A5033856746- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Geriatric Care and Nursing Homes
- Food Allergy and Anaphylaxis Research
- Contact Dermatitis and Allergies
- Inhalation and Respiratory Drug Delivery
- Migration, Aging, and Tourism Studies
- Dermatology and Skin Diseases
- Mast cells and histamine
- Olfactory and Sensory Function Studies
- Facilities and Workplace Management
- Intensive Care Unit Cognitive Disorders
- Urban Green Space and Health
- Urticaria and Related Conditions
- Innovative Approaches in Technology and Social Development
- Nasal Surgery and Airway Studies
- Family and Patient Care in Intensive Care Units
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Research in Social Sciences
- Social and Educational Sciences
- Tracheal and airway disorders
- Architecture and Computational Design
- Healthcare Decision-Making and Restraints
- Psychiatric care and mental health services
Region Västra Götaland
2025
Skåne University Hospital
2010-2021
Chalmers University of Technology
2010-2021
Thermo Fisher Scientific (United States)
2020
Getinge (Sweden)
2015
Lund University
1993-2007
Griffith University
2003
Uppsala University
2002
Woolcock Institute of Medical Research
2000-2001
Royal Prince Alfred Hospital
2000-2001
To determine predictors for failed reduction of inhaled corticosteroids (ICS), in 50 subjects with well-controlled asthma (age 43.7 [18–69]; 22 males) taking a median dose 1,000 μ g ICS/d (100–3,600 g/d), ICS were halved every 8 wk. Airway hyperresponsiveness (AHR) to bronchial provocation test (BPT) histamine was measured at baseline. AHR BPT mannitol, spirometry, exhaled nitric oxide (eNO), and, 31 subjects, sputum inflammatory cells baseline and monthly intervals. Thirty-nine suffered an...
Allergic rhinitis is a global illness with well-recognised impact on quality of life and work performance. Comparatively little known about the extent its economic society. The TOTALL study estimates total cost allergic using sample representing entire Swedish population working age. A questionnaire focused was mailed out to random residents, aged 18–65 years. Health-care contacts, medications, absenteeism (absence from work) presenteeism (reduced capacity at were assessed, direct indirect...
BackgroundThe SQ tree sublingual immunotherapy (SLIT)–tablet (ALK-Abelló, Hørsholm, Denmark) is developed for treatment of pollen–induced allergic rhinoconjunctivitis (ARC).ObjectiveThe aim this pivotal phase III trial was to demonstrate the efficacy and safety SLIT-tablet.MethodsThis a randomized, double-blind, placebo-controlled with 634 subjects (12-65 years) moderate-to-severe ARC despite use symptom-relieving medication. Eligible were randomized 1:1 active or placebo treatment. The...
Cytotoxic eosinophil granule proteins are considered important in the pathogenesis of allergic airway diseases such as rhinitis and asthma. To explore cellular mechanisms behind release human airways, 16 symptom-free patients with seasonal were challenged daily allergen during 1 wk. Nasal lavage samples biopsies, obtained before 24 h after last exposure, processed for immunohistochemical electron microscopic analysis. The challenges produced nasal symptoms, marked tissue eosinophilia, an...
To provide evidence-based guidance on practical aspects and potential safety concerns (infusion reactions hypophosphataemia) related to the use of intravenous iron from a nursing perspective. A modified Delphi consensus method. Literature searches were conducted used support development 16 statements. Six nurses with expertise in field gastroenterology experience administration participated process develop final set Overall, statements achieved covered practicalities administration, infusion...
Specific immunotherapy (SIT) is the only treatment with proved long-term curative potential in patients allergic disease. Allergen-specific IgE causative agent of disease, and antibodies contribute to SIT, but effects SIT on aeroallergen-specific B-cell repertoires are not well understood.We sought characterize sequences expressed by allergen-specific B cells track fate these clones during SIT.We used high-throughput antibody gene sequencing identification combinatorial fragment library...
In steroid-naïve asthmatics, airway hyperresponsiveness correlates with noninvasive markers of inflammation. Whether this is also true in steroid-treated unknown. 31 stable asthmatics (mean age 45.4 yrs, range 22–69; 17 females) taking a median dose 1,000 µg inhaled corticosteroids (ICS) per day (range 100–3,600 µg·day −1 ), responsiveness to the “direct” agent histamine and “indirect” mannitol, lung function (forced expiratory volume one second (FEV 1 forced vital capacity (FVC), peak flow...
Summary This study examined the seasonal effects on eosinophils and secretory responsiveness of nasal mucosa in 22 patients with allergic rhinitis due to birch pollen (11 received placebo 11 budesonide. 200 μg once daily each nostril). The counts during season were too low produce a significant symptomatology. Hence, our findings demonstrate threshold alterations airway their inhibition by anti‐inflammatory drug intervention. monitored for 8 weeks recordings symptom scores. Once every week...
It has previously been demonstrated that topical nasal treatment with glucocorticosteroids significant effects on the bronchial airways. Less is known about disease by these drugs. The present study examined allergic of inhaled budesonide (avoiding deposition drug). Patients seasonal rhinitis, but without asthma, were thus given inhalations (600 microg b.i.d.) or placebo. aim design was to allow eosinophilic airway in a part other than directly treated locus. Moderate high birch pollen...
Summary Background Mucosal exudation of plasma is a non‐injurious, physiological response the airway microcirculation to different inflammatory processes. The exudative similar in nose and bronchi occurs both allergic asthma rhinitis. educative specific end‐organ function mucosal that may be altered diseases. Objective This study examines hypothesis responsiveness superficial vascular permeability‐increasing challenges sustained inflammation. Methods Fourteen patients with birch‐pollen...
A few studies have examined the incidence and remission of allergic rhinitis (AR) in same general population.A questionnaire focused on respiratory symptoms airway diseases was mailed out 1992 2000 to subjects. Of 4933 subjects, aged 20-59 years, 4280 (86.8%) answered at both occasions. AR defined self-reported a simultaneous report nasal provoked by exposure either tree-, grass-pollen, furred animals or house dust. Multiple logistic regression adjusted for age gender used analyze potential...
In allergic diseases, eosinophils in affected tissues release granule proteins with cytotoxic, immunoregulatory, and remodelling-promoting properties. From recent observations, it may be assumed that degranulate already circulating blood. If degranulation occurs the circulation, this could contribute to widespread systemic effects provide an important marker of disease.To determine status common diseases.Using a novel approach whole blood fixation leucocyte preparation, morphology from...
BACKGROUND--Mucosal exudation (luminal entry) of bulk plasma is a key feature airway defence and inflammation. In guinea pig rat airways this response readily produced by neurogenic irritants, notably capsaicin. Thus "neurogenic inflammation" has become an established concept. The present study examines whether capsaicin also produces mucosal in human nasal both health disease (seasonal allergic rhinitis). METHODS--Pain-producing concentrations (30-300 ng/ml) were applied to the surface...
It has been previously demonstrated in nasal challenge studies that there is an increased sensitivity to allergen following initial challenge. A similar feature natural exposure patients with seasonal allergic rhinitis. To further explore the characteristics of this “priming” phenomenon and its relationship other expressions their airway disease, 28 hay fever strictly disease were studied. Skin tests relevant pollen histamine performed size immediate late phase reaction was determined. An...