A5025719958- Transplantation: Methods and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Organ Transplantation Techniques and Outcomes
- Asthma and respiratory diseases
- Pulmonary Hypertension Research and Treatments
- Mechanical Circulatory Support Devices
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tracheal and airway disorders
- Cystic Fibrosis Research Advances
- Proteoglycans and glycosaminoglycans research
- Molecular spectroscopy and chirality
- Respiratory Support and Mechanisms
- Inhalation and Respiratory Drug Delivery
- Temporomandibular Joint Disorders
- Neonatal Respiratory Health Research
- Respiratory and Cough-Related Research
- Computational Drug Discovery Methods
- Mesenchymal stem cell research
- Renal Transplantation Outcomes and Treatments
- Oropharyngeal Anatomy and Pathologies
- Medical Imaging and Pathology Studies
- Occupational exposure and asthma
- Inorganic and Organometallic Chemistry
- Tissue Engineering and Regenerative Medicine
- Peptidase Inhibition and Analysis
John Wiley & Sons (United Kingdom)
2015-2023
John Brown University
2015-2023
Lund University
2007-2021
Skåne University Hospital
2011-2021
AstraZeneca (Sweden)
2010-2019
AstraZeneca (United Kingdom)
2012
Aristotle University of Thessaloniki
2011
Monash University
2005-2008
Umeå University
2006
The Alfred Hospital
2005
Abstract The aim of the present clinical trial was to test tolerability during 2 treatments with EMDOGAIN® in a large number patients. An open, controlled study design 10 Swedish specialist clinics chosen, group 107 patients treated connection periodontal surgery at surgical sites per patient. procedures were performed 6 weeks apart on one‐rooted teeth least 4 mm deep intraosseous lesions. A control 33 underwent flap without I comparable site. In total 214 and surgeries performed. Serum...
Airway remodeling in COPD includes reorganization of the extracellular matrix. Proteoglycans play a crucial role this process as regulators integrity Altered proteoglycan immunostaining has been demonstrated lungs and suggested to contribute pathogenesis. The major cell type responsible for production maintenance ECM constituents, such proteoglycans, are fibroblasts. Interestingly, it proposed that central airways alveolar lung parenchyma contain distinct fibroblast populations. This study...
Abstract Background Although mast cells are regarded as important regulators of inflammation and tissue remodelling, their role in cystic fibrosis (CF) idiopathic pulmonary (IPF) has remained less studied. This study investigates the densities phenotypes cell populations multiple lung compartments from patients with CF, IPF never smoking controls. Methods Small airways, vessels, parenchyma were subjected to detailed immunohistochemical analyses using lungs CF (20 regions; 5 patients), (21 7...
Idiopathic pulmonary fibrosis (IPF) is characterized by aberrant deposition of extracellular matrix (ECM) constituents, including glycosaminoglycans (GAGs), that may play a role in remodelling processes influencing critical mediators such as growth factors. We hypothesize GAGs be altered IPF and this contribute to create pro-fibrotic environment. The aim study was therefore examine the fine structure heparan sulfate (HS), chondroitin/dermatan (CS/DS) hyaluronan (HA) lung samples from...
Abstract Remodelling of the extracellular matrix is accomplished by altering balance between macromolecule production and degradation. However, it not well understood how cells new molecules degradation existing ones during tissue remodelling regeneration. In this study, we used decellularized lung scaffolds repopulated with allogenic fibroblasts cultured stable isotope labelled amino acids to quantify at a proteome-wide scale. Specific temporal dynamics different matrisome proteins were...
Abstract Mesenchymal stromal cells (MSC) are multipotent with regenerative and immune-modulatory properties. Therefore, MSC have been proposed as a potential cell-therapy for bronchiolitis obliterans syndrome (BOS). On the other hand, there publications demonstrating that might be involved in development of BOS. Despite limited knowledge regarding functional role tissue-resident lung-MSC, several clinical trials performed using MSC, particularly bone marrow (BM)-derived various lung...
Summary In cystic fibrosis (CF) prognosis concerning lung damage development is highly variable and difficult to predict. Mannan-binding lectin (MBL) deficiency has been reported be associated with poor outcome in CF disease. MBL a recognition molecule of the pathway complement system encoded by gene characterized high degree polymorphism. Some genotypes result low serum concentrations MBL. MBL-associated serine protease 2 (MASP-2) another protein belonging pathway. A mutation resulting...
Mesenchymal stem cells (MSC) have not only been implicated in the development of lung diseases, but they also proposed as a future cell-based therapy for diseases. However, cellular identity primary MSC human tissues has yet reported. This study therefore aimed to identify and characterise 'bona fide' lungs investigate if numbers correlate with bronchiolitis obliterans syndrome lung-transplanted patients.Primary were directly isolated or culture-derived from central peripheral transbronchial...
Unilateral non-reducing TMJ disk displacement has been shown to retard mandibular growth on the ipsilateral side, with facial asymmetry a sequela. We hypothesized that bilateral affliction would impair bilaterally, generating retrognathia. Non-reducing was surgically created in 10 growing New Zealand White rabbits. Ten additional rabbits served as sham-operated control group. Facial followed serial cephalograms, tantalum implants, during period corresponding childhood and adolescence man....
The aim of the present study was to explore occurrence fibrocytes in tissue and investigate whether appearance may be linked structural changes parenchyme vasculature lungs patients with obliterative bronchiolitis (OB) following lung or bone marrow transplantation. Identification parenchyme, vasculature, done by histological methods from lung-transplanted bronchiolitis, controls. transplanted had significantly higher amounts alveolar (46.5 ± 17.6%) than controls (21.7 7.6%) (p < 0.05). also...
Idiopathic pulmonary fibrosis (IPF), an insidious disease with grave prognosis, is characterized by heterogeneous densely fibrotic areas surrounded nonfibrotic normal-looking tissue, believed to reflect a temporal development. The etiology incompletely elucidated, but aberrant wound healing be involved. Embryonic signaling pathways, including Wnt signaling, are reactivated in healing, and we therefore aimed investigate hypothesized that would correspond degree of fibrosis. Material from 10...
Abstract Background Although allergic asthma is a complex area with many interacting factors involved, the ‘hygiene hypothesis’ proposes that lack of exposure to infection during childhood may polarise immune system towards allergen-reactive Th2-type responses in genetically susceptible individuals. Toll-like receptors (TLRs) play key role within innate and TLR7 agonists have previously been shown up-regulate Th1 down-regulate Th2 allergens murine models or chronic asthma. This study aimed...