrichment of SLE-M with Treg-inducing bacteria showed mixture two Clostridia strains significantly the...
Metabolic impairments are a frequent hallmark of systemic lupus erythematosus (SLE). Increased serum levels Free Fatty Acids (FFA) commonly found in these patients, although the underlying causes remain elusive. Recently, it has been suggested that other factors than inflammation or clinical features may be involved. The gut microbiota is known to influence host metabolism, production Short Chain (SCFA) playing potential role. Taking into account patients exhibit an intestinal dysbiosis, we...
Some of the articles being published during severe acute respiratory syndrome–coronavirus (SARS-CoV)-2 pandemic highlight a link between forms coronavirus disease 2019 (COVID-19) and so-called cytokine storm, also with increased ferritin levels. However, this scenario is more complex than initially thought due to heterogeneity hyperinflammation. patients develop fully blown secondary haemophagocytic lymphohistiocytosis (sHLH), whereas others, despite consistent release pro-inflammatory...
Background Since the publication of 2011 European Alliance Associations for Rheumatology (EULAR) recommendations patient research partner (PRP) involvement in rheumatology research, role PRPs has evolved considerably. Therefore, an update was deemed necessary. Methods In accordance with EULAR Standardised Operational Procedures, a task force comprising 13 researchers, 2 health professionals and 10 convened. The process included online meeting, systematic literature review in-person second...
A growing body of evidence highlights the relevance free fatty acids (FFA) for human health, and their role in cross talk between metabolic status immune system. Altered serum FFA profiles are related to several conditions, although underlying mechanisms remain unclear. Recent studies have highlighted link gut microbiota host metabolism. However, most focused on different clinical these mediators healthy populations is lacking. Therefore, we addressed analysis relationship among microbial...
Abstract This study aims to analyze in depth the role of IFNα upregulation BLyS different leukocyte populations and possible relationship these molecules with IL-17 other pathogenic cytokines SLE. Thus, IFNAR1 membrane (mBLyS) expression was upregulated on various blood cell types from patients closely correlated all individuals. Moreover, serum levels associated positively IL-17A amounts, as well mBLyS B cells neutrophils. Interestingly, neutrophils also levels. Additionally, intracellular...
Type I interferons (IFN-Is) play a role in broad range of rheumatic and musculoskeletal diseases (RMDs), compelling evidence suggests that their measurement could have clinical value, although testing has not progressed into settings. To develop evidence-based points to consider (PtC) for the reporting IFN-I assays research determine potential utility. EULAR standardised operating procedures were followed. A task force including rheumatologists, immunologists, translational scientists...
Objective Innate lymphoid cells (ILCs) are emerging mediators of immunity, and accumulation inflammatory ILC populations can occur in inflammatory‐mediated conditions. Since early lymph node (LN) activation has been shown rheumatoid arthritis (RA), we aimed to investigate the frequency distribution ILCs LN biopsy specimens obtained during earliest phases RA. Methods Twelve patients with RA, 12 individuals IgM factor and/or anti–citrullinated protein antibodies without (RA risk group), 7...
Abstract The chronic inflammatory environment associated with systemic lupus erythematosus can lead to an accelerated immunosenescence responsible for the endothelial damage and increased cardiovascular risk observed in these patients. present study analyzed two populations opposite effects on vascular endothelium, angiogenic T cells senescent CD4+CD28null subset, 84 patients 46 healthy controls. Also, 48 rheumatoid arthritis 72 individuals traditional factors participated as disease...
Severe systemic inflammation associated with some stages of COVID-19 and in fatal cases led therapeutic agents developed or used frequently Rheumatology being at the vanguard experimental therapeutics strategies. The aim this project was to elaborate EULAR Points consider (PtCs) on pathophysiology immunomodulatory therapies.PtCs were accordance standard operating procedures for endorsed recommendations, by an international multidisciplinary Task Force, including rheumatologists,...
ABSTRACT Objective immune dysregulation may play a role in cardiovascular (CV) risk excess rheumatoid arthritis (RA). However, exact mediators are unknown. Age-associated B cells (ABCs) have emerged as multi-faceted pro-inflammatory mediators, also the atherosclerosis microenvironment, but their autoimmunity is ill-defined. Our aim was to evaluate ABCs levels earliest stages of inflammatory and potential biomarkers atherosclerosis. Methods were quantified by flow cytometry 58 early RA...
Objective: inflammation and repair responses may be involved in atherosclerosis rheumatoid arthritis (RA), although mechanisms are unknown. GPR55 is a cannabinoid receptor expressed hematopoietic stromal tissues, which has been implicated mouse models, but evidence humans lacking. Our aim was to evaluate expression leukocyte populations RA patients their potential role atherosclerosis. Methods: quantified by flow cytometry 63 untreated patients, 11 arthralgia individuals 36 controls....
Objective. The aim of this study was to investigate the endothelial progenitor cell population in SLE and early RA patients its potential relationships with disease features cytokine serum levels. Methods. Endothelial cells (EPCs), mature EPCs (mEPCs) (ECs) were measured peripheral blood samples from 83 85 39 healthy controls by flow cytometry on basis CD34, VEGF receptor 2 CD133 expression. Serum levels IL-1β, IL-6, IL-8, IL-17, VEGF-A, IFN-α, TGF-β GM-CSF quantified immunoassays. Clinical...
<h3>Objective</h3> The mechanisms underlying the increased cardiovascular risk (CVR) of rheumatoid arthritis (RA) patients remain unclear. Since recently discovered angiogenic T cells (Tang) could have a role in endothelial repair through cooperating with progenitor (EPC), main aim this study was to analyse Tang and EPC populations relation disease-specific features traditional CVR factors. <h3>Methods</h3> (CD3<sup>+</sup>CD31<sup>+</sup>CXCR4<sup>+</sup>)...