A5003340200- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Respiratory Support and Mechanisms
- Pediatric health and respiratory diseases
- Cardiovascular and exercise physiology
- Neonatal Respiratory Health Research
- Allergic Rhinitis and Sensitization
- Pulmonary Hypertension Research and Treatments
- Air Quality and Health Impacts
- Heart Rate Variability and Autonomic Control
- Noise Effects and Management
- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Cystic Fibrosis Research Advances
- Air Quality Monitoring and Forecasting
- Bioinformatics and Genomic Networks
- Dermatology and Skin Diseases
- Inhalation and Respiratory Drug Delivery
- Fibroblast Growth Factor Research
- Safety Warnings and Signage
- Contact Dermatitis and Allergies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Vehicle emissions and performance
- Pneumonia and Respiratory Infections
Lund University
2013-2025
Skåne University Hospital
2014-2021
NIHR Southampton Biomedical Research Centre
2019
University of Southampton
2019
AstraZeneca (Sweden)
2004-2015
State Key Laboratory of Respiratory Disease
2015
Guangzhou Medical University
2015
Arete (United Kingdom)
2014
AstraZeneca (United Kingdom)
2014
Respiratory Clinical Trials
2003-2011
There is growing evidence that air pollution from traffic has adverse long-term effects on chronic respiratory disease in children, but there are few studies and more inconclusive results adults. We examined associations between residential asthma COPD adults southern Sweden. A postal questionnaire 2000 (n = 9319, 18–77 years) provided status, self-reported exposure to traffic. Geographical Information System (GIS) was used link geocoded addresses a Swedish road database an emission for NOx....
There is conflicting evidence that traffic-related air pollution a risk factor for allergic conditions. Few studies have investigated this in adults. In adults, high proportion of asthma, rhinitis and eczema triggered by non-allergic factors. We traffic as versus asthma rhinitis, eczema, A questionnaire from 2000 (n = 9319, 18-77 years) provided individual data about disease outcome self-reported exposure. Additional exposure assessments were obtained using Geographical Informations Systems...
Purpose: Chronic rhinosinusitis (CRS) is related to asthma and chronic obstructive pulmonary disease (COPD). However, combined data on CRS, function, lower airway symptoms, cigarette smoking from the general population are lacking. The current study investigates relationships between CRS airflow limitation (CAL), symptoms COPD in a middle-aged of ever-smokers never-smokers. Patients Methods: All subjects Swedish CArdioPulmonary bioImage Study (SCAPIS) were included. Subjects underwent...
The aim of the present study was to evaluate relationship between matrix degradation biomarkers, desmosine and isodesmosine (desmosines), lung function. Plasma creatinine-corrected urinary total desmosines (P- U-desmosines, respectively), function diffusing capacity for carbon monoxide ( D L,CO ) were measured in a cohort subjects from Swedish Twin Registry. Concentrations U- P-desmosines 349 318 subjects, respectively; approximately one-third had chronic obstructive pulmonary disease...
Using a postal questionnaire the prevalence of hand eczema was determined in general population 11,798 individuals aged 20-77 years who were randomly drawn from records. The response rate 78.1%. One-year among women varied between 1.9% and 10.8%, with highest figure those 30-39 years. corresponding figures for men 2.3% 5.6%, 20-29 Lifetime 5.7% 16.7% 5.2% 9.5% men. multiple logistic regression analysis female sex (OR=1.91, 95% CI 1.47-2.47) smoking (OR=1.35, 1.04-1.75) independent risk...
A few studies have examined the incidence and remission of allergic rhinitis (AR) in same general population.A questionnaire focused on respiratory symptoms airway diseases was mailed out 1992 2000 to subjects. Of 4933 subjects, aged 20-59 years, 4280 (86.8%) answered at both occasions. AR defined self-reported a simultaneous report nasal provoked by exposure either tree-, grass-pollen, furred animals or house dust. Multiple logistic regression adjusted for age gender used analyze potential...
Potential links between eczema and obstructive pulmonary diseases have been postulated. Previously we reported the prevalence of upper lower respiratory relation to environmental socio-economic factors in a randomly selected adult population southern Sweden using postal questionnaire. In present study wanted analyse its status, heredity an population.Self-reported eczema, symptoms, asthma Chronic Bronchitis Emphysema (CBE) were examined 12,071 adults, aged 20-59 years, living by There...
Rationale: Smoking is a primary risk factor for chronic bronchitis, emphysema, and obstructive pulmonary disease, but since not all smokers develop it has been suggested that some individuals may be more susceptible to exogenous factors, such as smoking, this susceptibility could genetically determined.Objectives: The aim of the present study was assess, in population-based sample twins, following: (1) what extent genetic factors contribute development including taking sex into...
Background Matrix metalloproteinases (MMP´s) are known biomarkers of atherosclerosis. MMP´s also involved in the pathophysiological processes underlying chronic obstructive pulmonary disease (COPD). Cigarette smoking plays an important role both states and is to affect concentration activity systemically. Unfortunately, epidemiological data concerning value as COPD atherosclerosis with special regards habits limited. Methods 450 middle-aged subjects records tobacco consumption were examined...
The understanding of the influence smoking and sex on lung function symptoms is important for diseases such as COPD. both genes environment function, behaviour presence respiratory has previously been demonstrated each these separately. Hence, can by co-varying not only an environmental factor, but also shared genetic pathways. Therefore, objective was to evaluate heritability different aspects investigate how estimates are affected adjustments symptoms. current study based a selected sample...
Background: The BREATHE study is a cross-sectional of real-life patients with asthma and/or COPD in Denmark and Sweden aiming to increase the knowledge across severities combinations obstructive airway disease.Design: Patients suspicion healthy controls were invited participate had standard evaluation performed consisting questionnaires, physical examination, FeNO lung function, mannitol provocation test, allergy collection sputum blood samples. A subgroup bronchoscopy samples.Results:...
In a 1992 questionnaire study, we found that certain nasal symptoms and symptom-provoking factors were associated with prevalence of self-reported chronic bronchitis/emphysema (CBE). this follow-up examined whether any features could predict an increased incidence physician's diagnosis CBE/chronic obstructive pulmonary disease (COPD). 2000, survey was performed similar to the one in 1992. Of paired group 4933 participants aged 28-67 years, 4280 (86.8%) returned questionnaire. Odds ratios...
Previous studies on associations between reduced lung function and cardiovascular disease (CVD) have mainly been based forced expiratory volume in 1-s (FEV(1) ) vital capacity (VC). This study examined potential five different variables plaques the internal carotid artery (ICA).Subjects (n = 450) from a previous population-based respiratory questionnaire survey [current smokers without lower symptoms, subjects with self-reported diagnosis of chronic obstructive pulmonary (COPD) never-smokers...
There is no general agreement on the spirometric definition of chronic obstructive pulmonary disease (COPD). The global initiative for lung recommends a fixed ratio between forced expiratory volume in one-second (FEV1 ) and vital capacity (FVC) <0·7 (FR) diagnosis COPD. European Respiratory Society American Thoracic favour use fifth percentile age-related FEV1 /FVC (the lower limit normal, LLN). purpose this study was to analyse extensive function tests groups subjects fulfilling none,...