A5087060967- Sepsis Diagnosis and Treatment
- Machine Learning in Healthcare
- Neonatal and Maternal Infections
- Explainable Artificial Intelligence (XAI)
- Artificial Intelligence in Healthcare
- Mental Health Treatment and Access
- Tuberculosis Research and Epidemiology
- Immune Response and Inflammation
- Pancreatic function and diabetes
- Complement system in diseases
- Diabetes Management and Research
- Lipid metabolism and disorders
- Diabetes Treatment and Management
- Sirtuins and Resveratrol in Medicine
- Emergency and Acute Care Studies
- SARS-CoV-2 and COVID-19 Research
- Artificial Intelligence in Healthcare and Education
- Long-Term Effects of COVID-19
- Migration, Health and Trauma
- Virus-based gene therapy research
- Metabolism, Diabetes, and Cancer
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- Diabetes and associated disorders
- Bacterial Infections and Vaccines
St Olav's University Hospital
2017-2024
Norwegian University of Science and Technology
2017-2024
Medizinische Hochschule Hannover
2012-2015
Lund University
1999
The aim of the study was 1) to establish prevalence GAD antibodies (GADab) in a population-based type 2 diabetes western Finland, 2) genetically and phenotypically characterize this subgroup, 3) provide definition for latent autoimmune adults (LADA). GADab 9.3% among 1,122 diabetic patients, 3.6% 558 impaired glucose tolerance (IGT) subjects, 4.4% 383 nondiabetic control subjects. Islet antigen (IA2ab) or islet cell were detected only 0.5% GADab- patients. GADab+ patients had lower fasting...
TLR8 is an endosomal sensor of RNA degradation products in human phagocytes, and involved the recognition viral bacterial pathogens. We previously showed that primary monocytes monocyte derived macrophages, senses entire Staphylococcus aureus Streptococcus agalactiae (group B streptococcus, GBS), resulting activation IRF5 production IFNβ, IL-12p70, TNF. However, quantitative qualitative impact for sensing bacteria have remained unclear because selective inhibitors been unavailable. Moreover,...
This study aimed to investigate the predictive capabilities of historical patient records predict adverse outcomes such as mortality, readmission, and prolonged length stay (PLOS).
TLR8 is the major endosomal sensor of degraded RNA in human monocytes and macrophages. It has been implicated sensing viruses more recently also bacteria. We previously identified a TLR8-IFN regulatory factor 5 (IRF5) signaling pathway that mediates IFNβ interleukin-12 (IL-12) induction by Staphylococcus aureus antagonized TLR2. The relative importance for various bacterial species however still unclear. here compared role IRF5 Group B Streptococcus (GBS), S. aureus, Escherichia coli primary...
Human cord blood (CB)-derived hematopoietic stem cells (HSCs) are an interesting source for HSC transplantation. However, the number of collected CB-HSCs is often too low one transplantation; therefore, ex vivo expansion desirable. Current protocols based on use cytokine combinations, including insulin-like growth factor-binding protein 2 (IGFBP2) and angiopoietin-like proteins, or combinations with "small molecules" such as stemregenin-1. The aim our project was to compare potential...
26.02.2024: Originalartikkel - Den største forskjellen i kodepraksis mellom helseforetakene var Helse Vest og Midt-Norge, med en absolutt forskjell på 12,9 % andel sepsiskoder kjent fokus perioden 1.
To assess the efficacy and long-term effects of glipizide treatment on glucose insulin metabolism in individuals with impaired tolerance (IGT).Thirty-seven first-degree relatives patients type 2 diabetes fulfilling WHO criteria for IGT were randomized to either 2.5 mg once daily or matching placebo 6 months. A 75 g, 2-h oral (OGTT) 60 min intravenous test (IVGTT) performed at baseline after The subjects followed up another 12 months discontinuation a repeat OGTT was 18 months.Thirty-three...
Abstract We recently showed that TLR8 is critical for the detection of Gram-positive bacteria by human monocytes. Here, we hypothesized and complement together regulate antibacterial responses in blood. Anticoagulated blood was treated with selective inhibitors and/or C5, then challenged live Streptococcus agalactiae (Group B streptococcus, GBS), Staphylococcus aureus, or Escherichia coli. Cytokine production, plasma membrane permeability, bacterial survival, phagocytosis, activation...
Infection in the immunocompromised patient is often challenging on multiple levels. It can be difficult to distinguish between manifestations of underlying disease, infection or malignancy. Symptoms may vague even absent, deviations common inflammatory parameters discrete, imaging findings scarce and causative microbe a true pathogen as well opportunistic. Here, we report an immunosuppressed female her late teens with purulent meningitis due Ureaplasma parvum— very rare cause central nervous...
Abstract Bloodstream infections (BSIs) represent a critical public health concern, primarily due to their rapid progression and severe implications such as sepsis septic shock. This study introduces an innovative Explanable Artificial Intelligence (XAI) framework, leveraging historical electronic records (EHRs) enhance BSI prediction. Unlike traditional models that rely heavily on real-time clinical data, our XAI-based approach utilizes comprehensive dataset incorporating demographic...
Abstract Background This study aims to explore the varied experiences of patients with drug-resistant tuberculosis in Norway. The emphasizes challenges and implications being diagnosed tuberculosis, including impact on psychosocial health during diagnosis, disease, treatment, isolation recovery phases. Norway is a low endemic country tuberculosis. Most are immigrants, some them have recently arrived country. Patients undergoing treatment for endure prolonged demanding that could affect their...
Bloodstream infections (BSIs) are a severe public health threat due to their rapid progression into critical conditions like sepsis. This study presents novel eXplainable Artificial Intelligence (XAI) framework predict BSIs using historical electronic records (EHRs). Leveraging dataset from St. Olavs Hospital in Trondheim, Norway, encompassing 35,591 patients, the integrates demographic, laboratory, and comprehensive medical history data classify patients high-risk low-risk BSI groups. By...
Methods to expand hematopoietic stem cells (HSCs) ex vivo encompass an attractive approach that would substantially broaden the clinical applicability of HSCs derived from cord blood (CB). Recently, members angiopoietin-like (Angptl) family growth factors were shown both murine and human HSCs. Specifically, Angptl5 has been implicated in expansion NOD/SCID-repopulating (SRCs) vivo. Here, we sought evaluate potential additional Angptls SRCs CB. Additionally, purpose this study was...
Abstract Background: This study aims to explore the varied experiences of patients with resistant tuberculosis in Norway, particularly among immigrants. The emphasizes challenges and implications being diagnosed tuberculosis, including impact psychosocial health during disease, treatment, isolation recovery phases. Norway is a low endemic country tuberculosis. Most are immigrants some have recently arrived country. Patients undergoing treatment for drug-resistant endure prolonged demanding...
Abstract Objective The aim of this study was to investigate predictive capabilities historical records patients maintained at hospitals towards predicting an impending adverse outcomes such as, mortality, readmission, and prolonged length stay (PLOS). Methods Leveraging a de-identified dataset from tertiary care university hospital, we developed eXplainable Artificial Intelligence (XAI) framework combining tree-based traditional ML models with interpretations, statistical analysis predictors...
<title>Abstract</title> Patients with drug resistant tuberculosis in Norway are often from immigrant backgrounds. In addition to undergoing long-term and demanding treatment, many face challenges related their recent arrival the country. This study aims explore healthcare workers' perspective of psychosocial needs these patients, focusing on such as cultural barriers, communication, impact social economic conditions patient adherence well-being. By addressing challenges, seeks contribute...