A5101885753- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Management and Research
- Microscopic Colitis
- Gastroesophageal reflux and treatments
- Liver Disease Diagnosis and Treatment
- Immune Response and Inflammation
- Peroxisome Proliferator-Activated Receptors
- Respiratory viral infections research
- Inflammatory Bowel Disease
- Thyroid Cancer Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Renal Transplantation Outcomes and Treatments
- Contact Dermatitis and Allergies
- Pregnancy and Medication Impact
- Adipokines, Inflammation, and Metabolic Diseases
- Fatty Acid Research and Health
- Autoimmune and Inflammatory Disorders
- Viral gastroenteritis research and epidemiology
- Sleep and related disorders
- Potassium and Related Disorders
- Glutathione Transferases and Polymorphisms
- Biochemical Analysis and Sensing Techniques
- Porphyrin Metabolism and Disorders
- Metabolomics and Mass Spectrometry Studies
Lund University
1996-2024
Östersunds Hospital
2013-2021
Skåne University Hospital
2017-2021
The aim of the study was 1) to establish prevalence GAD antibodies (GADab) in a population-based type 2 diabetes western Finland, 2) genetically and phenotypically characterize this subgroup, 3) provide definition for latent autoimmune adults (LADA). GADab 9.3% among 1,122 diabetic patients, 3.6% 558 impaired glucose tolerance (IGT) subjects, 4.4% 383 nondiabetic control subjects. Islet antigen (IA2ab) or islet cell were detected only 0.5% GADab- patients. GADab+ patients had lower fasting...
Aims: We tested whether autoantibodies to all three ZnT8RWQ variants, GAD65, insulinoma-associated protein 2 (IA-2), insulin and islet cell cytoplasm (ICA) in combination with human leukocyte antigen (HLA) would improve the diagnostic sensitivity of childhood type 1 diabetes by detecting children who otherwise have been autoantibody-negative.Methods: A total 686 patients diagnosed 1996–2005 Skåne were analyzed for seven [arginin 325 zinc transporter 8 autoantibody (ZnT8RA), tryptophan...
Summary Aims : To investigate the gastrointestinal pharmacokinetics of controlled‐release (Entocort) and standard budesonide capsules. Methods Six Crohn's disease patients eight healthy controls were given capsules containing an inert 111 In label, following breakfast. patients, a capsule deuterium‐labelled was simultaneously. controls, on separate occasion, in fasting state. Gastrointestinal transit recorded by gamma camera. Plasma used to estimate drug release, urine cortisol assess...
PATIENTS: Seven patients with Barrett9s metaplastic epithelium and oesophageal adenocarcinoma were investigated by means of laser induced fluorescence after low dose intravenous injection (0.35 mg/kg bw) Photofrin (QLT, Vancouver, Canada). Laser measurements performed immediately resection the oesophagus. METHODS: spectra recorded from 15-30 locations in each surgical specimen normal mucosa, epithelium, tumour tissue. Histological examination was on location to correlate spectral...
AbstractIt is controversial whether bile salts are important in the pathogenesis of esophagitis. By sampling esophageal contents during ambulatory 24-h pH-monitoring we found that a group 18 patients with esophagitis all but 1 had detectable concentrations their esophagus. The were low, however, and similar to those gastric juice 10 normal controls. It concluded present esophagus presence results from duodenogastric reflux. role these refluxed is, unclear.Key Words: Bile saltsduodenogastric...
Environmental factors, including viral infections, may explain an increasing and fluctuating incidence of childhood type 1 diabetes (T1D). Ljungan virus (LV) isolated from bank voles have been implicated, but it is unclear whether LV contributes to islet autoimmunity, progression clinical onset, or both, T1D. The aim was test antibodies (LVAb) were related HLA-DQ autoantibodies in newly diagnosed T1D patients (n=676) controls (n=309). Patients, 0–18 years age, with 1996–2005 analyzed for...
AbstractHertervig E, Nilsson Å, Seidegård JE. The expression of glutathione transferase μ in patients with inflammatory bowel disease. Scand J Gastroenterol 1994;29:729-735.Background: Glutathione transferases (GST) are a group multifunctional enzymes important the detoxification many electrophiles and, addition, fatty acid hydroperoxides, thus limiting tissue damage from oxidative free radical attack. Of four classes GST (alpha, mu, pi, and theta), class mu isoenzyme, u., is dominantly...
