A5037034997- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- Allergic Rhinitis and Sensitization
- Monoclonal and Polyclonal Antibodies Research
- Respiratory viral infections research
- Pediatric health and respiratory diseases
- Chemokine receptors and signaling
- Advanced Glycation End Products research
- Inflammasome and immune disorders
- Studies on Chitinases and Chitosanases
- Respiratory and Cough-Related Research
- NF-κB Signaling Pathways
- Cytokine Signaling Pathways and Interactions
- Mast cells and histamine
- Food Allergy and Anaphylaxis Research
- Cell Adhesion Molecules Research
- Antimicrobial Peptides and Activities
- interferon and immune responses
- Cancer Immunotherapy and Biomarkers
- Eosinophilic Esophagitis
- Inhalation and Respiratory Drug Delivery
Pfizer (United States)
2011-2021
Centers for New Horizons
2011-2021
Pfizer (United Kingdom)
2018-2020
University of Glasgow
2019
McMaster University Medical Centre
2012-2014
Autoimmune Technologies (United States)
2014
McMaster University
2001-2011
Hacettepe University
2011
Millennium Engineering and Integration (United States)
2000-2009
Ball (France)
2009
Although the role of Toll-like receptors in extracellular bacterial sensing has been investigated intensively, intracellular detection bacteria through Nod molecules remains largely uncharacterized. Here, we show that human Nod1 specifically detects a unique diaminopimelate-containing N -acetylglucosamine– -acetylmuramic acid (GlcNAc-MurNAc) tripeptide motif found Gram-negative peptidoglycan, resulting activation transcription factor NF-κB pathway. Moreover, epithelial cells (which represent...
T helper (Th) cells can be categorized according to their cytokine expression. The differential induction of Th expressing Th1 and/or Th2 cytokines is key the regulation both protective and pathological immune responses. Cytokines are expressed transiently there a lack stably surface molecules, significant for functionally different types cells. Such molecules utmost importance analysis selective functional modulation subsets will provide new therapeutic strategies treatment allergic or...
The complex pathophysiology of lung allergic inflammation and bronchial hyperresponsiveness (BHR) that characterize asthma is achieved by the regulated accumulation activation different leukocyte subsets in lung. development maintenance these processes correlate with coordinated production chemokines. Here, we have assessed role chemokines play BHR blocking their activities vivo. Our results show blockage each one reduces both infiltration a substantially way. Thus, eotaxin neutralization...
The evolutionarily conserved 18-glycosyl-hydrolase family contains true chitinases and chitinase-like proteins that lack enzymatic activity. Acidic mammalian chitinase has recently been associated with animal models of asthma. related protein, YKL-40 (also called human cartilage glycoprotein 39 [HCgp-39] 3-like 1), can be readily measured in the serum. However, its relationship to asthma not evaluated.We quantified serum levels three cohorts patients asthma--one recruited from patient...
The aim of this study was to investigate whether dendritic cells (DCs) can induce sensitization aeroallergen in a mouse model allergic asthma. Ovalbumin-pulsed (OVA-pulsed) or unpulsed myeloid DCs that were injected into the airways naive mice migrated mediastinal lymph nodes. When challenged 2 weeks later with an aerosol OVA, activated CD4 and CD8 lymphocytes, eosinophils, neutrophils recruited lungs actively immunized mice. These CD4+ lymphocytes produced predominantly IL-4 IL-5 but also...
It is now fully appreciated that asthma a disease of chronic nature resulting from intermittent or continued aeroallergen exposure leading to airway inflammation. To investigate responses continuous antigen exposure, mice were exposed either house dust mite extract (HDM) ovalbumin intranasally for five consecutive days, followed by 2 days rest, up seven weeks. Continuous HDM, unlike ovalbumin, elicited severe and persistent eosinophilic Flow cytometric analysis demonstrated an accumulation...
Fetal survival during gestation implies that tolerance mechanisms suppress the maternal immune response to paternally inherited alloantigens. Here we show inhibitory T cell costimulatory molecule, programmed death ligand 1 (PDL1), has an important role in conferring fetomaternal allogeneic pregnancy model. Blockade of PDL1 signaling murine resulted increased rejection rates concepti but not syngeneic concepti. was cell- B cell-dependent because PDL1-specific antibody treatment caused fetal...
Mouse breast regression protein 39 (BRP-39; Chi3l1) and its human homologue YKL-40 are chitinase-like proteins that lack chitinase activity. Although is expressed in exaggerated quantities correlates with disease activity asthma many other disorders, the biological properties of BRP-39/YKL-40 have only been rudimentarily defined. We describe generation characterization BRP-39−/− mice, transgenic mice BRP-39 produce their pulmonary epithelium. Studies these demonstrated animals markedly...
Psoriasis is a chronic inflammatory disorder of the skin affecting approximately 2% world’s population. Accumulating evidence has revealed that IL-23/IL-17/IL-22 pathway key for development immunopathology. However, role keratinocytes and their crosstalk with immune cells at onset disease remains poorly understood. Here, we show IL-36R–deficient (Il36r–/–) mice were protected from imiquimod-induced expansion dermal IL-17–producing γδ T psoriasiform dermatitis. Furthermore, IL-36R...
We report that like other T cells cultured in the presence of transforming growth factor (TGF) β, Th17 also produce interleukin (IL) 9. generated vitro with IL-6 and TGF-β as well purified ex vivo both produced IL-9. To determine if IL-9 has functional consequences Th17-mediated inflammatory disease, we evaluated role development progression experimental autoimmune encephalomyelitis, a mouse model multiple sclerosis. The data show neutralization receptor deficiency attenuates this correlates...
Caspase-1 is activated by a variety of stimuli after the assembly “inflammasome,” an activating platform made up complex NOD-LRR family proteins. required for secretion proinflammatory cytokines, such as interleukin (IL)-1β and IL-18, involved in control many bacterial infections. Paradoxically, however, its absence has been reported to confer resistance oral infection Salmonella typhimurium. We show here that caspase-1 or components inflammasome does not result S. typhimurium, but rather,...