A5065480404- Asthma and respiratory diseases
- Social and Educational Sciences
- Mast cells and histamine
- Pediatric health and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- IL-33, ST2, and ILC Pathways
- Diabetes and associated disorders
- Allergic Rhinitis and Sensitization
- Pancreatic function and diabetes
- Food Allergy and Anaphylaxis Research
- Diabetes Management and Research
- Early Childhood Education and Development
- Respiratory and Cough-Related Research
- Social Media and Politics
- Impact of Technology on Adolescents
- Neonatal Respiratory Health Research
- Child Development and Digital Technology
- Immune Response and Inflammation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immunotherapy and Immune Responses
- Proteoglycans and glycosaminoglycans research
- Eosinophilic Esophagitis
- Respiratory viral infections research
- Viral Infections and Vectors
- Research in Social Sciences
Lund University
2014-2024
Halmstad University
2024
Centre for Research in Engineering Surface Technology
2024
Research Institute of Industrial Economics
2024
Swedish University of Agricultural Sciences
2024
Institute of Religious Studies
2024
Howard Hughes Medical Institute
2021-2022
University of Massachusetts Chan Medical School
2021-2022
Lund Science (Sweden)
2013-2020
Imperial College London
2015-2020
Abstract Interstitial lung diseases such as idiopathic pulmonary fibrosis (IPF) are caused by persistent micro-injuries to alveolar epithelial tissues accompanied aberrant repair processes. IPF is currently treated with pirfenidone and nintedanib, compounds which slow the rate of disease progression but fail target underlying pathophysiological mechanisms. The DNA protein 8-oxoguanine glycosylase-1 (OGG1) has significant roles in modulation inflammation metabolic syndromes. Currently, no...
IL-9 is a pleiotropic cytokine that has multiple effects on structural as well numerous hematopoietic cells, which are central to the pathogenesis of asthma.
Lung mast cells are stereotypically divided into connective tissue (MC(TC)) and mucosal (MC(T)) cells. This study tests the hypothesis that each of these subtypes can be further site-specific populations created by microenvironment within anatomical lung compartment.Surgical resections bronchial transbronchial biopsies from non-smoking individuals were obtained to under non-inflamed conditions. Morphometric molecular characteristics cell investigated in multiple structures...
Neutrophils and IL-17A have been linked mechanistically in models of allergic airways disease associated with asthma severity. However, their role pediatric is unknown.We sought to investigate the neutrophils pathway mediating severe therapy-resistant (STRA).Children STRA (n = 51; age, 12.6 years; range, 6-16.3 years) controls without 15; 4.75 1.6-16 underwent clinically indicated fiberoptic bronchoscopy, bronchoalveolar lavage (BAL), endobronchial brushings, biopsy. Neutrophils, IL-17A,...
Abstract Argonaute proteins use nucleic acid guides to find and bind specific DNA or RNA target sequences. have diverse biological functions many retain their ancestral endoribonuclease activity, cleaving the phosphodiester bond between nucleotides t10 t11. In animals, PIWI proteins—a specialized class of proteins—use 21–35 nucleotide PIWI-interacting RNAs (piRNAs) direct transposon silencing, protect germline genome, regulate gene expression during gametogenesis 1 . The piRNA pathway is...
Mast cells have important roles in innate immunity and tissue remodeling but remained poorly studied inflammatory airway diseases like chronic obstructive pulmonary disease (COPD).To perform a detailed histological characterization of human lung mast cell populations at different severities COPD, comparing with smoking never-smoking control subjects.Mast were analyzed tissues from patients mild to very severe GOLD I-IV (n = 25, 10 whom treated corticosteroids). Never-smokers smokers served...
ABSTRACT Crimean-Congo hemorrhagic fever virus (CCHFV) causes viral with high case-fatality rates and is geographically widely distributed. Due to the requirement for a biosafety level 4 (BSL-4) laboratory lack of an animal model, knowledge pathogenesis limited. (CCHF) characterized by hemorrhage vascular permeability, indicating involvement endothelial cells (ECs). The interplay between ECs CCHFV therefore important understanding CCHF. In previous study, we found that CCHFV-infected...
Aims: We tested whether autoantibodies to all three ZnT8RWQ variants, GAD65, insulinoma-associated protein 2 (IA-2), insulin and islet cell cytoplasm (ICA) in combination with human leukocyte antigen (HLA) would improve the diagnostic sensitivity of childhood type 1 diabetes by detecting children who otherwise have been autoantibody-negative.Methods: A total 686 patients diagnosed 1996–2005 Skåne were analyzed for seven [arginin 325 zinc transporter 8 autoantibody (ZnT8RA), tryptophan...