Abstract The chylomicron phosphatidylcholines from rats fed safflower oil or triolein were isolated and separated into four different fractions according to the degree of unsaturation. Fraction 1, which was rich in palmitic, stearic oleic acid, a minor fraction (7.6–11.6 mole%) during absorption oil, but quantitatively important (27–51 after feeding when significant amounts dioleoylphosphatidylcholine present. 2, major all experiments, contained linoleic acid combination with saturated...
The aim of the study was to investigate effect non-allergenic structural analogues on sensitizing potential carvone, a fragrance allergen. possibility that one molecule might inhibit allergenic activity another has been debated for 25 years. Research Institute Fragrance Materials states from certain aldehydes is "quenched" by addition other specific chemicals. However, studies do not confirm results, although several attempts have made. We used guinea pig method designed capacity allergens....
The magnesium status was evaluated in 30 subjects with Crohn's disease and controls. Subjects had lower concentrations of muscle biopsy specimens (p less than 0.001), mononuclear cells 0.05), urine collected during 24 h 0.001) as compared After intravenous infusion 60 mmol 80 potassium to 17 a significant increase 0.01), plasma 0.01) noted. retention intravenously infused significantly higher 11 healthy controls inversely correlated the content (r = -0.52; p 0.05). implication these findings...
We have previously shown that bile duct ligation inhibits the hepatic uptake of chylomicron remnants in rats. In present study we investigated different possible causes this inhibition. Intravenous infusion or sodium taurocholate reduced remnant uptake. Perfused livers from duct-ligated rats metabolized at a rate. Rat hepatocyte monolayer cultures formed cholestatic and those hepatectomized animals equally well, but serum inhibited more strongly than control serum. Bile did not influence...
Autoimmune thyroid disease (AITD) may be detected prior to clinical symptoms through the presence of autoantibodies against peroxidase (TPOab), thyroglobulin (TGab), or both.The present study aimed develop a novel radiobinding assay (RBA) for TPOab and determine prevalence TGab in Swedish population.Patient samples from 27 newly diagnosed Graves' patients longitudinal follow-up 124 AITD autoantibody-positive children prospective increased risk type 1 diabetes were included validate RBA TPO....
Ljungan virus (LV), a Parechovirus of the Picornavirus family, first isolated from bank vole at river in Sweden, has been implicated risk for autoimmune type 1 diabetes. An assay neutralizing antibodies (NLVA) was developed using original 87–012 LV isolate. The goal to determine NLVA titres incident 0–18 years old newly diagnosed diabetes patients ( n =67) and school children controls =292) Jämtland county Sweden. were found 41 67 (61 %) compared 127 292 (44 P =0.009). In patients,...
AbstractHyperlipidaemia frequently accompanies infectious diseases and may be due to an increase in lipoprotein production or a decrease of clearance. The administration endotoxin has been used mimic infection previous studies have demonstrated that induces low density (LDL) levels. In the present study rats, dose (055:B5, 50 μg 100 g body weight−1) induced hyperlipidaemia without shock death. dearance 125I-LDL was measured after simultaneous injection LDL protein with (control). Endotoxin...
AbstractHyperlipidaemia frequently accompanies infectious diseases and may be due to an increase in lipoprotein production or a decrease of clearance. The administration endotoxin has been used mimic infection previous studies have demonstrated that induces low density (LDL) levels. In the present study rats, dose (055:B5, 50 μg 100 g body weight−1) induced hyperlipidaemia without shock death. dearance 125I-LDL was measured after simultaneous injection LDL protein with (control). Endotoxin...
Pure human pancreatic phospholipase A2 efficiently hydrolyzed the 2-ester bond of 14C-2-linoleoyl and 14C-2-arachidonyl phosphatidylinositol (PI). The rate hydrolysis varied markedly with bile salt (sodium taurocholate to sodium taurodeoxy-cholate, 3:4 mol/mol) concentration, being decreased increasing PI ratio. influence salts was thus similar that which has earlier been described for phosphatidylcholine (PC) pig A2. When 2-3H-arachidonyl PC 2-14C-arachidonyl were incorporated into a mixed...