A5086055060- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Rheumatoid Arthritis Research and Therapies
- Atherosclerosis and Cardiovascular Diseases
- interferon and immune responses
- Autoimmune and Inflammatory Disorders Research
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Systemic Sclerosis and Related Diseases
- Inflammasome and immune disorders
- Lymphoma Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
- Salivary Gland Disorders and Functions
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Protein Tyrosine Phosphatases
- Diabetes and associated disorders
- CAR-T cell therapy research
- Immunodeficiency and Autoimmune Disorders
- Musculoskeletal Disorders and Rehabilitation
- Galectins and Cancer Biology
Hospital for Special Surgery
2015-2024
New York Hospital Queens
2006-2024
Cornell University
2015-2024
NewYork–Presbyterian Hospital
1986-2024
Weill Cornell Medicine
2022-2024
National and Kapodistrian University of Athens
2021
Springer Nature (Switzerland)
2021
Kirkland and District Hospital
2020
Pfizer (United Kingdom)
2013
Johnson & Johnson (Sweden)
2013
To develop new classification criteria for systemic lupus erythematosus (SLE) jointly supported by the European League Against Rheumatism (EULAR) and American College of Rheumatology (ACR).This international initiative had four phases. 1) Evaluation antinuclear antibody (ANA) as an entry criterion through systematic review meta-regression literature generation Delphi exercise, early patient cohort, a survey. 2) Criteria reduction nominal group technique exercises. 3) definition weighting...
Although systemic lupus erythematosus is associated with premature myocardial infarction, the prevalence of underlying atherosclerosis and its relation to traditional risk factors for cardiovascular disease lupus-related have not been examined in a case-control study.In 197 patients matched controls, we performed carotid ultrasonography, echocardiography, an assessment disease. The were also evaluated respect their clinical serologic features, inflammatory mediators, treatment.The similar...
Abstract Objective Gene‐expression studies have demonstrated increased expression of interferon (IFN)–inducible genes (IFIGs) in peripheral blood mononuclear cells (PBMCs) many patients with systemic lupus erythematosus (SLE), a predominant effect type I IFN. This study examined the hypothesis that disease severity and activity, as well distinct autoantibody specificities, characterize SLE activation IFN pathway. Methods Freshly isolated PBMCs from 77 patients, 22 controls, 28 healthy donors...
Abstract Objective To study the contribution of interferon‐α (IFNα) and IFNγ to IFN gene expression signature that has been observed in microarray screens peripheral blood mononuclear cells (PBMCs) from patients with systemic lupus erythematosus (SLE). Methods Quantitative real‐time polymerase chain reaction analysis healthy control PBMCs was used determine relative induction a panel IFN‐inducible genes (IFIGs) by IFNα IFNγ. 77 SLE were compared those 22 disease controls 28 donors for IFIGs....
The production of CXCL4 and IFN-α by plasmacytoid DCs in response to TLR8 signaling contributes skin fibrosis systemic sclerosis.
The specificity of T cell help for B activation and differentiation is maintained by the brief expression on surface, following receptor-mediated triggering, CD40 ligand (CD40L). Interaction helper (Th) CD40L with induces activation, surface antigens, proliferation, initiation immunoglobulin isotype switch. We predicted that in patients systemic lupus erythematosus (SLE), whom Th cell-dependent production autoantibodies results immune complex-mediated tissue damage, might be augmented,...
Abstract Objective Peripheral blood mononuclear cells (PBMCs) from patients with systemic lupus erythematosus (SLE) have increased expression of genes typically induced by type I interferon (IFN). However, it has been difficult to identify and quantify the factors responsible for activation IFN pathway in SLE. To characterize these mediators, we developed an assay that measures functional effects plasma or serum components on gene cultured target cells. Methods WISH epithelial cell line were...
Chronic inflammatory diseases are associated with premature atherosclerosis; however, it is unknown whether arterial stiffness increased in this setting, possibly as a manifestation of vascular disease preceding and/or independent atherosclerosis. Carotid ultrasonography and radial applanation tonometry were performed 101 patients systemic lupus erythematosus, 80 rheumatoid arthritis, 105 healthy control subjects. The 3 groups comparable age, gender, carotid artery absolute relative wall...
Background: Rheumatoid arthritis is associated with increased morbidity and mortality because of cardiovascular disease, independent traditional risk factors. Objective: To determine the prevalence preclinical atherosclerosis in patients rheumatoid to identify clinical biological markers for atherosclerotic disease this patient population. Design: Matched, cross-sectional study. Setting: Hospital Special Surgery New York City. Patients: 98 consecutive outpatients who were followed by...
The Apo-1/Fas antigen (CD95) mediates programmed cell death of lymphocytes when bound by Fas ligand or anti-Apo-1/Fas antibody. In contrast, the CD40 provides a potent activation and survival signal to B it is engaged its T (CD40L, gp39) cross-linked anti-CD40 this study, we use human tonsillar cells Ramos Burkitt's lymphoma line, which serves as model for germinal center lymphocytes, study effectors expression apoptosis cells. We found that was upregulated on both malignant normal after...
Abstract Objective A haplotype of the interferon regulatory factor 5 (IRF5) gene has been associated with risk developing systemic lupus erythematosus (SLE), and our previous studies have demonstrated that high levels serum interferon‐α (IFNα) activity are a heritable for SLE. The aim this study was to determine whether IRF5 SLE mediates by predisposing patients development IFNα activity. Methods in 199 European Hispanic ancestry were measured sensitive functional reporter cell assay....
<h3>Objective:</h3> To investigate the effect of tumour necrosis factor (TNF) blocking agent infliximab in patients with treatment-resistant inflammatory myopathies. <h3>Methods:</h3> A total 13 refractory polymyositis (PM), dermatomyositis (DM), or inclusion body myositis (IBM) were treated 4 infusions (5 mg/kg weight) over 14 weeks. Outcome measures included disease activity score improvement defined according to The International Myositis Assessment and Clinical Studies Group (IMACS),...