Abstract Background Although mast cells are regarded as important regulators of inflammation and tissue remodelling, their role in cystic fibrosis (CF) idiopathic pulmonary (IPF) has remained less studied. This study investigates the densities phenotypes cell populations multiple lung compartments from patients with CF, IPF never smoking controls. Methods Small airways, vessels, parenchyma were subjected to detailed immunohistochemical analyses using lungs CF (20 regions; 5 patients), (21 7...
Arachidonate 15-lipoxygenase (LO)-1 has been implicated in allergic inflammation and asthma. The overall effect of 15-LO vivo is, however, unclear. This study investigates systemic allergen sensitization local airway remodeling mice lacking the murine 12/15-LO, ortholog to human 15-LO-1. Upon with intraperitoneal ovalbumin, 12/15-LO-/- produced elevated levels allergen-specific immunoglobulin E compared wild-type (Wt) controls. However, when challenged repeated aerosolized allergen,...
Objective To establish the diagnostic sensitivity of and relationships between autoantibodies to all three Zinc transporter 8 (Zinc autoantibody either one, two, or amino acid variants at position 325, ZnT8A) human leukocyte antigen (HLA)-DQ glutamic decarboxylase (GADA), insulinoma-associated protein 2 (IA-2A), insulin (IAA). Methods We analyzed 3165 patients with type 1 diabetes (T1D) in Better Diabetes Diagnosis study for HLA-DQ genotypes six (ZnT8RA, arginine 325 autoantibody; ZnT8WA,...
Purpose The purpose of this paper is to understand how meaning assigned online searching by viewing it as a mundane, yet often invisible, activity everyday life and an integrated part various social practices. Design/methodology/approach Searching investigated with sociomaterial approach starting point in information entangled across practices material arrangements mundane life. In total, 21 focus groups 127 participants have been carried out. study focusses particularly on peoples’...
Summary Background The toll‐like receptors, TLR5 and TLR7, have recently been proposed in asthma immunopathogenesis. While supporting data come from animal or vitro studies, little is known about TLR7 expression human asthmatic airways. Methods Advanced immunohistochemical mapping of was performed on bronchial transbronchial biopsies healthy individuals patients with moderate severe asthma. Results identified multiple structural cells; epithelium, alveolar type II pneumocytes, plasma cells,...
Airway hyperresponsiveness (AHR) to inhaled mannitol is associated with indirect markers of mast cell activation and eosinophilic airway inflammation. It unknown how AHR relates phenotype, function measures inflammation in tissue. We compared the number phenotype cells, mRNA expression cell-associated genes eosinophils tissue subjects asthma healthy controls relation mannitol.Airway was measured 23 non-smoking, corticosteroid-free asthmatic individuals 10 controls. Mast cells were identified...
Abstract Background De novo lymphatic vessel formation has recently been observed in lungs of patients with moderate chronic obstructive pulmonary disease (COPD). However, the distribution changes among anatomical compartments diseased is unknown. Furthermore, information regarding nature alterations across different stages COPD missing. This study performs a detailed morphometric characterization vessels major peripheral lung severities and investigates expression molecules involved immune...
The study was designed to determine whether dopaminergic neurotransmission in the retina can operate via volume transmission. In double immunolabelling experiments, a mismatch as well match demonstrated rat between tyrosine hydroxylase (TH) and dopamine (DA) immunoreactive (ir) terminals cell bodies D2 receptor-like ir processes. regions were located inner nuclear plexiform layers (D2 plus processes). ganglion layer, outer segment of photoreceptor where very few TH be found relation like...
Aims The aim of this study was to explore whether islet cell antibodies (ICA) could be identified in children with newly onset diabetes mellitus but negative for autoantibodies against glutamic acid decarboxylase (GADA), antigen-2 (IA-2A), insulin (IAA), or any the three variants arginine (R), tryptophan (W), glutamine (Q) at position 325 zinc transporter 8 (ZnT8A). Methods A population-based analysis performed from 1 May 2005 2 September 2010 Swedish diagnosed diabetes. ICA analyzed an...
<h3>Rationale</h3> The alveolar pathology in chronic obstructive pulmonary disease (COPD) involves antigen-driven immune events. However, the induction sites of adaptive responses have remained poorly investigated. <h3>Objectives</h3> To explore hypothesis that interfaces between lumen and lymphoid aggregates (LAs) provide a structural basis for increased antigen uptake COPD lungs. <h3>Methods</h3> Lung samples from patients with mild (Global Initiative Chronic Obstructive Disease (GOLD)...